Individual differences in interoceptive accuracy and prediction
error in motor functional neurological disorders: A DTI study

J 2021

Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study

SOJKA, Petr, Ibai DIEZ, Martin BAREŠ a David L. PEREZ

Základní údaje

Originální název

Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study

Autoři

SOJKA, Petr (203 Česká republika, garant, domácí), Ibai DIEZ, Martin BAREŠ (203 Česká republika, domácí) a David L. PEREZ

Vydání

Human Brain Mapping, Hoboken, Wiley, 2021, 1065-9471

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.399

Kód RIV

RIV/00216224:14110/21:00120078

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/hbm.25304

UT WoS

000596132200001

Klíčová slova anglicky

conversion disorder; diffusion tensor imaging; dissociative seizures; DTI; functional movement disorder; interoception; psychogenic

Štítky

14110127, 14110222, 14110523, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 3. 2021 08:45, Mgr. Tereza Miškechová

Anotace

V originále

In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel-based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND-seiz; n = 21) or functional movement disorders (n = 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within-group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self-reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between-group interoceptive accuracy or FA differences. However, the FND-seiz subgroup compared to HCs showed decreased integrity in right-lateralized tracts: extreme capsule/inferior fronto-occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain-interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration-related fiber bundles. Right-lateralized limbic and associative tract disruptions distinguished FND-seiz from HCs.

Návaznosti

NV16-31457A, projekt VaV

Název: Neurobiologické mechanismy funkčních neurologických poruch

Citovat

SOJKA, Petr, Ibai DIEZ, Martin BAREŠ a David L. PEREZ. Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study. Human Brain Mapping. Hoboken: Wiley, 2021, roč. 42, č. 5, s. 1434-1445. ISSN 1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.25304.

@article{1705617,
   author = {Sojka, Petr and Diez, Ibai and Bareš, Martin and Perez, David L.},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/hbm.25304},
   keywords = {conversion disorder; diffusion tensor imaging; dissociative seizures; DTI; functional movement disorder; interoception; psychogenic},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain Mapping},
   title = {Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25304},
   volume = {42},
   year = {2021}
}

TY  - JOUR
ID  - 1705617
AU  - Sojka, Petr - Diez, Ibai - Bareš, Martin - Perez, David L.
PY  - 2021
TI  - Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study
JF  - Human Brain Mapping
VL  - 42
IS  - 5
SP  - 1434-1445
EP  - 1434-1445
PB  - Wiley
SN  - 10659471
KW  - conversion disorder
KW  - diffusion tensor imaging
KW  - dissociative seizures
KW  - DTI
KW  - functional movement disorder
KW  - interoception
KW  - psychogenic
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25304
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25304
N2  - In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel-based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND-seiz; n = 21) or functional movement disorders (n = 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within-group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self-reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between-group interoceptive accuracy or FA differences. However, the FND-seiz subgroup compared to HCs showed decreased integrity in right-lateralized tracts: extreme capsule/inferior fronto-occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain-interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration-related fiber bundles. Right-lateralized limbic and associative tract disruptions distinguished FND-seiz from HCs.
ER  -

SOJKA, Petr, Ibai DIEZ, Martin BAREŠ a David L. PEREZ. Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study. \textit{Human Brain Mapping}. Hoboken: Wiley, 2021, roč.~42, č.~5, s.~1434-1445. ISSN~1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.25304.

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