Comparison of continuous versus intermittent enteral nutrition
in critically ill patients (COINN): study protocol for a
randomized comparative effectiveness trial

J 2020

Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial

HRDÝ, Ondřej; Kamil VRBICA; Eva STRAŽEVSKÁ; Petr SUK; Lenka SOUČKOVÁ et al.

Základní údaje

Originální název

Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial

Název česky

Porovnání kontinuální a intermitentní enterální výživy u kriticky nemocných pacientů (COINN): protokol randomizované komparativní studie efektivity

Autoři

HRDÝ, Ondřej; Kamil VRBICA; Eva STRAŽEVSKÁ; Petr SUK; Lenka SOUČKOVÁ; Radka ŠTĚPÁNOVÁ; Igor SAS a Roman GÁL

Vydání

Trials, London, BioMed Central, 2020, 1745-6215

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30221 Critical care medicine and Emergency medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.279

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00117089

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

intezívní péče; průjem; enterální výživa; žaludeční reziduální objem; jednotka intenzívní péče

Klíčová slova anglicky

Critical Care; Diarrhoea; Enteral nutrition; Gastric residual volume; Intensive care unit.

Štítky

14110233, 14110516, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 5. 2021 14:19, Mgr. Tereza Miškechová

Anotace

ORIG CZ

V originále

BackgroundEnteral nutrition is part of the treatment of critically ill patients. Administration of enteral nutrition may be associated with signs of intolerance, such as high gastric residual volumes, diarrhea, and vomiting. Clinical trials regarding the effects of the mode of administration of enteral nutrition on the occurrence of these complications have yielded conflicting results. This trial aims to investigate whether the mode of administration of enteral nutrition affects the time to reach nutritional targets, intolerance, and complications.MethodsCOINN is a randomized, monocentric study for critically ill adult patients receiving enteral nutrition. Patients will be randomly assigned to two groups receiving (1) continuous or (2) intermittent administration of enteral nutrition. Enhancement of enteral nutrition will depend on signs of tolerance, mainly the gastric residual volume. The primary outcome will be the time to reach the energetic target. Secondary outcomes will be the time to reach the protein target, tolerance, complications, hospital and ICU lengths of stay, and 28-day mortality.DiscussionThis trial aims to evaluate whether the mode of application of enteral nutrition affects the time to reach nutritional targets, signs of intolerance, and complications.Trial registrationClinicalTrials.gov NCT03573453. Registered on 29 June 2018.

Česky

Protokol klinické studie porovnávajíc dva způsoby podávání enterální výživy. Zaměřeno především na toleraci a komplikace enterální výživy.

Návaznosti

LM2018128, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Akronym: CZECRIN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Český národní uzel Evropské sítě infrastruktur klinického výzkumu (CZECRIN)

Přiložené soubory

s13063-020-04866-2.pdf

Požádat o autorskou verzi souboru

Citovat

HRDÝ, Ondřej; Kamil VRBICA; Eva STRAŽEVSKÁ; Petr SUK; Lenka SOUČKOVÁ; Radka ŠTĚPÁNOVÁ; Igor SAS a Roman GÁL. Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial. Trials. London: BioMed Central, 2020, roč. 21, č. 1, s. 1-10. ISSN 1745-6215. Dostupné z: https://doi.org/10.1186/s13063-020-04866-2.

@article{1699400,
   author = {Hrdý, Ondřej and Vrbica, Kamil and Straževská, Eva and Suk, Petr and Součková, Lenka and Štěpánová, Radka and Sas, Igor and Gál, Roman},
   article_location = {London},
   article_number = {1},
   doi = {https://doi.org/10.1186/s13063-020-04866-2},
   keywords = {Critical Care; Diarrhoea; Enteral nutrition; Gastric residual volume; Intensive care unit.},
   language = {eng},
   issn = {1745-6215},
   journal = {Trials},
   title = {Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial},
   url = {https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04866-2},
   volume = {21},
   year = {2020}
}

TY  - JOUR
ID  - 1699400
AU  - Hrdý, Ondřej - Vrbica, Kamil - Straževská, Eva - Suk, Petr - Součková, Lenka - Štěpánová, Radka - Sas, Igor - Gál, Roman
PY  - 2020
TI  - Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial
JF  - Trials
VL  - 21
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - BioMed Central
SN  - 17456215
KW  - Critical Care
KW  - Diarrhoea
KW  - Enteral nutrition
KW  - Gastric residual volume
KW  - Intensive care unit.
UR  - https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04866-2
L2  - https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04866-2
N2  - BackgroundEnteral nutrition is part of the treatment of critically ill patients. Administration of enteral nutrition may be associated with signs of intolerance, such as high gastric residual volumes, diarrhea, and vomiting. Clinical trials regarding the effects of the mode of administration of enteral nutrition on the occurrence of these complications have yielded conflicting results. This trial aims to investigate whether the mode of administration of enteral nutrition affects the time to reach nutritional targets, intolerance, and complications.MethodsCOINN is a randomized, monocentric study for critically ill adult patients receiving enteral nutrition. Patients will be randomly assigned to two groups receiving (1) continuous or (2) intermittent administration of enteral nutrition. Enhancement of enteral nutrition will depend on signs of tolerance, mainly the gastric residual volume. The primary outcome will be the time to reach the energetic target. Secondary outcomes will be the time to reach the protein target, tolerance, complications, hospital and ICU lengths of stay, and 28-day mortality.DiscussionThis trial aims to evaluate whether the mode of application of enteral nutrition affects the time to reach nutritional targets, signs of intolerance, and complications.Trial registrationClinicalTrials.gov NCT03573453. Registered on 29 June 2018.
ER  -

HRDÝ, Ondřej; Kamil VRBICA; Eva STRAŽEVSKÁ; Petr SUK; Lenka SOUČKOVÁ; Radka ŠTĚPÁNOVÁ; Igor SAS a Roman GÁL. Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial. \textit{Trials}. London: BioMed Central, 2020, roč.~21, č.~1, s.~1-10. ISSN~1745-6215. Dostupné z: https://doi.org/10.1186/s13063-020-04866-2.

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