Dental cell type atlas reveals stem and differentiated cell
types in mouse and human teeth

J 2020

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

KŘIVÁNEK, Jan, R. A. SOLDATOV, M. E. KASTRITI, T. CHONTOROTZEA, A. N. HERDINA et. al.

Základní údaje

Originální název

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Autoři

KŘIVÁNEK, Jan (203 Česká republika, domácí), R. A. SOLDATOV, M. E. KASTRITI (203 Česká republika), T. CHONTOROTZEA, A. N. HERDINA, J. PETERSEN, B. SZAROWSKA, Marie LANDOVA (203 Česká republika), Veronika KOVÁŘ MATEJOVÁ (203 Česká republika, domácí), Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, domácí), U. KUCHLER, I. V. ZDRILIC, A. VIJAYKUMAR, A. BALIC, P. MARANGONI, O. D. KLEIN, V. C. M. NEVES, V. YIANNI, P. T. SHARPE, T. HARKANY, B. D. METSCHER, M. BAJENOFF, M. MINA, K. FRIED, P. V. KHARCHENKO a I. ADAMEYKO (garant)

Vydání

Nature Communications, London, Nature Publishing Group, 2020, 2041-1723

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 14.919

Kód RIV

RIV/00216224:14110/20:00116595

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41467-020-18512-7

UT WoS

000573746700005

Klíčová slova anglicky

dental cell type; human teeth; mouse teeth

Štítky

14110130, 14110517, CF CELLIM, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 5. 2021 13:59, Mgr. Tereza Miškechová

Anotace

V originále

Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation. Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.

Návaznosti

LM2018129, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

MUNI/A/1428/2019, interní kód MU

Název: Onemocnění dutiny ústní – etiopatogeneze, diagnostika a léčba

Investor: Masarykova univerzita, Onemocnění dutiny ústní – etiopatogeneze, diagnostika a léčba, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/H/1615/2018, interní kód MU

Název: Understanding of tooth developmental trajectories as a novel approach for dental regeneration

Investor: Masarykova univerzita, Understanding of tooth developmental trajectories as a novel approach for dental regeneration, Individuální projekty hraničního výzkumu

ROZV/23/LF17/2019, interní kód MU

Název: Vývoj a vnitřní uspořádání zubu

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vývoj a vnitřní uspořádání zubu, Interní rozvojové projekty

Citovat

KŘIVÁNEK, Jan, R. A. SOLDATOV, M. E. KASTRITI, T. CHONTOROTZEA, A. N. HERDINA, J. PETERSEN, B. SZAROWSKA, Marie LANDOVA, Veronika KOVÁŘ MATEJOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, U. KUCHLER, I. V. ZDRILIC, A. VIJAYKUMAR, A. BALIC, P. MARANGONI, O. D. KLEIN, V. C. M. NEVES, V. YIANNI, P. T. SHARPE, T. HARKANY, B. D. METSCHER, M. BAJENOFF, M. MINA, K. FRIED, P. V. KHARCHENKO a I. ADAMEYKO. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nature Communications. London: Nature Publishing Group, 2020, roč. 11, č. 1, s. 1-18. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-020-18512-7.

@article{1683658,
   author = {Křivánek, Jan and Soldatov, R. A. and Kastriti, M. E. and Chontorotzea, T. and Herdina, A. N. and Petersen, J. and Szarowska, B. and Landova, Marie and Kovář Matejová, Veronika and Izakovičová Hollá, Lydie and Kuchler, U. and Zdrilic, I. V. and Vijaykumar, A. and Balic, A. and Marangoni, P. and Klein, O. D. and Neves, V. C. M. and Yianni, V. and Sharpe, P. T. and Harkany, T. and Metscher, B. D. and Bajenoff, M. and Mina, M. and Fried, K. and Kharchenko, P. V. and Adameyko, I.},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41467-020-18512-7},
   keywords = {dental cell type; human teeth; mouse teeth},
   language = {eng},
   issn = {2041-1723},
   journal = {Nature Communications},
   title = {Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth},
   url = {https://www.nature.com/articles/s41467-020-18512-7.pdf},
   volume = {11},
   year = {2020}
}

TY  - JOUR
ID  - 1683658
AU  - Křivánek, Jan - Soldatov, R. A. - Kastriti, M. E. - Chontorotzea, T. - Herdina, A. N. - Petersen, J. - Szarowska, B. - Landova, Marie - Kovář Matejová, Veronika - Izakovičová Hollá, Lydie - Kuchler, U. - Zdrilic, I. V. - Vijaykumar, A. - Balic, A. - Marangoni, P. - Klein, O. D. - Neves, V. C. M. - Yianni, V. - Sharpe, P. T. - Harkany, T. - Metscher, B. D. - Bajenoff, M. - Mina, M. - Fried, K. - Kharchenko, P. V. - Adameyko, I.
PY  - 2020
TI  - Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
JF  - Nature Communications
VL  - 11
IS  - 1
SP  - 1-18
EP  - 1-18
PB  - Nature Publishing Group
SN  - 20411723
KW  - dental cell type
KW  - human teeth
KW  - mouse teeth
UR  - https://www.nature.com/articles/s41467-020-18512-7.pdf
L2  - https://www.nature.com/articles/s41467-020-18512-7.pdf
N2  - Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation. Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.
ER  -

KŘIVÁNEK, Jan, R. A. SOLDATOV, M. E. KASTRITI, T. CHONTOROTZEA, A. N. HERDINA, J. PETERSEN, B. SZAROWSKA, Marie LANDOVA, Veronika KOVÁŘ MATEJOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, U. KUCHLER, I. V. ZDRILIC, A. VIJAYKUMAR, A. BALIC, P. MARANGONI, O. D. KLEIN, V. C. M. NEVES, V. YIANNI, P. T. SHARPE, T. HARKANY, B. D. METSCHER, M. BAJENOFF, M. MINA, K. FRIED, P. V. KHARCHENKO a I. ADAMEYKO. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. \textit{Nature Communications}. London: Nature Publishing Group, 2020, roč.~11, č.~1, s.~1-18. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-020-18512-7.

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