Cerebrocerebellar structural covariance in temporal lobe
epilepsy with hippocampal sclerosis

J 2020

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

MARCIÁN, Václav, Radek MAREČEK, Martin PAIL a Milan BRÁZDIL

Základní údaje

Originální název

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Autoři

MARCIÁN, Václav (703 Slovensko, garant, domácí), Radek MAREČEK (203 Česká republika, domácí), Martin PAIL (203 Česká republika, domácí) a Milan BRÁZDIL (203 Česká republika, domácí)

Vydání

Epilepsy & Behavior, San Diego, Elsevier, 2020, 1525-5050

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.937

Kód RIV

RIV/00216224:14110/20:00116365

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.yebeh.2020.107180

UT WoS

000577327900017

Klíčová slova anglicky

Temporal lobe epilepsy; Hippocampal sclerosis; Cerebellum; Structural covariance; Amygdala enlargement; Voxel-based morphometry

Štítky

14110127, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 10. 2020 07:15, Mgr. Tereza Miškechová

Anotace

V originále

Purpose The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum. Methods The study cohort included 21 patients with intractable TLE-HS (14 left-sided, 7 right-sided) and 38 healthy controls (HC). All patients later underwent anteromedial temporal lobe resection. All subjects were examined using a 1.5-T magnetic resonance imaging (MRI). Volumes of distinct cerebral and cerebellar structures were measured using voxel-based morphometry. The structural covariance of temporal lobe structures, insula, and thalamus with cerebellar substructures was examined using partial least squares regression. Results Morphological changes were more significant in the group with left TLE-HS when comparing left-sided with right-sided structures as well as when comparing patients with controls. The gray matter volume (GMV) of the temporal lobe structures was smaller ipsilaterally to the seizure onset side in most cases. There was a significant amygdala enlargement contralateral to the side of hippocampal sclerosis in both patients with right and left TLE-HS as compared with controls. Selected vermian structures in patients with left but not right TLE-HS had significantly larger GMV than the identical substructures in controls. The structural covariance differed significantly between patients with left and right TLE-HS as compared with HC. The analysis revealed significant negative covariance between anterior vermis and mesial temporal structures in the group with left TLE-HS. No significance was observed for the group with right TLE-HS. Conclusion There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLE-HS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

MARCIÁN, Václav, Radek MAREČEK, Martin PAIL a Milan BRÁZDIL. Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis. Epilepsy & Behavior. San Diego: Elsevier, 2020, roč. 111, OCT 2020, s. 1-8. ISSN 1525-5050. Dostupné z: https://dx.doi.org/10.1016/j.yebeh.2020.107180.

@article{1677830,
   author = {Marcián, Václav and Mareček, Radek and Pail, Martin and Brázdil, Milan},
   article_location = {San Diego},
   article_number = {OCT 2020},
   doi = {http://dx.doi.org/10.1016/j.yebeh.2020.107180},
   keywords = {Temporal lobe epilepsy; Hippocampal sclerosis; Cerebellum; Structural covariance; Amygdala enlargement; Voxel-based morphometry},
   language = {eng},
   issn = {1525-5050},
   journal = {Epilepsy & Behavior},
   title = {Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis},
   url = {https://www.sciencedirect.com/science/article/pii/S1525505020303590},
   volume = {111},
   year = {2020}
}

TY  - JOUR
ID  - 1677830
AU  - Marcián, Václav - Mareček, Radek - Pail, Martin - Brázdil, Milan
PY  - 2020
TI  - Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis
JF  - Epilepsy & Behavior
VL  - 111
IS  - OCT 2020
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 15255050
KW  - Temporal lobe epilepsy
KW  - Hippocampal sclerosis
KW  - Cerebellum
KW  - Structural covariance
KW  - Amygdala enlargement
KW  - Voxel-based morphometry
UR  - https://www.sciencedirect.com/science/article/pii/S1525505020303590
L2  - https://www.sciencedirect.com/science/article/pii/S1525505020303590
N2  - Purpose The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum. Methods The study cohort included 21 patients with intractable TLE-HS (14 left-sided, 7 right-sided) and 38 healthy controls (HC). All patients later underwent anteromedial temporal lobe resection. All subjects were examined using a 1.5-T magnetic resonance imaging (MRI). Volumes of distinct cerebral and cerebellar structures were measured using voxel-based morphometry. The structural covariance of temporal lobe structures, insula, and thalamus with cerebellar substructures was examined using partial least squares regression. Results Morphological changes were more significant in the group with left TLE-HS when comparing left-sided with right-sided structures as well as when comparing patients with controls. The gray matter volume (GMV) of the temporal lobe structures was smaller ipsilaterally to the seizure onset side in most cases. There was a significant amygdala enlargement contralateral to the side of hippocampal sclerosis in both patients with right and left TLE-HS as compared with controls. Selected vermian structures in patients with left but not right TLE-HS had significantly larger GMV than the identical substructures in controls. The structural covariance differed significantly between patients with left and right TLE-HS as compared with HC. The analysis revealed significant negative covariance between anterior vermis and mesial temporal structures in the group with left TLE-HS. No significance was observed for the group with right TLE-HS. Conclusion There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLE-HS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus.
ER  -

MARCIÁN, Václav, Radek MAREČEK, Martin PAIL a Milan BRÁZDIL. Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis. \textit{Epilepsy \&{} Behavior}. San Diego: Elsevier, 2020, roč.~111, OCT 2020, s.~1-8. ISSN~1525-5050. Dostupné z: https://dx.doi.org/10.1016/j.yebeh.2020.107180.

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