The prognostic significance of periprocedural infarction in the
era of potent antithrombotic therapy. The PRAGUE-18 substudy

J 2020

The prognostic significance of periprocedural infarction in the era of potent antithrombotic therapy. The PRAGUE-18 substudy

DUSEK, Jaroslav, Zuzana MOTOVSKA, Ota HLINOMAZ, Roman MIKLÍK, Milan HROMADKA et. al.

Základní údaje

Originální název

The prognostic significance of periprocedural infarction in the era of potent antithrombotic therapy. The PRAGUE-18 substudy

Autoři

DUSEK, Jaroslav (203 Česká republika), Zuzana MOTOVSKA (203 Česká republika, garant), Ota HLINOMAZ (203 Česká republika, domácí), Roman MIKLÍK (203 Česká republika, domácí), Milan HROMADKA (203 Česká republika), Ivo VARVAROVSKY (203 Česká republika), Jiří JARKOVSKÝ (203 Česká republika, domácí), Frantisek TOUSEK (203 Česká republika), Bohumil MAJTAN (203 Česká republika), Stanislav SIMEK (203 Česká republika), Marian BRANNY (203 Česká republika), Jan MROZEK (203 Česká republika) a Petr WIDIMSKY (203 Česká republika)

Vydání

International Journal of Cardiology, Clare, Elsevier Ireland Ltd. 2020, 0167-5273

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.164

Kód RIV

RIV/00216224:14110/20:00116817

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijcard.2020.06.067

UT WoS

000580586000001

Klíčová slova anglicky

Acute myocardial infarction; Primary percutaneous coronary intervention; Periprocedural myocardial infarction; Prognosis

Štítky

14110115, 14110211, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 7. 2023 12:59, Mgr. Tereza Miškechová

Anotace

V originále

Background: The prognostic significance of periprocedural myocardial infarction (MI) remains controversial. Methods and results: The study aims to investigate the incidence of periprocedural MI in the era of high sensitivity diagnostic markers and intense antithrombotics, and its impact on early outcomes of patients with acute MI treated with primary angioplasty (pPCI). Data from the PRAGUE-18 (prasugrel versus ticagrelor in pPCI) study were analyzed. The primary net-clinical endpoint (EP) included death, spontaneous MI, stroke, severe bleeding, and revascularization at day 7. The key secondary efficacy EP included cardiovascular death, spontaneous MI, and stroke within 30 days. The incidence of peri-pPCI MI was 2.3% (N = 28) in 1230 study patients. The net-clinical EP occurred in 10.7% of patients with, and in 3.6% of patients without, peri-pPCI MI (HR 2.92; 95% CI 0.91-9.38; P = 0.059). The key efficacy EP was 10.7% and 3.2%, respectively (HR 3.44; 95% CI 1.06-11.13; P = 0.028). Patients with periprocedural MI were at a higher risk of spontaneous MI (HR 6.19; 95% CI 1.41-27.24; P = 0.006) and stent thrombosis (HR 10.77; 95% CI 2.29-50.70; P = 0.003) within 30 days. Age, hyperlipidemia, multi-vessel disease, post-procedural TIMI <3, pPCI on circumflex coronary artery, and periprocedural GP IIb/IIIa inhibitor were independent predictors of peri-pPCI MI. Conclusions: In the era of intense antithrombotic therapy, the occurrence of peri-pPCI MI is despite highly sensitive diagnostic markers a rare complication, and is associated with an increased risk of early reinfarction and stent thrombosis. (C) 2020 Elsevier B.V. All rights reserved.

Návaznosti

LM2018128, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Akronym: CZECRIN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Český národní uzel Evropské sítě infrastruktur klinického výzkumu (CZECRIN)

Citovat

DUSEK, Jaroslav, Zuzana MOTOVSKA, Ota HLINOMAZ, Roman MIKLÍK, Milan HROMADKA, Ivo VARVAROVSKY, Jiří JARKOVSKÝ, Frantisek TOUSEK, Bohumil MAJTAN, Stanislav SIMEK, Marian BRANNY, Jan MROZEK a Petr WIDIMSKY. The prognostic significance of periprocedural infarction in the era of potent antithrombotic therapy. The PRAGUE-18 substudy. International Journal of Cardiology. Clare: Elsevier Ireland Ltd., 2020, roč. 319, NOV 2020, s. 1-6. ISSN 0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2020.06.067.

@article{1688915,
   author = {Dusek, Jaroslav and Motovska, Zuzana and Hlinomaz, Ota and Miklík, Roman and Hromadka, Milan and Varvarovsky, Ivo and Jarkovský, Jiří and Tousek, Frantisek and Majtan, Bohumil and Simek, Stanislav and Branny, Marian and Mrozek, Jan and Widimsky, Petr},
   article_location = {Clare},
   article_number = {NOV 2020},
   doi = {http://dx.doi.org/10.1016/j.ijcard.2020.06.067},
   keywords = {Acute myocardial infarction; Primary percutaneous coronary intervention; Periprocedural myocardial infarction; Prognosis},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {The prognostic significance of periprocedural infarction in the era of potent antithrombotic therapy. The PRAGUE-18 substudy},
   url = {https://www.sciencedirect.com/science/article/pii/S0167527320334458?via%3Dihub},
   volume = {319},
   year = {2020}
}

TY  - JOUR
ID  - 1688915
AU  - Dusek, Jaroslav - Motovska, Zuzana - Hlinomaz, Ota - Miklík, Roman - Hromadka, Milan - Varvarovsky, Ivo - Jarkovský, Jiří - Tousek, Frantisek - Majtan, Bohumil - Simek, Stanislav - Branny, Marian - Mrozek, Jan - Widimsky, Petr
PY  - 2020
TI  - The prognostic significance of periprocedural infarction in the era of potent antithrombotic therapy. The PRAGUE-18 substudy
JF  - International Journal of Cardiology
VL  - 319
IS  - NOV 2020
SP  - 1-6
EP  - 1-6
PB  - Elsevier Ireland Ltd.
SN  - 01675273
KW  - Acute myocardial infarction
KW  - Primary percutaneous coronary intervention
KW  - Periprocedural myocardial infarction
KW  - Prognosis
UR  - https://www.sciencedirect.com/science/article/pii/S0167527320334458?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0167527320334458?via%3Dihub
N2  - Background: The prognostic significance of periprocedural myocardial infarction (MI) remains controversial. Methods and results: The study aims to investigate the incidence of periprocedural MI in the era of high sensitivity diagnostic markers and intense antithrombotics, and its impact on early outcomes of patients with acute MI treated with primary angioplasty (pPCI). Data from the PRAGUE-18 (prasugrel versus ticagrelor in pPCI) study were analyzed. The primary net-clinical endpoint (EP) included death, spontaneous MI, stroke, severe bleeding, and revascularization at day 7. The key secondary efficacy EP included cardiovascular death, spontaneous MI, and stroke within 30 days. The incidence of peri-pPCI MI was 2.3% (N = 28) in 1230 study patients. The net-clinical EP occurred in 10.7% of patients with, and in 3.6% of patients without, peri-pPCI MI (HR 2.92; 95% CI 0.91-9.38; P = 0.059). The key efficacy EP was 10.7% and 3.2%, respectively (HR 3.44; 95% CI 1.06-11.13; P = 0.028). Patients with periprocedural MI were at a higher risk of spontaneous MI (HR 6.19; 95% CI 1.41-27.24; P = 0.006) and stent thrombosis (HR 10.77; 95% CI 2.29-50.70; P = 0.003) within 30 days. Age, hyperlipidemia, multi-vessel disease, post-procedural TIMI <3, pPCI on circumflex coronary artery, and periprocedural GP IIb/IIIa inhibitor were independent predictors of peri-pPCI MI. Conclusions: In the era of intense antithrombotic therapy, the occurrence of peri-pPCI MI is despite highly sensitive diagnostic markers a rare complication, and is associated with an increased risk of early reinfarction and stent thrombosis. (C) 2020 Elsevier B.V. All rights reserved.
ER  -

DUSEK, Jaroslav, Zuzana MOTOVSKA, Ota HLINOMAZ, Roman MIKLÍK, Milan HROMADKA, Ivo VARVAROVSKY, Jiří JARKOVSKÝ, Frantisek TOUSEK, Bohumil MAJTAN, Stanislav SIMEK, Marian BRANNY, Jan MROZEK a Petr WIDIMSKY. The prognostic significance of periprocedural infarction in the era of potent antithrombotic therapy. The PRAGUE-18 substudy. \textit{International Journal of Cardiology}. Clare: Elsevier Ireland Ltd., 2020, roč.~319, NOV 2020, s.~1-6. ISSN~0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2020.06.067.

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