Everolimus-related unilateral abdominal lymphedema in a renal
cancer patient A case report

J 2020

Everolimus-related unilateral abdominal lymphedema in a renal cancer patient A case report

HALÁMKOVÁ, Jana, Tomáš KAZDA, Dagmar ADAMKOVA-KRAKOROVA, Sylva RYBNÍČKOVÁ, Igor KISS et. al.

Základní údaje

Originální název

Everolimus-related unilateral abdominal lymphedema in a renal cancer patient A case report

Autoři

HALÁMKOVÁ, Jana (203 Česká republika, garant, domácí), Tomáš KAZDA (203 Česká republika, domácí), Dagmar ADAMKOVA-KRAKOROVA (203 Česká republika), Sylva RYBNÍČKOVÁ (203 Česká republika), Igor KISS (203 Česká republika, domácí) a Regina DEMLOVÁ (203 Česká republika, domácí)

Vydání

Medicine, Philadelphia, Lippincott Williams & Wilkins, 2020, 0025-7974

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.889

Kód RIV

RIV/00216224:14110/20:00117214

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/MD.0000000000022634

UT WoS

000589394700033

Klíčová slova anglicky

abdominal lymphedema; case report; everolimus-related adverse event; mammalian target of rapamycin inhibitors; renal cancer; unilateral lymphedema

Štítky

14110516, 14110522, 14110811, 14110812, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 12. 2020 13:31, Mgr. Tereza Miškechová

Anotace

V originále

Rationale: Unilateral manifestation of lymphedema during everolimus therapy has been described only rarely, mostly in transplant recipients. Patient concerns: We report the first case of a patient who developed unilateral abdominal lymphedema, during a short period of everolimus treatment for renal cancer. Diagnosis: The abdominal asymmetry occurred only on the right side of the abdomen, neither ultrasound nor CT scan detected ascites but showed enlargement of the abdominal wall. The Naranjo Adverse Drug Reaction Probability scale was evaluated, in this case, a score of 6 indicated a probable adverse reaction to everolimus. Interventions: Discontinuation of everolimus therapy led to immediate alleviation and reduction of the lymphedema, with worsening once again after initiating retreatment with everolimus at a reduced dose. Outcomes: The patient's lymphedema recovered after discontinuation of everolimus. Lessons: This rare case demonstrates the importance of the selection of mammalian target of rapamycin inhibitors using caution, especially for patients with a high risk of developing lymphedema.

Návaznosti

LM2018128, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Akronym: CZECRIN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Český národní uzel Evropské sítě infrastruktur klinického výzkumu (CZECRIN)

Citovat

HALÁMKOVÁ, Jana, Tomáš KAZDA, Dagmar ADAMKOVA-KRAKOROVA, Sylva RYBNÍČKOVÁ, Igor KISS a Regina DEMLOVÁ. Everolimus-related unilateral abdominal lymphedema in a renal cancer patient A case report. Medicine. Philadelphia: Lippincott Williams & Wilkins, 2020, roč. 99, č. 42, s. 1-4. ISSN 0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000022634.

@article{1703256,
   author = {Halámková, Jana and Kazda, Tomáš and AdamkovaandKrakorova, Dagmar and Rybníčková, Sylva and Kiss, Igor and Demlová, Regina},
   article_location = {Philadelphia},
   article_number = {42},
   doi = {http://dx.doi.org/10.1097/MD.0000000000022634},
   keywords = {abdominal lymphedema; case report; everolimus-related adverse event; mammalian target of rapamycin inhibitors; renal cancer; unilateral lymphedema},
   language = {eng},
   issn = {0025-7974},
   journal = {Medicine},
   title = {Everolimus-related unilateral abdominal lymphedema in a renal cancer patient A case report},
   url = {https://journals.lww.com/md-journal/Fulltext/2020/10160/Everolimus_related_unilateral_abdominal_lymphedema.33.aspx},
   volume = {99},
   year = {2020}
}

TY  - JOUR
ID  - 1703256
AU  - Halámková, Jana - Kazda, Tomáš - Adamkova-Krakorova, Dagmar - Rybníčková, Sylva - Kiss, Igor - Demlová, Regina
PY  - 2020
TI  - Everolimus-related unilateral abdominal lymphedema in a renal cancer patient A case report
JF  - Medicine
VL  - 99
IS  - 42
SP  - 1-4
EP  - 1-4
PB  - Lippincott Williams & Wilkins
SN  - 00257974
KW  - abdominal lymphedema
KW  - case report
KW  - everolimus-related adverse event
KW  - mammalian target of rapamycin inhibitors
KW  - renal cancer
KW  - unilateral lymphedema
UR  - https://journals.lww.com/md-journal/Fulltext/2020/10160/Everolimus_related_unilateral_abdominal_lymphedema.33.aspx
L2  - https://journals.lww.com/md-journal/Fulltext/2020/10160/Everolimus_related_unilateral_abdominal_lymphedema.33.aspx
N2  - Rationale: Unilateral manifestation of lymphedema during everolimus therapy has been described only rarely, mostly in transplant recipients. Patient concerns: We report the first case of a patient who developed unilateral abdominal lymphedema, during a short period of everolimus treatment for renal cancer. Diagnosis: The abdominal asymmetry occurred only on the right side of the abdomen, neither ultrasound nor CT scan detected ascites but showed enlargement of the abdominal wall. The Naranjo Adverse Drug Reaction Probability scale was evaluated, in this case, a score of 6 indicated a probable adverse reaction to everolimus. Interventions: Discontinuation of everolimus therapy led to immediate alleviation and reduction of the lymphedema, with worsening once again after initiating retreatment with everolimus at a reduced dose. Outcomes: The patient's lymphedema recovered after discontinuation of everolimus. Lessons: This rare case demonstrates the importance of the selection of mammalian target of rapamycin inhibitors using caution, especially for patients with a high risk of developing lymphedema.
ER  -

HALÁMKOVÁ, Jana, Tomáš KAZDA, Dagmar ADAMKOVA-KRAKOROVA, Sylva RYBNÍČKOVÁ, Igor KISS a Regina DEMLOVÁ. Everolimus-related unilateral abdominal lymphedema in a renal cancer patient A case report. \textit{Medicine}. Philadelphia: Lippincott Williams \&{} Wilkins, 2020, roč.~99, č.~42, s.~1-4. ISSN~0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000022634.

Podrobný výpis o publikaci