DONNELLY, J. P., S. C. CHEN, C. A. KAUFFMAN, W. J. STEINBACH, J. W. BADDLEY, P. E. VERWEIJ, C. J. CLANCY, J. R. WINGARD, S. R. LOCKHART, A. H. GROLL, T. C.. SORRELL, M. BASSETTI, H. AKAN, B. D. ALEXANDER, D. ANDES, E. AZOULAY, R. BIALEK, R. W. BRADSHER, S. BRETAGNE, T. CALANDRA, A. M. CALIENDO, E. CASTAGNOLA, M. CRUCIANI, M. CUENCA-ESTRELLA, C. F. DECKER, S. R. DESAI, B. FISHER, T. HARRISON, C. P. HEUSSEL, H. E. JENSEN, C. C. KIBBLER, D. P. KONTOYIANNIS, B. J. KULLBERG, K. LAGROU, F. LAMOTH, T. LEHRNBECHER, J. LOEFFLER, O. LORTHOLARY, J. MAERTENS, O.. MARCHETTI, K. A. MARR, H. MASUR, J. F. MEIS, C. O. MORRISEY, M. NUCCI, L. OSTROSKY-ZEICHNER, L. PAGANO, T. F. PATTERSON, J. R. PERFECT, Zdeněk RÁČIL, E. ROILIDES, M. RUHNKE, C. S. PROKOP, S. SHOHAM, M. A. SLAVIN, D. A. STEVENS, G. R. THOMPSON, J. A. VAZQUEZ, C. VISCOLI, T. J. WALSH, A. WARRIS, L. J. WHEAT, P. L. WHITE, T. E. ZAOUTIS and P. G. PAPPAS. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clinical Infectious Diseases. Chicago, USA: The University of Chicago Press, 2020, vol. 71, No 6, p. 1367-1376. ISSN 1058-4838. Available from: https://dx.doi.org/10.1093/cid/ciz1008.
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Original name Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium
Authors DONNELLY, J. P. (guarantor), S. C. CHEN, C. A. KAUFFMAN, W. J. STEINBACH, J. W. BADDLEY, P. E. VERWEIJ, C. J. CLANCY, J. R. WINGARD, S. R. LOCKHART, A. H. GROLL, T. C.. SORRELL, M. BASSETTI, H. AKAN, B. D. ALEXANDER, D. ANDES, E. AZOULAY, R. BIALEK, R. W. BRADSHER, S. BRETAGNE, T. CALANDRA, A. M. CALIENDO, E. CASTAGNOLA, M. CRUCIANI, M. CUENCA-ESTRELLA, C. F. DECKER, S. R. DESAI, B. FISHER, T. HARRISON, C. P. HEUSSEL, H. E. JENSEN, C. C. KIBBLER, D. P. KONTOYIANNIS, B. J. KULLBERG, K. LAGROU, F. LAMOTH, T. LEHRNBECHER, J. LOEFFLER, O. LORTHOLARY, J. MAERTENS, O.. MARCHETTI, K. A. MARR, H. MASUR, J. F. MEIS, C. O. MORRISEY, M. NUCCI, L. OSTROSKY-ZEICHNER, L. PAGANO, T. F. PATTERSON, J. R. PERFECT, Zdeněk RÁČIL (203 Czech Republic, belonging to the institution), E. ROILIDES, M. RUHNKE, C. S. PROKOP, S. SHOHAM, M. A. SLAVIN, D. A. STEVENS, G. R. THOMPSON, J. A. VAZQUEZ, C. VISCOLI, T. J. WALSH, A. WARRIS, L. J. WHEAT, P. L. WHITE, T. E. ZAOUTIS and P. G. PAPPAS.
Edition Clinical Infectious Diseases, Chicago, USA, The University of Chicago Press, 2020, 1058-4838.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30303 Infectious Diseases
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 9.079
RIV identification code RIV/00216224:14110/20:00117062
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1093/cid/ciz1008
UT WoS 000582709700003
Keywords in English consensus; definitions; invasive fungal diseases; diagnosis; research
Tags 14110212, rivok
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 24/11/2020 10:29.
Abstract
Background Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell or solid organ transplants. With newer diagnostic techniques available, it was clear that an update of these definitions was essential. Methods To achieve this, 10 working groups looked closely at imaging, laboratory diagnosis, and special populations at risk of IFD. A final version of the manuscript was agreed upon after the groups' findings were presented at a scientific symposium and after a 3-month period for public comment. There were several rounds of discussion before a final version of the manuscript was approved. Results There is no change in the classifications of "proven," "probable," and "possible" IFD, although the definition of "probable" has been expanded and the scope of the category "possible" has been diminished. The category of proven IFD can apply to any patient, regardless of whether the patient is immunocompromised. The probable and possible categories are proposed for immunocompromised patients only, except for endemic mycoses. Conclusions These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk. European Organization for Research and Treatment of Cancer and the Mycoses Study Group definitions for probable invasive fungal disease now include solid organ transplant, hematologic malignancy, graft-versus-host disease, the reverse halo sign, revised thresholds for galactomannan, Aspergillus polymerase chain reaction, and definitions for candidiasis, cryptococcosis, non-human immunodeficiency viirus-associated pneumocystosis, and endemic mycoses.
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