Další formáty:
BibTeX
LaTeX
RIS
@article{1710016,
author = {Zeni, Pedro and Mráz, Marek},
article_location = {Philadelphia},
article_number = {5},
doi = {http://dx.doi.org/10.1080/15476286.2020.1838783},
keywords = {LncRNAs; Adaptive immunity; T cell; B cell; Lymphocyte development; B; T cell activation; T cell polarization; Autoimmune diseases; Leukaemia; Lymphoma},
language = {eng},
issn = {1547-6286},
journal = {RNA Biology},
title = {LncRNAs in adaptive immunity: role in physiological and pathological conditions},
url = {https://doi.org/10.1080/15476286.2020.1838783},
volume = {18},
year = {2021}
}
TY - JOUR
ID - 1710016
AU - Zeni, Pedro - Mráz, Marek
PY - 2021
TI - LncRNAs in adaptive immunity: role in physiological and pathological conditions
JF - RNA Biology
VL - 18
IS - 5
SP - 619-632
EP - 619-632
PB - Taylor & Francis Inc
SN - 15476286
KW - LncRNAs
KW - Adaptive immunity
KW - T cell
KW - B cell
KW - Lymphocyte development
KW - B
KW - T cell activation
KW - T cell polarization
KW - Autoimmune diseases
KW - Leukaemia
KW - Lymphoma
UR - https://doi.org/10.1080/15476286.2020.1838783
L2 - https://doi.org/10.1080/15476286.2020.1838783
N2 - The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NF kappa B, MYC, interferon and TCR/BCR signalling (NRON, NKILA, BCALM, GAS5, PVT1), and cell effector functions (IFNG-AS1, TH2-LCR). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration.
ER -
ZENI, Pedro a Marek MRÁZ. LncRNAs in adaptive immunity: role in physiological and pathological conditions. \textit{RNA Biology}. Philadelphia: Taylor \&{} Francis Inc, 2021, roč.~18, č.~5, s.~619-632. ISSN~1547-6286. Dostupné z: https://dx.doi.org/10.1080/15476286.2020.1838783.
|
