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@proceedings{1688880, author = {Schindler, Ondřej and Raček, Tomáš and Svobodová, Radka and Berka, Karel and Koča, Jaroslav}, booktitle = {ELIXIR CZ Annual Conference 2020}, keywords = {partial atomic charges; empirical methods; SQE; proteins}, language = {eng}, isbn = {978-80-86241-65-4}, title = {SQE charge calculation and its applicability for proteins}, year = {2020} }
TY - CONF ID - 1688880 AU - Schindler, Ondřej - Raček, Tomáš - Svobodová, Radka - Berka, Karel - Koča, Jaroslav PY - 2020 TI - SQE charge calculation and its applicability for proteins SN - 9788086241654 KW - partial atomic charges KW - empirical methods KW - SQE KW - proteins N2 - Partial atomic charges are real numbers approximating a distribution of electron density among atoms of the molecule. They find applications in computational chemistry, chemoinformatics, bioinformatics and nanoscience. Because the charges are not physico- chemical observables but rather a theoretical concept, a lot of methods for their calculation were developed. The most reliable are quantum mechanical (QM) methods, but their strong disadvantage is the high computational complexity. Faster alternatives to QM methods are empirical charge calculation methods. They calculate charges based on common physico-chemical laws, but they include empirical parameters. Currently, frequently used empirical methods are EEM, QEq, and EQEq. However, even these advanced and popular methods have their limitations – e.g., their application for peptides, proteins, and other homogeneous molecular systems is problematic. A recent and promising empirical charge calculation method is a Split-charge Equilibration method (SQE). In this work, we introduce SQE extension SQE+qp, adapted for peptides. We also present an implementation of SQE and SQE+qp via a web application Atomic Charge Calculator II. Finally, we also present a method optGM for the fast parameterization of empirical charge calculation methods. ER -
SCHINDLER, Ondřej, Tomáš RAČEK, Radka SVOBODOVÁ, Karel BERKA a Jaroslav KOČA. SQE charge calculation and its applicability for proteins. In \textit{ELIXIR CZ Annual Conference 2020}. 2020. ISBN~978-80-86241-65-4.
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