Detailed Information on Publication Record
2020
The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study
MARCINIAK, Rafał, Rastislav ŠUMEC, Martin VYHNÁLEK, Kamila BENDÍČKOVÁ, Petra LÁZNIČKOVÁ et. al.Basic information
Original name
The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study
Authors
MARCINIAK, Rafał (203 Czech Republic, belonging to the institution), Rastislav ŠUMEC (703 Slovakia, belonging to the institution), Martin VYHNÁLEK (203 Czech Republic), Kamila BENDÍČKOVÁ (203 Czech Republic), Petra LÁZNIČKOVÁ (203 Czech Republic, belonging to the institution), Giancarlo FORTE (380 Italy), Andrej JELENÍK (203 Czech Republic), Veronika ŘÍMALOVÁ (203 Czech Republic), Jan FRIČ (203 Czech Republic), Jakub HORT (203 Czech Republic) and Kateřina SHEARDOVÁ (203 Czech Republic, guarantor)
Edition
Clinical Interventions in Aging, Auckland, DOVE MEDICAL PRESS, 2020, 1176-9092
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30227 Geriatrics and gerontology
Country of publisher
New Zealand
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.824 in 2013
RIV identification code
RIV/00216224:14110/20:00116380
Organization unit
Faculty of Medicine
UT WoS
000575553400001
Keywords in English
cognition; depression; anxiety; MCI; neurodegeneration; monocyte activation
Tags
International impact, Reviewed
Změněno: 12/5/2021 13:47, Mgr. Tereza Miškechová
Abstract
V originále
Background: Mindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion from mild cognitive impairment (MCI) to dementia such as depression, stress, cognitive decline, immune system and brain structural and functional changes. Studies on mindfulness in MCI subjects are sparse and frequently lack control intervention groups. Objective: To determine the feasibility and the effect of mindfulness-based stress reduction (MBSR) practice on depression, cognition and immunity in MCI compared to cognitive training. Methods: Twenty-eight MCI subjects were randomly assigned to two groups. MBSR group underwent 8-week MBSR program. Control group underwent 8-week cognitive training. Their cognitive and immunological profiles and level of depressive symptoms were examined at baseline, after each 8-week intervention (visit 2, V2) and six months after each intervention (visit 3, V3). MBSR participants completed feasibility questionnaire at V2. Results: Twenty MCI patients completed the study (MBSR group n=12, control group n=8). MBSR group showed significant reduction in depressive symptoms at both V2 (p=0.03) and V3 (p=0.0461) compared to the baseline. There was a minimal effect on cognition - a group comparison analysis showed better psychomotor speed in the MBSR group compared to the control group at V2 (p=0.0493) but not at V3. There was a detectable change in immunological profiles in both groups, more pronounced in the MBSR group. Participants checked only positive/neutral answers concerning the attractivity/length of MBSR intervention. More severe cognitive decline (PVLT=36) was associated with the lower adherence to home practice. Conclusion: MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile. Keywords
Links
| MUNI/A/1204/2017, interní kód MU |
|