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@inbook{1692177, author = {Šána, Jiří and Bešše, Andrej and slabý, ondřej}, address = {Vienna}, booktitle = {Glioma Cell Biology}, doi = {http://dx.doi.org/10.1007/978-3-7091-1431-5_4}, edition = {1.}, editor = {Sedo A., Mentlein R.}, howpublished = {elektronická verze "online"}, language = {eng}, location = {Vienna}, isbn = {978-3-7091-1430-8}, pages = {77-116}, publisher = {Springer, Vienna}, title = {MicroRNAs in the Molecular Pathology of Gliomas}, url = {https://link.springer.com/chapter/10.1007/978-3-7091-1431-5_4#citeas}, year = {2014} }
TY - CHAP ID - 1692177 AU - Šána, Jiří - Bešše, Andrej - slabý, ondřej PY - 2014 TI - MicroRNAs in the Molecular Pathology of Gliomas PB - Springer, Vienna CY - Vienna SN - 9783709114308 UR - https://link.springer.com/chapter/10.1007/978-3-7091-1431-5_4#citeas N2 - MicroRNAs (miRNAs) are endogenously expressed small noncoding RNAs that act as posttranscriptional regulators of gene expression. Dysregulation of these molecules has been observed in many types of cancers. Altered expression levels of several miRNAs were identified also in gliomas. It was been frequently shown that miRNAs are involved in core signaling pathways, which play key roles in cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis, and stem cell behavior. Therefore, miRNAs have a great potential to act as new class of diagnostic, prognostic, and predictive biomarkers as well as promising therapeutic targets in gliomas. Here, we summarize the current knowledge about miRNAs significance in glioma molecular pathology, with special focus on their involvement in core signaling pathways, their roles in drug resistance, and their potential clinical implications. ER -
ŠÁNA, Jiří, Andrej BEŠŠE and ondřej SLABÝ. MicroRNAs in the Molecular Pathology of Gliomas. Online. In Sedo A., Mentlein R. \textit{Glioma Cell Biology}. 1st ed. Vienna: Springer, Vienna, 2014, p.~77-116, 39 pp. ISBN~978-3-7091-1430-8. Available from: https://dx.doi.org/10.1007/978-3-7091-1431-5\_{}4.
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