Adipophilin and perilipin 3 positively correlate with total
lipid content in human breast milk

J 2020

Adipophilin and perilipin 3 positively correlate with total lipid content in human breast milk

PAVLOVÁ, Tereza, Zdeněk SPÁČIL, Veronika VIDOVÁ, Filip ZLÁMAL, Eliška ČECHOVÁ et. al.

Základní údaje

Originální název

Adipophilin and perilipin 3 positively correlate with total lipid content in human breast milk

Autoři

PAVLOVÁ, Tereza (203 Česká republika, domácí), Zdeněk SPÁČIL (203 Česká republika, domácí), Veronika VIDOVÁ (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Eliška ČECHOVÁ (203 Česká republika, domácí), Zuzana HODICKÁ (203 Česká republika) a Julie DOBROVOLNÁ (203 Česká republika, garant, domácí)

Vydání

Scientific reports, London, Nature Publishing Group, 2020, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10700 1.7 Other natural sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.379

Kód RIV

RIV/00216224:14310/20:00114318

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/s41598-019-57241-w

UT WoS

000551443900011

Klíčová slova anglicky

Lipids; Membrane proteins; Peptides

Štítky

14110518, GPK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 11. 2020 13:58, Mgr. Marie Šípková, DiS.

Anotace

V originále

Lipids are secreted into milk as bilayer-coated structures: milk fat globules (MFGs). Adipophilin (ADRP) and perilipin 3 (TIP47) are associated with MFGs in human breast milk; however, the role of these proteins in milk lipid secretion is not fully understood. The study aimed to investigate levels of ADRP, TIP47 and total lipid content in human breast milk, their mutual correlations, and dynamics during lactation. Milk samples from 22 healthy lactating women (Caucasian, Central European) were collected at five time points during lactation (1-3, 12-14, 29-30, 88-90 and 178-180 days postpartum). Mass spectrometry-based method was used for quantification of ADRP and TIP47 in the samples. The gravimetric method was used to determine milk total lipid content. We observed distinctive trends in ADRP, TIP47 levels and lipid content in human breast milk during the first six months of lactation. We also found a significant association between lipid content and ADRP, lipid content and TIP47, and ADRP and TIP47 concentrations in breast milk at all sampling points. A mass spectrometry-based method was developed for quantifying ADRP and TIP47 in human breast milk. Strong mutual correlations were found between ADRP, TIP47 and total lipid content in human breast milk.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

GJ17-24592Y, projekt VaV

Název: Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

Investor: Grantová agentura ČR, Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

PAVLOVÁ, Tereza, Zdeněk SPÁČIL, Veronika VIDOVÁ, Filip ZLÁMAL, Eliška ČECHOVÁ, Zuzana HODICKÁ a Julie DOBROVOLNÁ. Adipophilin and perilipin 3 positively correlate with total lipid content in human breast milk. Scientific reports. London: Nature Publishing Group, 2020, roč. 10, č. 1, s. 1-9. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-57241-w.

@article{1679604,
   author = {Pavlová, Tereza and Spáčil, Zdeněk and Vidová, Veronika and Zlámal, Filip and Čechová, Eliška and Hodická, Zuzana and Dobrovolná, Julie},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-019-57241-w},
   keywords = {Lipids; Membrane proteins; Peptides},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Adipophilin and perilipin 3 positively correlate with total lipid content in human breast milk},
   url = {https://www.nature.com/articles/s41598-019-57241-w},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1679604
AU  - Pavlová, Tereza - Spáčil, Zdeněk - Vidová, Veronika - Zlámal, Filip - Čechová, Eliška - Hodická, Zuzana - Dobrovolná, Julie
PY  - 2020
TI  - Adipophilin and perilipin 3 positively correlate with total lipid content in human breast milk
JF  - Scientific reports
VL  - 10
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - Nature Publishing Group
SN  - 20452322
KW  - Lipids
KW  - Membrane proteins
KW  - Peptides
UR  - https://www.nature.com/articles/s41598-019-57241-w
L2  - https://www.nature.com/articles/s41598-019-57241-w
N2  - Lipids are secreted into milk as bilayer-coated structures: milk fat globules (MFGs). Adipophilin (ADRP) and perilipin 3 (TIP47) are associated with MFGs in human breast milk; however, the role of these proteins in milk lipid secretion is not fully understood. The study aimed to investigate levels of ADRP, TIP47 and total lipid content in human breast milk, their mutual correlations, and dynamics during lactation. Milk samples from 22 healthy lactating women (Caucasian, Central European) were collected at five time points during lactation (1-3, 12-14, 29-30, 88-90 and 178-180 days postpartum). Mass spectrometry-based method was used for quantification of ADRP and TIP47 in the samples. The gravimetric method was used to determine milk total lipid content. We observed distinctive trends in ADRP, TIP47 levels and lipid content in human breast milk during the first six months of lactation. We also found a significant association between lipid content and ADRP, lipid content and TIP47, and ADRP and TIP47 concentrations in breast milk at all sampling points. A mass spectrometry-based method was developed for quantifying ADRP and TIP47 in human breast milk. Strong mutual correlations were found between ADRP, TIP47 and total lipid content in human breast milk.
ER  -

PAVLOVÁ, Tereza, Zdeněk SPÁČIL, Veronika VIDOVÁ, Filip ZLÁMAL, Eliška ČECHOVÁ, Zuzana HODICKÁ a Julie DOBROVOLNÁ. Adipophilin and perilipin 3 positively correlate with total lipid content in human breast milk. \textit{Scientific reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-9. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-57241-w.

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