Can oocytes repair fragmented DNA of spermatozoa?

J 2020

Can oocytes repair fragmented DNA of spermatozoa?

JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA et. al.

Základní údaje

Originální název

Can oocytes repair fragmented DNA of spermatozoa?

Název česky

Mohou oocyty opravit fragmentovanou DNA spermií?

Autoři

JEŠETA, Michal (203 Česká republika, garant, domácí), Markéta MYŠKOVÁ (203 Česká republika, domácí), Jana ŽÁKOVÁ (203 Česká republika, domácí), Igor CRHA (203 Česká republika, domácí), Karel CRHA (203 Česká republika, domácí), Eva CHMELÍKOVÁ (203 Česká republika), Elena KISTANOVA (100 Bulharsko) a Pavel VENTRUBA (203 Česká republika, domácí)

Vydání

Medical Journal of Cell Biology, Walter de Gruyter, 2020, 2544-3577

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/20:00116518

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2478/acb-2020-0008

Klíčová slova česky

spermie; integrita DNA; apoptóza; příprava spermií

Klíčová slova anglicky

spermatozoa; DNA integrity; apoptosis; sperm preparation

Štítky

GPK, GPKgyn, GPKonko, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 11. 2020 12:36, Mgr. Tereza Miškechová

Anotace

V originále

Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes. © 2020 WDG. All rights reserved.

Citovat

JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA, Eva CHMELÍKOVÁ, Elena KISTANOVA a Pavel VENTRUBA. Can oocytes repair fragmented DNA of spermatozoa? Medical Journal of Cell Biology. Walter de Gruyter, 2020, roč. 8, č. 2, s. 73-77. ISSN 2544-3577. Dostupné z: https://dx.doi.org/10.2478/acb-2020-0008.

@article{1681577,
   author = {Ješeta, Michal and Myšková, Markéta and Žáková, Jana and Crha, Igor and Crha, Karel and Chmelíková, Eva and Kistanova, Elena and Ventruba, Pavel},
   article_number = {2},
   doi = {http://dx.doi.org/10.2478/acb-2020-0008},
   keywords = {spermatozoa; DNA integrity; apoptosis; sperm preparation},
   language = {eng},
   issn = {2544-3577},
   journal = {Medical Journal of Cell Biology},
   title = {Can oocytes repair fragmented DNA of spermatozoa?},
   url = {https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml},
   volume = {8},
   year = {2020}
}

TY  - JOUR
ID  - 1681577
AU  - Ješeta, Michal - Myšková, Markéta - Žáková, Jana - Crha, Igor - Crha, Karel - Chmelíková, Eva - Kistanova, Elena - Ventruba, Pavel
PY  - 2020
TI  - Can oocytes repair fragmented DNA of spermatozoa?
JF  - Medical Journal of Cell Biology
VL  - 8
IS  - 2
SP  - 73-77
EP  - 73-77
PB  - Walter de Gruyter
SN  - 25443577
KW  - spermatozoa
KW  - DNA integrity
KW  - apoptosis
KW  - sperm preparation
UR  - https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml
L2  - https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml
N2  - Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes. © 2020 WDG. All rights reserved.
ER  -

JEŠETA, Michal, Markéta MYŠKOVÁ, Jana ŽÁKOVÁ, Igor CRHA, Karel CRHA, Eva CHMELÍKOVÁ, Elena KISTANOVA a Pavel VENTRUBA. Can oocytes repair fragmented DNA of spermatozoa? \textit{Medical Journal of Cell Biology}. Walter de Gruyter, 2020, roč.~8, č.~2, s.~73-77. ISSN~2544-3577. Dostupné z: https://dx.doi.org/10.2478/acb-2020-0008.

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