ŠÁNA, Jiří, Andrej BEŠŠE and ondřej SLABÝ. MicroRNAs in the Molecular Pathology of Gliomas. Online. In Sedo A., Mentlein R. Glioma Cell Biology. 1st ed. Vienna: Springer, Vienna, 2014, p. 77-116, 39 pp. ISBN 978-3-7091-1430-8. Available from: https://dx.doi.org/10.1007/978-3-7091-1431-5_4.
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Basic information
Original name MicroRNAs in the Molecular Pathology of Gliomas
Authors ŠÁNA, Jiří, Andrej BEŠŠE and ondřej SLABÝ.
Edition 1. vyd. Vienna, Glioma Cell Biology, p. 77-116, 39 pp. 2014.
Publisher Springer, Vienna
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30204 Oncology
Country of publisher Austria
Confidentiality degree is not subject to a state or trade secret
Publication form electronic version available online
WWW URL
Organization unit Central European Institute of Technology
ISBN 978-3-7091-1430-8
Doi http://dx.doi.org/10.1007/978-3-7091-1431-5_4
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 11/11/2020 13:53.
Abstract
MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs that act as posttranscriptional regulators of gene expression. Dysregulation of these molecules has been observed in many types of cancers. Altered expression levels of several miRNAs were identified also in gliomas. It was been frequently shown that miRNAs are involved in core signaling pathways, which play key roles in cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis, and stem cell behavior. Therefore, miRNAs have a great potential to act as new class of diagnostic, prognostic, and predictive biomarkers as well as promising therapeutic targets in gliomas. Here, we summarize the current knowledge about miRNAs significance in glioma molecular pathology, with special focus on their involvement in core signaling pathways, their roles in drug resistance, and their potential clinical implications.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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