Mitigation of Exercise Oscillatory Ventilation Score by Cardiac
Resynchronization Therapy

J 2020

Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy

ČUNDRLE, Ivan, Bruce D. JOHNSON, Robert F. REA, Christopher G. SCOTT, Virend K. SOMERS et. al.

Základní údaje

Originální název

Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy

Autoři

ČUNDRLE, Ivan (203 Česká republika, domácí), Bruce D. JOHNSON (840 Spojené státy), Robert F. REA (840 Spojené státy), Christopher G. SCOTT (840 Spojené státy), Virend K. SOMERS (840 Spojené státy) a Lyle J. OLSON (840 Spojené státy, garant)

Vydání

JOURNAL OF CARDIAC FAILURE, PHILADELPHIA, CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2020, 1071-9164

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.712

Kód RIV

RIV/00216224:14110/20:00116819

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.cardfail.2020.03.006

UT WoS

000579894900005

Klíčová slova anglicky

Exercise oscillatory ventilation; heart failure; CO2 chemosensitivity; pacing

Štítky

14110122, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 11. 2020 14:07, Mgr. Tereza Miškechová

Anotace

V originále

Background: Exercise oscillatory ventilation (EOV) is a consequence of ventilatory control system instability and is commonly observed in patients with advanced heart failure (HF); it is associated with adverse prognosis. The goal of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) on oscillatory ventilation as quantified by a proposed EOV score. Methods and Results: Consecutive patients with HF (N = 35) who underwent clinically indicated CRT, cardiopulmonary exercise testing and carbon dioxide (CO2) chemosensitivity by rebreathe before and 4-6 months after CRT were included in this post hoc analysis. With CRT, EOV scores improved in 22 patients (63%). In these patients, left ventricular ejection fraction, left atrial volume, brain natriuretic peptide concentration, and CO2 chemosensitivity significantly improved after CRT (P < 0.05). Furthermore, minute ventilation per unit CO2 production significantly decreased, and end-tidal CO2 increased at rest and at peak exercise post-CRT. Multiple regression analysis showed only the change of CO2 chemosensitivity to be significantly associated with the improvement of the EOV score (b = 0.64; F = 11.3; P = 0.004). In the group without EOV score improvement (n = 13), though left ventricular ejection fraction significantly increased with CRT (P = 0.015), no significant changes in ventilation or gas exchange were observed. Conclusion: The EOV score was mitigated by CRT and was associated with decreased CO2 chemosensitivity.

Citovat

ČUNDRLE, Ivan, Bruce D. JOHNSON, Robert F. REA, Christopher G. SCOTT, Virend K. SOMERS a Lyle J. OLSON. Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy. JOURNAL OF CARDIAC FAILURE. PHILADELPHIA: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2020, roč. 26, č. 10, s. 832-840. ISSN 1071-9164. Dostupné z: https://dx.doi.org/10.1016/j.cardfail.2020.03.006.

@article{1688925,
   author = {Čundrle, Ivan and Johnson, Bruce D. and Rea, Robert F. and Scott, Christopher G. and Somers, Virend K. and Olson, Lyle J.},
   article_location = {PHILADELPHIA},
   article_number = {10},
   doi = {http://dx.doi.org/10.1016/j.cardfail.2020.03.006},
   keywords = {Exercise oscillatory ventilation; heart failure; CO2 chemosensitivity; pacing},
   language = {eng},
   issn = {1071-9164},
   journal = {JOURNAL OF CARDIAC FAILURE},
   title = {Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy},
   url = {https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub},
   volume = {26},
   year = {2020}
}

TY  - JOUR
ID  - 1688925
AU  - Čundrle, Ivan - Johnson, Bruce D. - Rea, Robert F. - Scott, Christopher G. - Somers, Virend K. - Olson, Lyle J.
PY  - 2020
TI  - Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy
JF  - JOURNAL OF CARDIAC FAILURE
VL  - 26
IS  - 10
SP  - 832-840
EP  - 832-840
PB  - CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
SN  - 10719164
KW  - Exercise oscillatory ventilation
KW  - heart failure
KW  - CO2 chemosensitivity
KW  - pacing
UR  - https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1071916419307547?via%3Dihub
N2  - Background: Exercise oscillatory ventilation (EOV) is a consequence of ventilatory control system instability and is commonly observed in patients with advanced heart failure (HF); it is associated with adverse prognosis. The goal of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) on oscillatory ventilation as quantified by a proposed EOV score. Methods and Results: Consecutive patients with HF (N = 35) who underwent clinically indicated CRT, cardiopulmonary exercise testing and carbon dioxide (CO2) chemosensitivity by rebreathe before and 4-6 months after CRT were included in this post hoc analysis. With CRT, EOV scores improved in 22 patients (63%). In these patients, left ventricular ejection fraction, left atrial volume, brain natriuretic peptide concentration, and CO2 chemosensitivity significantly improved after CRT (P < 0.05). Furthermore, minute ventilation per unit CO2 production significantly decreased, and end-tidal CO2 increased at rest and at peak exercise post-CRT. Multiple regression analysis showed only the change of CO2 chemosensitivity to be significantly associated with the improvement of the EOV score (b = 0.64; F = 11.3; P = 0.004). In the group without EOV score improvement (n = 13), though left ventricular ejection fraction significantly increased with CRT (P = 0.015), no significant changes in ventilation or gas exchange were observed. Conclusion: The EOV score was mitigated by CRT and was associated with decreased CO2 chemosensitivity.
ER  -

ČUNDRLE, Ivan, Bruce D. JOHNSON, Robert F. REA, Christopher G. SCOTT, Virend K. SOMERS a Lyle J. OLSON. Mitigation of Exercise Oscillatory Ventilation Score by Cardiac Resynchronization Therapy. \textit{JOURNAL OF CARDIAC FAILURE}. PHILADELPHIA: CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2020, roč.~26, č.~10, s.~832-840. ISSN~1071-9164. Dostupné z: https://dx.doi.org/10.1016/j.cardfail.2020.03.006.

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