2020
Developmental mechanisms driving complex tooth shape in reptiles
ŠULCOVÁ, Marie, Oldrich ZAHRADNICEK, Jana DUMKOVÁ, Hana DOSEDELOVA, Jan KŘIVÁNEK et. al.Základní údaje
Originální název
Developmental mechanisms driving complex tooth shape in reptiles
Autoři
ŠULCOVÁ, Marie (203 Česká republika, domácí), Oldrich ZAHRADNICEK, Jana DUMKOVÁ (203 Česká republika, domácí), Hana DOSEDELOVA, Jan KŘIVÁNEK (203 Česká republika, domácí), Marek HAMPL (203 Česká republika, domácí), Michaela KAVKOVA, Tomas ZIKMUND, Martina GREGOROVICOVA, David SEDMERA, Jozef KAISER, Abigail S. TUCKER a Marcela BUCHTOVÁ (203 Česká republika, garant, domácí)
Vydání
Developmental dynamics, Hoboken, Wiley, 2020, 1058-8388
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10602 Biology , Evolutionary biology
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 3.780
Kód RIV
RIV/00216224:14310/20:00114512
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000502529500001
Klíčová slova anglicky
chameleon; crocodile; enamel ridge; gecko; matriptase; Na; K-ATPase; nuclei shape; SHH; tooth shape
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 17. 2. 2023 12:16, Mgr. Marie Šípková, DiS.
Anotace
V originále
Background In mammals, odontogenesis is regulated by transient signaling centers known as enamel knots (EKs), which drive the dental epithelium shaping. However, the developmental mechanisms contributing to formation of complex tooth shape in reptiles are not fully understood. Here, we aim to elucidate whether signaling organizers similar to EKs appear during reptilian odontogenesis and how enamel ridges are formed. Results Morphological structures resembling the mammalian EK were found during reptile odontogenesis. Similar to mammalian primary EKs, they exhibit the presence of apoptotic cells and no proliferating cells. Moreover, expression of mammalian EK-specific molecules (SHH, FGF4, and ST14) and GLI2-negative cells were found in reptilian EK-like areas. 3D analysis of the nucleus shape revealed distinct rearrangement of the cells associated with enamel groove formation. This process was associated with ultrastructural changes and lipid droplet accumulation in the cells directly above the forming ridge, accompanied by alteration of membranous molecule expression (Na/K-ATPase) and cytoskeletal rearrangement (F-actin). Conclusions The final complex shape of reptilian teeth is orchestrated by a combination of changes in cell signaling, cell shape, and cell rearrangement. All these factors contribute to asymmetry in the inner enamel epithelium development, enamel deposition, ultimately leading to the formation of characteristic enamel ridges.
Návaznosti
GA17-14886S, projekt VaV |
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LM2015062, projekt VaV |
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LQ1601, projekt VaV |
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