Crosstalk between the transcriptional regulation of dopamine D2
and cannabinoid CB1 receptors in perinatal
delta9-tetrahydrocannabinol occurs in schizophrenia: analyses
in patients and in animal model of the disease

J 2021

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR et. al.

Základní údaje

Originální název

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

Název česky

Vztah mezi regulací trankripce D2 a CB1 receptorů v perimatálním delta9-tetrahydrocannabinolovém modelu a u pacientů se schizofrenií

Autoři

DI BARTOLOMEO, Martina (380 Itálie), Tibor ŠTARK (703 Slovensko, domácí), Maurel ORIANA MARIA (380 Itálie), Fabio Arturo IANNOTTI (380 Itálie), Martin KUCHAR (203 Česká republika), Jana RUDÁ (203 Česká republika, domácí), Fabiana PISCITELLI (380 Itálie), Samuele LAUDANI (380 Itálie), Vladimír PEKAŘÍK (203 Česká republika, domácí), Salvatore SALOMONE (124 Kanada), Beatrice AROSIO (380 Itálie), Raphael MECHOULAM, Mauro MACCARRONE (380 Itálie), Filippo DRAGO (380 Itálie), Carsten WOTJAK (276 Německo), Vincenzo DI MARZO (380 Itálie), Matteo VISMARA (380 Itálie), Bernardo DELL'OSSO (380 Itálie), Claudio D'ADDARIO (380 Itálie) a Vincenzo MICALE (380 Itálie, garant)

Vydání

PHARMACOLOGICAL RESEARCH, London, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, 1043-6618

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.334

Kód RIV

RIV/00216224:14110/21:00120866

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.phrs.2020.105357

UT WoS

000615153300017

Klíčová slova anglicky

Schizophrenia; THC; Cannabinoid CB1 receptor; Dopamine D2 Receptor; Cannabidiol; DNA methylation; Epigenetics

Štítky

14110515, 14110516, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 6. 2021 08:01, Mgr. Tereza Miškechová

Anotace

V originále

Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.

Návaznosti

MUNI/A/1292/2019, interní kód MU

Název: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masarykova univerzita, Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR, Jana RUDÁ, Fabiana PISCITELLI, Samuele LAUDANI, Vladimír PEKAŘÍK, Salvatore SALOMONE, Beatrice AROSIO, Raphael MECHOULAM, Mauro MACCARRONE, Filippo DRAGO, Carsten WOTJAK, Vincenzo DI MARZO, Matteo VISMARA, Bernardo DELL'OSSO, Claudio D'ADDARIO a Vincenzo MICALE. Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease. PHARMACOLOGICAL RESEARCH. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, roč. 164, FEB 2021, s. 105357-105366. ISSN 1043-6618. Dostupné z: https://dx.doi.org/10.1016/j.phrs.2020.105357.

@article{1709396,
   author = {Di Bartolomeo, Martina and Štark, Tibor and Oriana Maria, Maurel and Iannotti, Fabio Arturo and Kuchar, Martin and Rudá, Jana and Piscitelli, Fabiana and Laudani, Samuele and Pekařík, Vladimír and Salomone, Salvatore and Arosio, Beatrice and Mechoulam, Raphael and Maccarrone, Mauro and Drago, Filippo and Wotjak, Carsten and Di Marzo, Vincenzo and Vismara, Matteo and Dell'Osso, Bernardo and D'Addario, Claudio and Micale, Vincenzo},
   article_location = {London},
   article_number = {FEB 2021},
   doi = {http://dx.doi.org/10.1016/j.phrs.2020.105357},
   keywords = {Schizophrenia; THC; Cannabinoid CB1 receptor; Dopamine D2 Receptor; Cannabidiol; DNA methylation; Epigenetics},
   language = {eng},
   issn = {1043-6618},
   journal = {PHARMACOLOGICAL RESEARCH},
   title = {Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease},
   url = {https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub},
   volume = {164},
   year = {2021}
}

TY  - JOUR
ID  - 1709396
AU  - Di Bartolomeo, Martina - Štark, Tibor - Oriana Maria, Maurel - Iannotti, Fabio Arturo - Kuchar, Martin - Rudá, Jana - Piscitelli, Fabiana - Laudani, Samuele - Pekařík, Vladimír - Salomone, Salvatore - Arosio, Beatrice - Mechoulam, Raphael - Maccarrone, Mauro - Drago, Filippo - Wotjak, Carsten - Di Marzo, Vincenzo - Vismara, Matteo - Dell'Osso, Bernardo - D'Addario, Claudio - Micale, Vincenzo
PY  - 2021
TI  - Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease
JF  - PHARMACOLOGICAL RESEARCH
VL  - 164
IS  - FEB 2021
SP  - 105357
EP  - 105357
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10436618
KW  - Schizophrenia
KW  - THC
KW  - Cannabinoid CB1 receptor
KW  - Dopamine D2 Receptor
KW  - Cannabidiol
KW  - DNA methylation
KW  - Epigenetics
UR  - https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub
N2  - Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.
ER  -

DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR, Jana RUDÁ, Fabiana PISCITELLI, Samuele LAUDANI, Vladimír PEKAŘÍK, Salvatore SALOMONE, Beatrice AROSIO, Raphael MECHOULAM, Mauro MACCARRONE, Filippo DRAGO, Carsten WOTJAK, Vincenzo DI MARZO, Matteo VISMARA, Bernardo DELL'OSSO, Claudio D'ADDARIO a Vincenzo MICALE. Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease. \textit{PHARMACOLOGICAL RESEARCH}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, roč.~164, FEB 2021, s.~105357-105366. ISSN~1043-6618. Dostupné z: https://dx.doi.org/10.1016/j.phrs.2020.105357.

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