LncRNAs in adaptive immunity: role in physiological and
pathological conditions

J 2021

LncRNAs in adaptive immunity: role in physiological and pathological conditions

ZENI, Pedro a Marek MRÁZ

Základní údaje

Originální název

LncRNAs in adaptive immunity: role in physiological and pathological conditions

Autoři

ZENI, Pedro (76 Brazílie, domácí) a Marek MRÁZ (203 Česká republika, garant, domácí)

Vydání

RNA Biology, Philadelphia, Taylor & Francis Inc, 2021, 1547-6286

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.766

Kód RIV

RIV/00216224:14740/21:00120867

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1080/15476286.2020.1838783

UT WoS

000587536300001

Klíčová slova anglicky

LncRNAs; Adaptive immunity; T cell; B cell; Lymphocyte development; B; T cell activation; T cell polarization; Autoimmune diseases; Leukaemia; Lymphoma

Štítky

14110212, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2022 14:09, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NF kappa B, MYC, interferon and TCR/BCR signalling (NRON, NKILA, BCALM, GAS5, PVT1), and cell effector functions (IFNG-AS1, TH2-LCR). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration.

Citovat

ZENI, Pedro a Marek MRÁZ. LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA Biology. Philadelphia: Taylor & Francis Inc, 2021, roč. 18, č. 5, s. 619-632. ISSN 1547-6286. Dostupné z: https://dx.doi.org/10.1080/15476286.2020.1838783.

@article{1710016,
   author = {Zeni, Pedro and Mráz, Marek},
   article_location = {Philadelphia},
   article_number = {5},
   doi = {http://dx.doi.org/10.1080/15476286.2020.1838783},
   keywords = {LncRNAs; Adaptive immunity; T cell; B cell; Lymphocyte development; B; T cell activation; T cell polarization; Autoimmune diseases; Leukaemia; Lymphoma},
   language = {eng},
   issn = {1547-6286},
   journal = {RNA Biology},
   title = {LncRNAs in adaptive immunity: role in physiological and pathological conditions},
   url = {https://doi.org/10.1080/15476286.2020.1838783},
   volume = {18},
   year = {2021}
}

TY  - JOUR
ID  - 1710016
AU  - Zeni, Pedro - Mráz, Marek
PY  - 2021
TI  - LncRNAs in adaptive immunity: role in physiological and pathological conditions
JF  - RNA Biology
VL  - 18
IS  - 5
SP  - 619-632
EP  - 619-632
PB  - Taylor & Francis Inc
SN  - 15476286
KW  - LncRNAs
KW  - Adaptive immunity
KW  - T cell
KW  - B cell
KW  - Lymphocyte development
KW  - B
KW  - T cell activation
KW  - T cell polarization
KW  - Autoimmune diseases
KW  - Leukaemia
KW  - Lymphoma
UR  - https://doi.org/10.1080/15476286.2020.1838783
L2  - https://doi.org/10.1080/15476286.2020.1838783
N2  - The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NF kappa B, MYC, interferon and TCR/BCR signalling (NRON, NKILA, BCALM, GAS5, PVT1), and cell effector functions (IFNG-AS1, TH2-LCR). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration.
ER  -

ZENI, Pedro a Marek MRÁZ. LncRNAs in adaptive immunity: role in physiological and pathological conditions. \textit{RNA Biology}. Philadelphia: Taylor \&{} Francis Inc, 2021, roč.~18, č.~5, s.~619-632. ISSN~1547-6286. Dostupné z: https://dx.doi.org/10.1080/15476286.2020.1838783.

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