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@article{1678820,
author = {DíazandGarcía, Diana and Sommerová, Lucia and Martišová, Andrea and Skoupilová, Hana and Prashar, Sanjiv and Vaculovič, Tomáš and Kanický, Viktor and del Hierro, Isabel and Hrstka, Roman and GómezandRuiz, Santiago},
article_location = {Amsterdam},
article_number = {JUN 15 2020},
doi = {http://dx.doi.org/10.1016/j.micromeso.2020.110154},
keywords = {Organotin(IV); Anticancer; Mesoporous silica nanoparticles; Cytotoxicity; Folic acid; Cell migration; Cell invasion},
language = {eng},
issn = {1387-1811},
journal = {Microporous and Mesoporous Materials},
title = {Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells.},
url = {https://doi.org/10.1016/j.micromeso.2020.110154},
volume = {300},
year = {2020}
}
TY - JOUR
ID - 1678820
AU - Díaz-García, Diana - Sommerová, Lucia - Martišová, Andrea - Skoupilová, Hana - Prashar, Sanjiv - Vaculovič, Tomáš - Kanický, Viktor - del Hierro, Isabel - Hrstka, Roman - Gómez-Ruiz, Santiago
PY - 2020
TI - Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells.
JF - Microporous and Mesoporous Materials
VL - 300
IS - JUN 15 2020
SP - 1-14
EP - 1-14
PB - Elsevier
SN - 13871811
KW - Organotin(IV)
KW - Anticancer
KW - Mesoporous silica nanoparticles
KW - Cytotoxicity
KW - Folic acid
KW - Cell migration
KW - Cell invasion
UR - https://doi.org/10.1016/j.micromeso.2020.110154
L2 - https://doi.org/10.1016/j.micromeso.2020.110154
N2 - Mesoporous silica nanoparticles (MSN) have been functionalized with the polyamino ligand N-1-(3-trimethoxysilylpropyediethylenetriamine to give the material MSN-DETATMS (M1). The reaction of M1 with the diphenyltin(IV) compound Sn1 [obtained previously from the reaction of (3-glycidyloxypropyl)trimethoxysilane and diphenyltin(IV) dichloride in the presence of two equivalents of sodium hydroxide] in a quantity to obtain a theoretical 10% wt Sn/SiO2, gave the material MSN-DETATMS-O-2-SnPh2 (M2). Alternatively, M1 was reacted with folic acid to achieve the incorporation of the folate fragment via formation of an amido bond MSN-DETATMS-FA (M3) and subsequently with Snl to give the tin-functionalized material MSN-DETATMS-FA-O-2-SnPh2 (M4). M1-M4 have been characterized by several methods such as infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), X-ray fluorescence (XRF), solid-state NMR spectroscopy, nitrogen adsorption-desorption isotherms, electrochemical methods, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). All the synthesized nanomaterials have been tested in vitro against a wide variety of cancer and noncancer cells in order to determine different aspects of their antitumour effects such as cell uptake, cell death, cell migration and cell invasion, to observe whether the incorporation of folate fragments may increase the cell uptake and selectivity towards cancer cells, thus increasing their potential applicability in future chemotherapeutic approaches.
ER -
DÍAZ-GARCÍA, Diana, Lucia SOMMEROVÁ, Andrea MARTIŠOVÁ, Hana SKOUPILOVÁ, Sanjiv PRASHAR, Tomáš VACULOVIČ, Viktor KANICKÝ, Isabel DEL HIERRO, Roman HRSTKA a Santiago GÓMEZ-RUIZ. Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells. \textit{Microporous and Mesoporous Materials}. Amsterdam: Elsevier, 2020, roč.~300, JUN 15 2020, s.~1-14. ISSN~1387-1811. Dostupné z: https://dx.doi.org/10.1016/j.micromeso.2020.110154.
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