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@article{1699499, author = {Hampl, Marek and Dumková, Jana and Kavková, Michaela and Dosedělová, Hana and Bryjová, Anna and Zahradníček, Oldřich and Pyszko, Martin and Macholan, Miloš and Zikmund, Tomáš and Kaiser, Jozef and Buchtová, marcela}, article_location = {Lausanne}, article_number = {July 2020}, doi = {http://dx.doi.org/10.3389/fcell.2020.00572}, keywords = {secondary palate; SHH; primary cilia; skeletogenesis; chameleon; reptile Frontiers}, language = {eng}, issn = {2296-634X}, journal = {Frontiers in Cell and Developmental Biology}, title = {Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon}, url = {https://www.frontiersin.org/articles/10.3389/fcell.2020.00572/full}, volume = {8}, year = {2020} }
TY - JOUR ID - 1699499 AU - Hampl, Marek - Dumková, Jana - Kavková, Michaela - Dosedělová, Hana - Bryjová, Anna - Zahradníček, Oldřich - Pyszko, Martin - Macholan, Miloš - Zikmund, Tomáš - Kaiser, Jozef - Buchtová, marcela PY - 2020 TI - Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon JF - Frontiers in Cell and Developmental Biology VL - 8 IS - July 2020 SP - 1-29 EP - 1-29 PB - Frontiers Media S.A. SN - 2296634X KW - secondary palate KW - SHH KW - primary cilia KW - skeletogenesis KW - chameleon KW - reptile Frontiers UR - https://www.frontiersin.org/articles/10.3389/fcell.2020.00572/full L2 - https://www.frontiersin.org/articles/10.3389/fcell.2020.00572/full N2 - Secondary palate development is characterized by the formation of two palatal shelves on the maxillary prominences, which fuse in the midline in mammalian embryos. However, in reptilian species, such as turtles, crocodilians, and lizards, the palatal shelves of the secondary palate develop to a variable extent and morphology. While in most Squamates, the palate is widely open, crocodilians develop a fully closed secondary palate. Here, we analyzed developmental processes that underlie secondary palate formation in chameleons, where large palatal shelves extend horizontally toward the midline. The growth of the palatal shelves continued during post-hatching stages and closure of the secondary palate can be observed in several adult animals. The massive proliferation of a multilayered oral epithelium and mesenchymal cells in the dorsal part of the palatal shelves underlined the initiation of their horizontal outgrowth, and was decreased later in development. The polarized cellular localization of primary cilia and Sonic hedgehog protein was associated with horizontal growth of the palatal shelves. Moreover, the development of large palatal shelves, supported by the pterygoid and palatine bones, was coupled with the shift in Meox2, Msx1, and Pax9 gene expression along the rostro-caudal axis. In conclusion, our results revealed distinctive developmental processes that contribute to the expansion and closure of the secondary palate in chameleons and highlighted divergences in palate formation across amniote species. ER -
HAMPL, Marek, Jana DUMKOVÁ, Michaela KAVKOVÁ, Hana DOSEDĚLOVÁ, Anna BRYJOVÁ, Oldřich ZAHRADNÍČEK, Martin PYSZKO, Miloš MACHOLAN, Tomáš ZIKMUND, Jozef KAISER a marcela BUCHTOVÁ. Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2020, roč.~8, July 2020, s.~1-29. ISSN~2296-634X. Dostupné z: https://dx.doi.org/10.3389/fcell.2020.00572.
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