HPV, protein p16 and squamous cell carcinoma of the oral cavity

BLAHÁK, Jiří, Jiří ZELINKA, Jaromír GUMULEC, Ctirad MACHÁČEK, Zdeněk DANĚK and Oliver BULIK. HPV, protein p16 and squamous cell carcinoma of the oral cavity. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2020, vol. 164, No 3, p. 292-299. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2019.026.

Basic information

• Original name: HPV, protein p16 and squamous cell carcinoma of the oral cavity
• Authors: BLAHÁK, Jiří (203 Czech Republic, guarantor, belonging to the institution), Jiří ZELINKA (203 Czech Republic, belonging to the institution), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Ctirad MACHÁČEK (203 Czech Republic, belonging to the institution), Zdeněk DANĚK (203 Czech Republic, belonging to the institution) and Oliver BULIK (203 Czech Republic, belonging to the institution).
• Edition: Biomedical Papers, Olomouc, Univerzita Palackého v Olomouci, 2020, 1213-8118.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30109 Pathology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.245
• RIV identification code: RIV/00216224:14110/20:00116360
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.5507/bp.2019.026
• UT WoS: 000595645600011
• Keywords in English: oral squamous cell carcinoma; oral cancer; HPV; human papilloma virus; p16
• Tags: 14110227, 14110230, 14110518, rivok
• Tags: International impact, Reviewed

Abstract

Background: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. Methods: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. Results: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). Conclusions: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.