Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study

KATAJA, Anu, Tuukka TARVASMÄKI, Johan LASSUS, Alessandro SIONIS, Alexandre MEBAZAA, Kari PULKKI, Marek BANASZEWSKI, Valentina CARUBELLI, Mari HONGISTO, Ewa JANKOWSKA, Raija JURKKO, Toni JÄNTTI, Monika KASZTURA, John PARISSIS, Tuija SABELL, Jose SILVA-CARDOSO, Jindřich ŠPINAR, Heli TOLPPANEN a Veli-Pekka HARJOLA. Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study. International Journal of Cardiology. Clare: Elsevier, 2021, roč. 322, JAN 2021, s. 191-196. ISSN 0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2020.08.069.

Základní údaje

• Originální název: Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study
• Autoři: KATAJA, Anu (246 Finsko, garant), Tuukka TARVASMÄKI (246 Finsko), Johan LASSUS (246 Finsko), Alessandro SIONIS (724 Španělsko), Alexandre MEBAZAA (250 Francie), Kari PULKKI (246 Finsko), Marek BANASZEWSKI (616 Polsko), Valentina CARUBELLI (380 Itálie), Mari HONGISTO (246 Finsko), Ewa JANKOWSKA (616 Polsko), Raija JURKKO (246 Finsko), Toni JÄNTTI (246 Finsko), Monika KASZTURA (616 Polsko), John PARISSIS (300 Řecko), Tuija SABELL (246 Finsko), Jose SILVA-CARDOSO (620 Portugalsko), Jindřich ŠPINAR (203 Česká republika, domácí), Heli TOLPPANEN (246 Finsko) a Veli-Pekka HARJOLA (246 Finsko).
• Vydání: International Journal of Cardiology, Clare, Elsevier, 2021, 0167-5273.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30201 Cardiac and Cardiovascular systems
• Stát vydavatele: Irsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Impakt faktor: Impact factor: 4.039
• Kód RIV: RIV/00216224:14110/21:00120857
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.1016/j.ijcard.2020.08.069
• UT WoS: 000612679700043
• Klíčová slova anglicky: Cardiogenic shock; Inflammation; Procalcitonin; Interleukin 6; C-reactive protein
• Štítky: 14110115, rivok
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Background Inflammatory responses play an important role in the pathophysiology of cardiogenic shock (CS). The aim of this study was to investigate the kinetics of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in CS and to assess their relation to clinical presentation, other biochemical variables, and prognosis. Methods Levels of PCT, CRP and IL-6 were analyzed in serial plasma samples (0−120 h) from 183 patients in the CardShock study. The study population was dichotomized by PCT max ≥ and < 0.5 μg/L, and IL-6 and CRP max above/below median. Results PCT peaked already at 24 h [median PCT max 0.71 μg/L (IQR 0.24–3.4)], whereas CRP peaked later between 48 and 72 h [median CRP max 137 mg/L (59–247)]. PCT levels were significantly higher among non-survivors compared with survivors from 12 h on, as were CRP levels from 24 h on ( p < 0.001). PCT max ≥ 0.5 μg/L (60% of patients) was associated with clinical signs of systemic hypoperfusion, cardiac and renal dysfunction, acidosis, and higher levels of blood lactate, IL-6, growth-differentiation factor 15 (GDF-15), and CRP max. Similarly, IL-6 > median was associated with clinical signs and biochemical findings of systemic hypoperfusion. PCT max ≥ 0.5 μg/L and IL-6 > median were associated with increased 90-day mortality (50% vs. 30% and 57% vs. 22%, respectively; p < 0.01 for both), while CRP max showed no prognostic significance. The association of inflammatory markers with clinical infections was modest. Conclusions Inflammatory markers are highly related to signs of systemic hypoperfusion in CS. Moreover, high PCT and IL-6 levels are associated with poor prognosis.