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@proceedings{1689309,
author = {Konečný, Štefan and Dosedělová, Věra and Ďurč, Pavol and Dolina, Jiří and Foret, František and Kubáň, Petr},
booktitle = {EUG Week 2020},
keywords = {saliva; gastroesophageal reflux disease; bile acids; ions},
language = {eng},
title = {Analysis of ions and organic acids in saliva in diagnostics of gastroesophageal reflux disease},
year = {2020}
}
TY - CONF
ID - 1689309
AU - Konečný, Štefan - Dosedělová, Věra - Ďurč, Pavol - Dolina, Jiří - Foret, František - Kubáň, Petr
PY - 2020
TI - Analysis of ions and organic acids in saliva in diagnostics of gastroesophageal reflux disease
KW - saliva
KW - gastroesophageal reflux disease
KW - bile acids
KW - ions
N2 - Introduction: Gastroesophageal reflux disease (GERD) is a disease caused by backflow of gastric contents into the esophagus due to the failure of physiological antireflux mechanisms and can lead to esophageal and extraesophageal symptomatology. At the current time, the gold standard in diagnostics of GERD is 24-hour multichannel intraluminal impedance and pH monitoring (MII-pH) that is invasive, time consuming and expensive diagnostic method with not clear relevance in diagnostics of extraesophageal reflux (EER) and there is a need for new faster, cheaper and more sensitive diagnostic method for detection of EER. New potential target in diagnostic of GERD is saliva. One of the saliva’s protective mechanism during a reflux episode is neutralization of gastric acid by various buffering systems. Bicarbonate and phosphate constitute major salivary buffering components. Since reflux episodes occur more frequently and have a longer duration in patients having GERD, our study investigates the hypothesis that bicarbonate and phosphate ions might be elevated in saliva.
ER -
KONEČNÝ, Štefan, Věra DOSEDĚLOVÁ, Pavol ĎURČ, Jiří DOLINA, František FORET a Petr KUBÁŇ. Analysis of ions and organic acids in saliva in diagnostics of gastroesophageal reflux disease. In \textit{EUG Week 2020}. 2020.
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