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@article{1688556,
author = {Smrčka, Filip and Lubal, Přemysl},
article_location = {Basel},
article_number = {18},
doi = {http://dx.doi.org/10.3390/molecules25184164},
keywords = {Ln(III) complexes; macrocyclic ligands; Ln(III) luminescence in VIS/NIR range; antenna ligand; NAD(P)H determination; enzyme probe},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection},
url = {https://www.mdpi.com/1420-3049/25/18/4164},
volume = {25},
year = {2020}
}
TY - JOUR
ID - 1688556
AU - Smrčka, Filip - Lubal, Přemysl
PY - 2020
TI - Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection
JF - Molecules
VL - 25
IS - 18
SP - 1-16
EP - 1-16
PB - MDPI
SN - 14203049
KW - Ln(III) complexes
KW - macrocyclic ligands
KW - Ln(III) luminescence in VIS/NIR range
KW - antenna ligand
KW - NAD(P)H determination
KW - enzyme probe
UR - https://www.mdpi.com/1420-3049/25/18/4164
L2 - https://www.mdpi.com/1420-3049/25/18/4164
N2 - Ln(III) complexes of macrocyclic ligands are used in medicinal chemistry, for example as contrast agents in MRI or radiopharmaceutical compounds, and in diagnostics using fluorescence imaging. This paper is devoted to a spectroscopic study of Ln(III) ternary complexes consisting of macrocyclic heptadentate DO3A and bidentate 3-isoquinolinate (IQCA) ligands. IQCA serves as an efficient antenna ligand, leading to a higher quantum yield and Stokes shift (250–350 nm for Eu, Tb, Sm, Dy in VIS region, 550–650 nm for Yb, Nd in NIR region). The shielding-quenching effect of NAD(P)H on the luminescence of the Ln(III) ternary complexes was investigated in detail and this phenomenon was utilized for the analytical determination of this compound. This general approach was verified through an enzymatic reaction during which the course of ethanol transformation catalyzed by alcohol-dehydrogenase (ADH) was followed by luminescence spectroscopy. This method can be utilized for selective and sensitive determination of ethanol concentration and/or ADH enzyme activity. This new analytical method can also be used for other enzyme systems coupled with NAD(P)H/NAD(P)+ redox pairs.
ER -
SMRČKA, Filip a Přemysl LUBAL. Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection. \textit{Molecules}. Basel: MDPI, 2020, roč.~25, č.~18, s.~1-16. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules25184164.
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