The first copper(II) complex with 1,10-phenanthroline and
salubrinal with interesting biochemical properties.

J 2020

The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties.

MASURI, Sebastiano, Enzo CADONI, Maria Grazia CABIDDU, Francesco ISAIA, Maria Giovanna DEMURU et. al.

Základní údaje

Originální název

The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties.

Autoři

MASURI, Sebastiano (380 Itálie), Enzo CADONI (380 Itálie), Maria Grazia CABIDDU (380 Itálie), Francesco ISAIA (380 Itálie), Maria Giovanna DEMURU (380 Itálie), Lukáš MORÁŇ (203 Česká republika, domácí), David BUČEK (203 Česká republika), Petr VAŇHARA (203 Česká republika, domácí), Josef HAVEL (203 Česká republika, domácí) a Tiziana PIVETTA (380 Itálie, garant)

Vydání

Metallomics, Cambridge, Royal Society of Chemistry, 2020, 1756-5901

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.526

Kód RIV

RIV/00216224:14110/20:00116696

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1039/d0mt00006j

UT WoS

000542894500004

Klíčová slova anglicky

Unfolded Protein Response; X Box Binding Protein 1; Activating Transcription Factor 6

Štítky

14110517, CF CELLIM, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 1. 2021 10:09, Mgr. Tereza Miškechová

Anotace

V originále

The novel copper complex [Cu(phen)(2)(salubrinal)](ClO4)(2)(C0SAL) has been synthesised and characterised. Copper(ii) is coordinated by salubrinal through the thionic group, as shown by the UV-Vis, IR, ESI-MS and tandem mass results, together with the theoretical calculations. The formed complex showed a DPPH radical scavenging ability higher than that of salubrinal alone. Studies on lipid oxidation inhibition showed that theC0SALconcentration, required to inhibit the enzyme, was lower than that of salubrinal. The inhibition of the enzyme could take placeviaallosteric modulation, as suggested by docking calculations.C0SALshowed a good cytotoxic activity on A2780 cells, 82 fold higher than that of the precursor salubrinal and 1.4 fold higher than that of [Cu(phen)(2)(H2O)](ClO4)(2). Treatment withC0SALin SKOV3 ovarian cancer cells induced expression of GRP-78 and DDIT3 regulators of ER-stress response. The cytotoxic effect ofC0SALwas reverted in the presence of TUDCA, suggesting thatC0SALinduces cell death through ER-stress. In A2780 cells treated withC0SAL gamma-H2AX was accumulated, suggesting that DNA damage was also involved.

Návaznosti

LM2018129, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

Citovat

MASURI, Sebastiano, Enzo CADONI, Maria Grazia CABIDDU, Francesco ISAIA, Maria Giovanna DEMURU, Lukáš MORÁŇ, David BUČEK, Petr VAŇHARA, Josef HAVEL a Tiziana PIVETTA. The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties. Metallomics. Cambridge: Royal Society of Chemistry, 2020, roč. 12, č. 6, s. 891-901. ISSN 1756-5901. Dostupné z: https://dx.doi.org/10.1039/d0mt00006j.

@article{1686140,
   author = {Masuri, Sebastiano and Cadoni, Enzo and Cabiddu, Maria Grazia and Isaia, Francesco and Demuru, Maria Giovanna and Moráň, Lukáš and Buček, David and Vaňhara, Petr and Havel, Josef and Pivetta, Tiziana},
   article_location = {Cambridge},
   article_number = {6},
   doi = {http://dx.doi.org/10.1039/d0mt00006j},
   keywords = {Unfolded Protein Response; X Box Binding Protein 1; Activating Transcription Factor 6},
   language = {eng},
   issn = {1756-5901},
   journal = {Metallomics},
   title = {The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties.},
   url = {https://doi.org/10.1039/D0MT00006J},
   volume = {12},
   year = {2020}
}

TY  - JOUR
ID  - 1686140
AU  - Masuri, Sebastiano - Cadoni, Enzo - Cabiddu, Maria Grazia - Isaia, Francesco - Demuru, Maria Giovanna - Moráň, Lukáš - Buček, David - Vaňhara, Petr - Havel, Josef - Pivetta, Tiziana
PY  - 2020
TI  - The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties.
JF  - Metallomics
VL  - 12
IS  - 6
SP  - 891-901
EP  - 891-901
PB  - Royal Society of Chemistry
SN  - 17565901
KW  - Unfolded Protein Response
KW  - X Box Binding Protein 1
KW  - Activating Transcription Factor 6
UR  - https://doi.org/10.1039/D0MT00006J
L2  - https://doi.org/10.1039/D0MT00006J
N2  - The novel copper complex [Cu(phen)(2)(salubrinal)](ClO4)(2)(C0SAL) has been synthesised and characterised. Copper(ii) is coordinated by salubrinal through the thionic group, as shown by the UV-Vis, IR, ESI-MS and tandem mass results, together with the theoretical calculations. The formed complex showed a DPPH radical scavenging ability higher than that of salubrinal alone. Studies on lipid oxidation inhibition showed that theC0SALconcentration, required to inhibit the enzyme, was lower than that of salubrinal. The inhibition of the enzyme could take placeviaallosteric modulation, as suggested by docking calculations.C0SALshowed a good cytotoxic activity on A2780 cells, 82 fold higher than that of the precursor salubrinal and 1.4 fold higher than that of [Cu(phen)(2)(H2O)](ClO4)(2). Treatment withC0SALin SKOV3 ovarian cancer cells induced expression of GRP-78 and DDIT3 regulators of ER-stress response. The cytotoxic effect ofC0SALwas reverted in the presence of TUDCA, suggesting thatC0SALinduces cell death through ER-stress. In A2780 cells treated withC0SAL gamma-H2AX was accumulated, suggesting that DNA damage was also involved.
ER  -

MASURI, Sebastiano, Enzo CADONI, Maria Grazia CABIDDU, Francesco ISAIA, Maria Giovanna DEMURU, Lukáš MORÁŇ, David BUČEK, Petr VAŇHARA, Josef HAVEL a Tiziana PIVETTA. The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties. \textit{Metallomics}. Cambridge: Royal Society of Chemistry, 2020, roč.~12, č.~6, s.~891-901. ISSN~1756-5901. Dostupné z: https://dx.doi.org/10.1039/d0mt00006j.

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