Kinetics of procalcitonin, C-reactive protein and interleukin-6
in cardiogenic shock – Insights from the CardShock study

J 2021

Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study

KATAJA, Anu, Tuukka TARVASMÄKI, Johan LASSUS, Alessandro SIONIS, Alexandre MEBAZAA et. al.

Základní údaje

Originální název

Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study

Autoři

KATAJA, Anu (246 Finsko, garant), Tuukka TARVASMÄKI (246 Finsko), Johan LASSUS (246 Finsko), Alessandro SIONIS (724 Španělsko), Alexandre MEBAZAA (250 Francie), Kari PULKKI (246 Finsko), Marek BANASZEWSKI (616 Polsko), Valentina CARUBELLI (380 Itálie), Mari HONGISTO (246 Finsko), Ewa JANKOWSKA (616 Polsko), Raija JURKKO (246 Finsko), Toni JÄNTTI (246 Finsko), Monika KASZTURA (616 Polsko), John PARISSIS (300 Řecko), Tuija SABELL (246 Finsko), Jose SILVA-CARDOSO (620 Portugalsko), Jindřich ŠPINAR (203 Česká republika, domácí), Heli TOLPPANEN (246 Finsko) a Veli-Pekka HARJOLA (246 Finsko)

Vydání

International Journal of Cardiology, Clare, Elsevier, 2021, 0167-5273

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.039

Kód RIV

RIV/00216224:14110/21:00120857

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijcard.2020.08.069

UT WoS

000612679700043

Klíčová slova anglicky

Cardiogenic shock; Inflammation; Procalcitonin; Interleukin 6; C-reactive protein

Štítky

14110115, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 6. 2021 11:45, Mgr. Tereza Miškechová

Anotace

V originále

Background Inflammatory responses play an important role in the pathophysiology of cardiogenic shock (CS). The aim of this study was to investigate the kinetics of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in CS and to assess their relation to clinical presentation, other biochemical variables, and prognosis. Methods Levels of PCT, CRP and IL-6 were analyzed in serial plasma samples (0−120 h) from 183 patients in the CardShock study. The study population was dichotomized by PCT max ≥ and < 0.5 μg/L, and IL-6 and CRP max above/below median. Results PCT peaked already at 24 h [median PCT max 0.71 μg/L (IQR 0.24–3.4)], whereas CRP peaked later between 48 and 72 h [median CRP max 137 mg/L (59–247)]. PCT levels were significantly higher among non-survivors compared with survivors from 12 h on, as were CRP levels from 24 h on ( p < 0.001). PCT max ≥ 0.5 μg/L (60% of patients) was associated with clinical signs of systemic hypoperfusion, cardiac and renal dysfunction, acidosis, and higher levels of blood lactate, IL-6, growth-differentiation factor 15 (GDF-15), and CRP max. Similarly, IL-6 > median was associated with clinical signs and biochemical findings of systemic hypoperfusion. PCT max ≥ 0.5 μg/L and IL-6 > median were associated with increased 90-day mortality (50% vs. 30% and 57% vs. 22%, respectively; p < 0.01 for both), while CRP max showed no prognostic significance. The association of inflammatory markers with clinical infections was modest. Conclusions Inflammatory markers are highly related to signs of systemic hypoperfusion in CS. Moreover, high PCT and IL-6 levels are associated with poor prognosis.

Citovat

KATAJA, Anu, Tuukka TARVASMÄKI, Johan LASSUS, Alessandro SIONIS, Alexandre MEBAZAA, Kari PULKKI, Marek BANASZEWSKI, Valentina CARUBELLI, Mari HONGISTO, Ewa JANKOWSKA, Raija JURKKO, Toni JÄNTTI, Monika KASZTURA, John PARISSIS, Tuija SABELL, Jose SILVA-CARDOSO, Jindřich ŠPINAR, Heli TOLPPANEN a Veli-Pekka HARJOLA. Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study. International Journal of Cardiology. Clare: Elsevier, 2021, roč. 322, JAN 2021, s. 191-196. ISSN 0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2020.08.069.

@article{1707000,
   author = {Kataja, Anu and Tarvasmäki, Tuukka and Lassus, Johan and Sionis, Alessandro and Mebazaa, Alexandre and Pulkki, Kari and Banaszewski, Marek and Carubelli, Valentina and Hongisto, Mari and Jankowska, Ewa and Jurkko, Raija and Jäntti, Toni and Kasztura, Monika and Parissis, John and Sabell, Tuija and SilvaandCardoso, Jose and Špinar, Jindřich and Tolppanen, Heli and Harjola, VeliandPekka},
   article_location = {Clare},
   article_number = {JAN 2021},
   doi = {http://dx.doi.org/10.1016/j.ijcard.2020.08.069},
   keywords = {Cardiogenic shock; Inflammation; Procalcitonin; Interleukin 6; C-reactive protein},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study},
   url = {https://www.internationaljournalofcardiology.com/article/S0167-5273(20)33652-4/abstract#%20},
   volume = {322},
   year = {2021}
}

TY  - JOUR
ID  - 1707000
AU  - Kataja, Anu - Tarvasmäki, Tuukka - Lassus, Johan - Sionis, Alessandro - Mebazaa, Alexandre - Pulkki, Kari - Banaszewski, Marek - Carubelli, Valentina - Hongisto, Mari - Jankowska, Ewa - Jurkko, Raija - Jäntti, Toni - Kasztura, Monika - Parissis, John - Sabell, Tuija - Silva-Cardoso, Jose - Špinar, Jindřich - Tolppanen, Heli - Harjola, Veli-Pekka
PY  - 2021
TI  - Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study
JF  - International Journal of Cardiology
VL  - 322
IS  - JAN 2021
SP  - 191-196
EP  - 191-196
PB  - Elsevier
SN  - 01675273
KW  - Cardiogenic shock
KW  - Inflammation
KW  - Procalcitonin
KW  - Interleukin 6
KW  - C-reactive protein
UR  - https://www.internationaljournalofcardiology.com/article/S0167-5273(20)33652-4/abstract#%20
L2  - https://www.internationaljournalofcardiology.com/article/S0167-5273(20)33652-4/abstract#%20
N2  - Background Inflammatory responses play an important role in the pathophysiology of cardiogenic shock (CS). The aim of this study was to investigate the kinetics of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in CS and to assess their relation to clinical presentation, other biochemical variables, and prognosis. Methods Levels of PCT, CRP and IL-6 were analyzed in serial plasma samples (0−120 h) from 183 patients in the CardShock study. The study population was dichotomized by PCT max ≥ and < 0.5 μg/L, and IL-6 and CRP max above/below median. Results PCT peaked already at 24 h [median PCT max 0.71 μg/L (IQR 0.24–3.4)], whereas CRP peaked later between 48 and 72 h [median CRP max 137 mg/L (59–247)]. PCT levels were significantly higher among non-survivors compared with survivors from 12 h on, as were CRP levels from 24 h on ( p < 0.001). PCT max ≥ 0.5 μg/L (60% of patients) was associated with clinical signs of systemic hypoperfusion, cardiac and renal dysfunction, acidosis, and higher levels of blood lactate, IL-6, growth-differentiation factor 15 (GDF-15), and CRP max. Similarly, IL-6 > median was associated with clinical signs and biochemical findings of systemic hypoperfusion. PCT max ≥ 0.5 μg/L and IL-6 > median were associated with increased 90-day mortality (50% vs. 30% and 57% vs. 22%, respectively; p < 0.01 for both), while CRP max showed no prognostic significance. The association of inflammatory markers with clinical infections was modest. Conclusions Inflammatory markers are highly related to signs of systemic hypoperfusion in CS. Moreover, high PCT and IL-6 levels are associated with poor prognosis.
ER  -

KATAJA, Anu, Tuukka TARVASMÄKI, Johan LASSUS, Alessandro SIONIS, Alexandre MEBAZAA, Kari PULKKI, Marek BANASZEWSKI, Valentina CARUBELLI, Mari HONGISTO, Ewa JANKOWSKA, Raija JURKKO, Toni JÄNTTI, Monika KASZTURA, John PARISSIS, Tuija SABELL, Jose SILVA-CARDOSO, Jindřich ŠPINAR, Heli TOLPPANEN a Veli-Pekka HARJOLA. Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study. \textit{International Journal of Cardiology}. Clare: Elsevier, 2021, roč.~322, JAN 2021, s.~191-196. ISSN~0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2020.08.069.

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