High frequency oscillations in epileptic and non-epileptic
human hippocampus during a cognitive task

J 2020

High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task

PAIL, Martin, Jan CIMBALNIK, Robert ROMAN, Pavel DANIEL, Daniel Joel SHAW et. al.

Základní údaje

Originální název

High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task

Autoři

PAIL, Martin (203 Česká republika, garant, domácí), Jan CIMBALNIK (203 Česká republika), Robert ROMAN (203 Česká republika, domácí), Pavel DANIEL (203 Česká republika, domácí), Daniel Joel SHAW (826 Velká Británie a Severní Irsko, domácí), Jan CHRASTINA (203 Česká republika, domácí) a Milan BRÁZDIL (203 Česká republika, domácí)

Vydání

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2020, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.379

Kód RIV

RIV/00216224:14110/20:00117112

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-020-74306-3

UT WoS

000586485700005

Klíčová slova anglicky

epileptic and non-epileptic human hippocampus; cognitive task

Štítky

14110127, 14110131, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 2. 2021 12:56, Mgr. Tereza Miškechová

Anotace

V originále

Hippocampal high-frequency electrographic activity (HFOs) represents one of the major discoveries not only in epilepsy research but also in cognitive science over the past few decades. A fundamental challenge, however, has been the fact that physiological HFOs associated with normal brain function overlap in frequency with pathological HFOs. We investigated the impact of a cognitive task on HFOs with the aim of improving differentiation between epileptic and non-epileptic hippocampi in humans. Hippocampal activity was recorded with depth electrodes in 15 patients with focal epilepsy during a resting period and subsequently during a cognitive task. HFOs in ripple and fast ripple frequency ranges were evaluated in both conditions, and their rate, spectral entropy, relative amplitude and duration were compared in epileptic and non-epileptic hippocampi. The similarity of HFOs properties recorded at rest in epileptic and non-epileptic hippocampi suggests that they cannot be used alone to distinguish between hippocampi. However, both ripples and fast ripples were observed with higher rates, higher relative amplitudes and longer durations at rest as well as during a cognitive task in epileptic compared with non-epileptic hippocampi. Moreover, during a cognitive task, significant reductions of HFOs rates were found in epileptic hippocampi. These reductions were not observed in non-epileptic hippocampi. Our results indicate that although both hippocampi generate HFOs with similar features that probably reflect non-pathological phenomena, it is possible to differentiate between epileptic and non-epileptic hippocampi using a simple odd-ball task.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

PAIL, Martin, Jan CIMBALNIK, Robert ROMAN, Pavel DANIEL, Daniel Joel SHAW, Jan CHRASTINA a Milan BRÁZDIL. High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2020, roč. 10, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-74306-3.

@article{1699856,
   author = {Pail, Martin and Cimbalnik, Jan and Roman, Robert and Daniel, Pavel and Shaw, Daniel Joel and Chrastina, Jan and Brázdil, Milan},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-74306-3},
   keywords = {epileptic and non-epileptic human hippocampus; cognitive task},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task},
   url = {https://www.nature.com/articles/s41598-020-74306-3.pdf},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1699856
AU  - Pail, Martin - Cimbalnik, Jan - Roman, Robert - Daniel, Pavel - Shaw, Daniel Joel - Chrastina, Jan - Brázdil, Milan
PY  - 2020
TI  - High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task
JF  - Scientific reports
VL  - 10
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - epileptic and non-epileptic human hippocampus
KW  - cognitive task
UR  - https://www.nature.com/articles/s41598-020-74306-3.pdf
L2  - https://www.nature.com/articles/s41598-020-74306-3.pdf
N2  - Hippocampal high-frequency electrographic activity (HFOs) represents one of the major discoveries not only in epilepsy research but also in cognitive science over the past few decades. A fundamental challenge, however, has been the fact that physiological HFOs associated with normal brain function overlap in frequency with pathological HFOs. We investigated the impact of a cognitive task on HFOs with the aim of improving differentiation between epileptic and non-epileptic hippocampi in humans. Hippocampal activity was recorded with depth electrodes in 15 patients with focal epilepsy during a resting period and subsequently during a cognitive task. HFOs in ripple and fast ripple frequency ranges were evaluated in both conditions, and their rate, spectral entropy, relative amplitude and duration were compared in epileptic and non-epileptic hippocampi. The similarity of HFOs properties recorded at rest in epileptic and non-epileptic hippocampi suggests that they cannot be used alone to distinguish between hippocampi. However, both ripples and fast ripples were observed with higher rates, higher relative amplitudes and longer durations at rest as well as during a cognitive task in epileptic compared with non-epileptic hippocampi. Moreover, during a cognitive task, significant reductions of HFOs rates were found in epileptic hippocampi. These reductions were not observed in non-epileptic hippocampi. Our results indicate that although both hippocampi generate HFOs with similar features that probably reflect non-pathological phenomena, it is possible to differentiate between epileptic and non-epileptic hippocampi using a simple odd-ball task.
ER  -

PAIL, Martin, Jan CIMBALNIK, Robert ROMAN, Pavel DANIEL, Daniel Joel SHAW, Jan CHRASTINA a Milan BRÁZDIL. High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2020, roč.~10, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-74306-3.

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