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@article{1688776, author = {Komendová, Martina and Urban, Jiří}, article_location = {Amsterdam}, article_number = {MAY 10 2020}, doi = {http://dx.doi.org/10.1016/j.chroma.2020.460893}, keywords = {Dopamine; Dual-retention; Polymer monolith; Regression analysis; Retention model}, language = {eng}, issn = {0021-9673}, journal = {Journal of Chromatography A}, title = {Dual-retention mechanism of dopamine-related compounds on monolithic stationary phase with zwitterion functionality}, url = {https://doi.org/10.1016/j.chroma.2020.460893}, volume = {1618}, year = {2020} }
TY - JOUR ID - 1688776 AU - Komendová, Martina - Urban, Jiří PY - 2020 TI - Dual-retention mechanism of dopamine-related compounds on monolithic stationary phase with zwitterion functionality JF - Journal of Chromatography A VL - 1618 IS - MAY 10 2020 SP - 1-8 EP - 1-8 PB - Elsevier SN - 00219673 KW - Dopamine KW - Dual-retention KW - Polymer monolith KW - Regression analysis KW - Retention model UR - https://doi.org/10.1016/j.chroma.2020.460893 L2 - https://doi.org/10.1016/j.chroma.2020.460893 N2 - Seven retention models have been selected to describe a dual-retention behavior of ten dopamine-related compounds on polymer-based monolithic stationary phase with zwitterion sulfobetaine functionality. Regression quality, as well as a statistical significance of individual regression parameters, have been evaluated. Better regression performance showed two four-parameter models when compared to threeparameter models. On the other hand, limited number of experimental points disqualified statistical robustness of four-parameter models. Among three-parameter models, retention description introduced by Horvath and Liang provided comparable quality of regression at significantly improved robustness. Multivariate analysis of the best three-parameter models provided the description of physicochemical properties of dopamine precursors and metabolites. Principal component analysis and logistic regression allowed structural characterization of dopamine-related compounds based solely on regression parameters extracted from an isocratic elution data. Both polarity and type of functional groups has been correctly assigned for 3-methoxytyramine that has not been part of an evaluation study. Among applied dual-retention models, Horvath ' s model, initially developed to describe a retention of ionic compounds on nonpolar stationary phases, provided robust regression of experimental data and allowed an extraction of structural characteristics of dopamine-related compounds. ER -
KOMENDOVÁ, Martina a Jiří URBAN. Dual-retention mechanism of dopamine-related compounds on monolithic stationary phase with zwitterion functionality. \textit{Journal of Chromatography A}. Amsterdam: Elsevier, 2020, roč.~1618, MAY 10 2020, s.~1-8. ISSN~0021-9673. Dostupné z: https://dx.doi.org/10.1016/j.chroma.2020.460893.
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