Temporally and sex-specific effects of maternal perinatal
stress on offspring cortical gyrification and mood in young
adulthood

J 2020

Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

MAREČKOVÁ, Klára, Amy MILES, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, Yuliya S. NIKOLOVA et. al.

Základní údaje

Originální název

Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Autoři

MAREČKOVÁ, Klára (203 Česká republika, garant, domácí), Amy MILES, Lenka ANDRÝSKOVÁ (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a Yuliya S. NIKOLOVA

Vydání

Human Brain mapping, Hoboken, Wiley, 2020, 1065-9471

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.038

Kód RIV

RIV/00216224:14740/20:00117301

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/hbm.25163

UT WoS

000574703300001

Klíčová slova anglicky

dysregulated mood; gyrification; magnetic resonance imaging; perinatal stress; prenatal birth cohort; sex; young adulthood

Štítky

CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 11:37, Ing. Jana Kuchtová

Anotace

V originále

Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f(2)= 0.19-0.38,p< .001), later perinatal stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f(2)= 0.10-0.19,p< .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r= 0.399,p= .006). These findings point out the long-term implications of perinatal stress exposure for cortical morphology and mood dysregulation.

Návaznosti

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

MAREČKOVÁ, Klára, Amy MILES, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a Yuliya S. NIKOLOVA. Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood. Human Brain mapping. Hoboken: Wiley, 2020, roč. 41, č. 17, s. 4866-4875. ISSN 1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.25163.

@article{1706897,
   author = {Marečková, Klára and Miles, Amy and Andrýsková, Lenka and Brázdil, Milan and Nikolova, Yuliya S.},
   article_location = {Hoboken},
   article_number = {17},
   doi = {http://dx.doi.org/10.1002/hbm.25163},
   keywords = {dysregulated mood; gyrification; magnetic resonance imaging; perinatal stress; prenatal birth cohort; sex; young adulthood},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain mapping},
   title = {Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood},
   url = {https://doi.org/10.1002/hbm.25163},
   volume = {41},
   year = {2020}
}

TY  - JOUR
ID  - 1706897
AU  - Marečková, Klára - Miles, Amy - Andrýsková, Lenka - Brázdil, Milan - Nikolova, Yuliya S.
PY  - 2020
TI  - Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood
JF  - Human Brain mapping
VL  - 41
IS  - 17
SP  - 4866-4875
EP  - 4866-4875
PB  - Wiley
SN  - 10659471
KW  - dysregulated mood
KW  - gyrification
KW  - magnetic resonance imaging
KW  - perinatal stress
KW  - prenatal birth cohort
KW  - sex
KW  - young adulthood
UR  - https://doi.org/10.1002/hbm.25163
L2  - https://doi.org/10.1002/hbm.25163
N2  - Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f(2)= 0.19-0.38,p< .001), later perinatal stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f(2)= 0.10-0.19,p< .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r= 0.399,p= .006). These findings point out the long-term implications of perinatal stress exposure for cortical morphology and mood dysregulation.
ER  -

MAREČKOVÁ, Klára, Amy MILES, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a Yuliya S. NIKOLOVA. Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood. \textit{Human Brain mapping}. Hoboken: Wiley, 2020, roč.~41, č.~17, s.~4866-4875. ISSN~1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.25163.

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