| JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA, Eva CHMELÍKOVÁ, Elena KISTANOVA a Pavel VENTRUBA. Can oocytes repair fragmented DNA of spermatozoa? Medical Journal of Cell Biology. Walter de Gruyter, 2020, roč. 8, č. 2, s. 73-77. ISSN 2544-3577. Dostupné z: https://dx.doi.org/10.2478/acb-2020-0008. |
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@article{1681577,
author = {Ješeta, Michal and Myšková, Markéta and Žáková, Jana and Crha, Igor and Crha, Karel and Chmelíková, Eva and Kistanova, Elena and Ventruba, Pavel},
article_number = {2},
doi = {http://dx.doi.org/10.2478/acb-2020-0008},
keywords = {spermatozoa; DNA integrity; apoptosis; sperm preparation},
language = {eng},
issn = {2544-3577},
journal = {Medical Journal of Cell Biology},
title = {Can oocytes repair fragmented DNA of spermatozoa?},
url = {https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml},
volume = {8},
year = {2020}
}
TY - JOUR
ID - 1681577
AU - Ješeta, Michal - Myšková, Markéta - Žáková, Jana - Crha, Igor - Crha, Karel - Chmelíková, Eva - Kistanova, Elena - Ventruba, Pavel
PY - 2020
TI - Can oocytes repair fragmented DNA of spermatozoa?
JF - Medical Journal of Cell Biology
VL - 8
IS - 2
SP - 73-77
EP - 73-77
PB - Walter de Gruyter
SN - 25443577
KW - spermatozoa
KW - DNA integrity
KW - apoptosis
KW - sperm preparation
UR - https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml
L2 - https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml
N2 - Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes. © 2020 WDG. All rights reserved.
ER -
JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA, Eva CHMELÍKOVÁ, Elena KISTANOVA a Pavel VENTRUBA. Can oocytes repair fragmented DNA of spermatozoa? \textit{Medical Journal of Cell Biology}. Walter de Gruyter, 2020, roč.~8, č.~2, s.~73-77. ISSN~2544-3577. Dostupné z: https://dx.doi.org/10.2478/acb-2020-0008.
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