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@article{1680257, author = {Adani, Giorgia and Filippini, Tommaso and Wise, Lauren A. and Halldorsson, Thorhallur I. and Bláha, Luděk and Vinceti, Marco}, article_location = {Philadelphia}, article_number = {6}, doi = {http://dx.doi.org/10.1158/1055-9965.EPI-19-1628}, keywords = {NONSMOKING POSTMENOPAUSAL WOMEN; HEMOGLOBIN ADDUCT LEVELS; PROSPECTIVE COHORT; DRINKING-WATER; B6C3F(1) MICE; AIR-POLLUTION; F344/N RATS; GLYCIDAMIDE; EXPOSURE; CARCINOGENICITY}, language = {eng}, issn = {1055-9965}, journal = {Cancer Epidemiology, Biomarkers & Prevention}, title = {Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis}, url = {https://cebp.aacrjournals.org/content/29/6/1095}, volume = {29}, year = {2020} }
TY - JOUR ID - 1680257 AU - Adani, Giorgia - Filippini, Tommaso - Wise, Lauren A. - Halldorsson, Thorhallur I. - Bláha, Luděk - Vinceti, Marco PY - 2020 TI - Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis JF - Cancer Epidemiology, Biomarkers & Prevention VL - 29 IS - 6 SP - 1095-1106 EP - 1095-1106 PB - American Association for Cancer Research SN - 10559965 KW - NONSMOKING POSTMENOPAUSAL WOMEN KW - HEMOGLOBIN ADDUCT LEVELS KW - PROSPECTIVE COHORT KW - DRINKING-WATER KW - B6C3F(1) MICE KW - AIR-POLLUTION KW - F344/N RATS KW - GLYCIDAMIDE KW - EXPOSURE KW - CARCINOGENICITY UR - https://cebp.aacrjournals.org/content/29/6/1095 L2 - https://cebp.aacrjournals.org/content/29/6/1095 N2 - Acrylamide is a probable human carcinogen. Aside from occupational exposures and smoking, diet is the main source of exposure in humans. We performed a systematic review of the association between estimated dietary intake of acrylamide and risk of female breast, endometrial, and ovarian cancers in nonexperimental studies published through February 25, 2020, and conducted a dose-response meta-analysis. We identified 18 papers covering 10 different study populations: 16 cohort and two case-control studies. Acrylamide intake was associated with a slightly increased risk of ovarian cancer, particularly among never smokers. For endometrial cancer, risk was highest at intermediate levels of exposure, whereas the association was more linear and positive among never smokers. For breast cancer, we found evidence of a null or inverse relation between exposure and risk, particularly among never smokers and postmenopausal women. In a subgroup analysis limited to premenopausal women, breast cancer risk increased linearly with acrylamide intake starting at 20 mg/day of intake. High acrylamide intake was associated with increased risks of ovarian and endometrial cancers in a relatively linear manner, especially among never smokers. Conversely, little association was observed between acrylamide intake and breast cancer risk, with the exception of premenopausal women. ER -
ADANI, Giorgia, Tommaso FILIPPINI, Lauren A. WISE, Thorhallur I. HALLDORSSON, Luděk BLÁHA a Marco VINCETI. Dietary Intake of Acrylamide and Risk of Breast, Endometrial, and Ovarian Cancers: A Systematic Review and Dose-Response Meta-analysis. \textit{Cancer Epidemiology, Biomarkers \&{} Prevention}. Philadelphia: American Association for Cancer Research, 2020, roč.~29, č.~6, s.~1095-1106. ISSN~1055-9965. Dostupné z: https://dx.doi.org/10.1158/1055-9965.EPI-19-1628.
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