Composition and Function of Telomerase-A Polymerase Associated
with the Origin of Eukaryotes

J 2020

Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes

PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra a Jiří FAJKUS

Základní údaje

Originální název

Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes

Autoři

PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra (203 Česká republika, domácí) a Jiří FAJKUS (203 Česká republika, garant, domácí)

Vydání

Biomolecules, Basel, MDPI, 2020, 2218-273X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10611 Plant sciences, botany

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.879

Kód RIV

RIV/00216224:14740/20:00114559

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3390/biom10101425

UT WoS

000584201900001

Klíčová slova anglicky

telomerase; evolution; telomerase RNA (TR); telomerase reverse transcriptase (TERT); plant TERT; plant TR

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 6. 2022 11:24, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

The canonical DNA polymerases involved in the replication of the genome are unable to fully replicate the physical ends of linear chromosomes, called telomeres. Chromosomal termini thus become shortened in each cell cycle. The maintenance of telomeres requires telomerase—a specific RNA-dependent DNA polymerase enzyme complex that carries its own RNA template and adds telomeric repeats to the ends of chromosomes using a reverse transcription mechanism. Both core subunits of telomerase—its catalytic telomerase reverse transcriptase (TERT) subunit and telomerase RNA (TR) component—were identified in quick succession in Tetrahymena more than 30 years ago. Since then, both telomerase subunits have been described in various organisms including yeasts, mammals, birds, reptiles and fish. Despite the fact that telomerase activity in plants was described 25 years ago and the TERT subunit four years later, a genuine plant TR has only recently been identified by our group. In this review, we focus on the structure, composition and function of telomerases. In addition, we discuss the origin and phylogenetic divergence of this unique RNA-dependent DNA polymerase as a witness of early eukaryotic evolution. Specifically, we discuss the latest information regarding the recently discovered TR component in plants, its conservation and its structural features.

Návaznosti

GX20-01331X, projekt VaV

Název: Biogeneze a evoluce telomerázy u rostlin

Investor: Grantová agentura ČR, Biogenesis and evolution of telomerase in plants

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra a Jiří FAJKUS. Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes. Biomolecules. Basel: MDPI, 2020, roč. 10, č. 10, s. 1-24. ISSN 2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom10101425.

@article{1707156,
   author = {Procházková Schrumpfová, Petra and Fajkus, Jiří},
   article_location = {Basel},
   article_number = {10},
   doi = {http://dx.doi.org/10.3390/biom10101425},
   keywords = {telomerase; evolution; telomerase RNA (TR); telomerase reverse transcriptase (TERT); plant TERT; plant TR},
   language = {eng},
   issn = {2218-273X},
   journal = {Biomolecules},
   title = {Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes},
   url = {http://www.mdpi.com/journal/biomolecules},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1707156
AU  - Procházková Schrumpfová, Petra - Fajkus, Jiří
PY  - 2020
TI  - Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes
JF  - Biomolecules
VL  - 10
IS  - 10
SP  - 1-24
EP  - 1-24
PB  - MDPI
SN  - 2218273X
KW  - telomerase
KW  - evolution
KW  - telomerase RNA (TR)
KW  - telomerase reverse transcriptase (TERT)
KW  - plant TERT
KW  - plant TR
UR  - http://www.mdpi.com/journal/biomolecules
L2  - http://www.mdpi.com/journal/biomolecules
N2  - The canonical DNA polymerases involved in the replication of the genome are unable to fully replicate the physical ends of linear chromosomes, called telomeres. Chromosomal termini thus become shortened in each cell cycle. The maintenance of telomeres requires telomerase—a specific RNA-dependent DNA polymerase enzyme complex that carries its own RNA template and adds telomeric repeats to the ends of chromosomes using a reverse transcription mechanism. Both core subunits of telomerase—its catalytic telomerase reverse transcriptase (TERT) subunit and telomerase RNA (TR) component—were identified in quick succession in Tetrahymena more than 30 years ago. Since then, both telomerase subunits have been described in various organisms including yeasts, mammals, birds, reptiles and fish. Despite the fact that telomerase activity in plants was described 25 years ago and the TERT subunit four years later, a genuine plant TR has only recently been identified by our group. In this review, we focus on the structure, composition and function of telomerases. In addition, we discuss the origin and phylogenetic divergence of this unique RNA-dependent DNA polymerase as a witness of early eukaryotic evolution. Specifically, we discuss the latest information regarding the recently discovered TR component in plants, its conservation and its structural features.
ER  -

PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra a Jiří FAJKUS. Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes. \textit{Biomolecules}. Basel: MDPI, 2020, roč.~10, č.~10, s.~1-24. ISSN~2218-273X. Dostupné z: https://dx.doi.org/10.3390/biom10101425.

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