Uveal melanoma - testing of abnormalities of chromosome 3 and 8
in the Czech Republic

J 2020

Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic

MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ et. al.

Základní údaje

Originální název

Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic

Autoři

MATUŠKOVÁ, Veronika (203 Česká republika, garant, domácí), Pavla HORŇÁČKOVÁ (203 Česká republika, domácí), Radoslava UHMANNOVÁ (203 Česká republika), Lenka ZLÁMALÍKOVÁ (203 Česká republika, domácí), Květoslava LIŠKOVÁ (203 Česká republika, domácí), Michal UHER (203 Česká republika, domácí) a Eva VLKOVÁ (203 Česká republika, domácí)

Vydání

Biomedical Papers, Olomouc, Univerzita Palackého v Olomouci, 2020, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30207 Ophthalmology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.245

Kód RIV

RIV/00216224:14110/20:00117059

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5507/bp.2019.037

UT WoS

000604951200008

Klíčová slova anglicky

uveal melanoma; chromosome 3; chromosome 8; CISH; FISH; progression-free survival

Štítky

14110219, 14110230, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 1. 2021 09:55, Mgr. Tereza Miškechová

Anotace

V originále

Aim: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples of enucleated eyes with uveal melanoma in the Czech population. Methods: This is a retrospective study of 52 enucleated eyes. Chromosome 3 and 8 status were tested by CISH, and in a few samples FISH was used. The correlation between monosomy 3 and gain of chromosome 8 and clinical features (histopathological type, size of the tumour) were evaluated. A follow up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was calculated. Results: There were 52 patients, 27 men (51.9%) and 25 women (48.1%) enrolled in our study group. The mean age was 63 ± 14 years. Loss of the one copy of chromosome 3 (monosomy 3) was detected in 26 (50.0%) patients, monosomy 8 was present in 34.6% of patients with monosomy 3. After 5 years there were no metastases in 82% of patients without monosomy 3 as opposed to 40% of patients with monosomy 3. We confirmed a statistically significant association between progression free survival (PFS) and the presence of monosomy 3 (P=0.017). The association between PFS and gain of chromosome 8 was significant as well (0.010). Conclusions: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma.

Citovat

MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ, Michal UHER a Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2020, roč. 164, č. 4, s. 401-409. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.037.

@article{1698697,
   author = {Matušková, Veronika and Horňáčková, Pavla and Uhmannová, Radoslava and Zlámalíková, Lenka and Lišková, Květoslava and Uher, Michal and Vlková, Eva},
   article_location = {Olomouc},
   article_number = {4},
   doi = {http://dx.doi.org/10.5507/bp.2019.037},
   keywords = {uveal melanoma; chromosome 3; chromosome 8; CISH; FISH; progression-free survival},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166},
   volume = {164},
   year = {2020}
}

TY  - JOUR
ID  - 1698697
AU  - Matušková, Veronika - Horňáčková, Pavla - Uhmannová, Radoslava - Zlámalíková, Lenka - Lišková, Květoslava - Uher, Michal - Vlková, Eva
PY  - 2020
TI  - Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic
JF  - Biomedical Papers
VL  - 164
IS  - 4
SP  - 401-409
EP  - 401-409
PB  - Univerzita Palackého v Olomouci
SN  - 12138118
KW  - uveal melanoma
KW  - chromosome 3
KW  - chromosome 8
KW  - CISH
KW  - FISH
KW  - progression-free survival
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166
L2  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166
N2  - Aim: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples of enucleated eyes with uveal melanoma in the Czech population. Methods: This is a retrospective study of 52 enucleated eyes. Chromosome 3 and 8 status were tested by CISH, and in a few samples FISH was used. The correlation between monosomy 3 and gain of chromosome 8 and clinical features (histopathological type, size of the tumour) were evaluated. A follow up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was calculated. Results: There were 52 patients, 27 men (51.9%) and 25 women (48.1%) enrolled in our study group. The mean age was 63 ± 14 years. Loss of the one copy of chromosome 3 (monosomy 3) was detected in 26 (50.0%) patients, monosomy 8 was present in 34.6% of patients with monosomy 3. After 5 years there were no metastases in 82% of patients without monosomy 3 as opposed to 40% of patients with monosomy 3. We confirmed a statistically significant association between progression free survival (PFS) and the presence of monosomy 3 (P=0.017). The association between PFS and gain of chromosome 8 was significant as well (0.010). Conclusions: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma.
ER  -

MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ, Michal UHER a Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2020, roč.~164, č.~4, s.~401-409. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.037.

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