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@article{1710016, author = {Zeni, Pedro and Mráz, Marek}, article_location = {Philadelphia}, article_number = {5}, doi = {http://dx.doi.org/10.1080/15476286.2020.1838783}, keywords = {LncRNAs; Adaptive immunity; T cell; B cell; Lymphocyte development; B; T cell activation; T cell polarization; Autoimmune diseases; Leukaemia; Lymphoma}, language = {eng}, issn = {1547-6286}, journal = {RNA Biology}, title = {LncRNAs in adaptive immunity: role in physiological and pathological conditions}, url = {https://doi.org/10.1080/15476286.2020.1838783}, volume = {18}, year = {2021} }
TY - JOUR ID - 1710016 AU - Zeni, Pedro - Mráz, Marek PY - 2021 TI - LncRNAs in adaptive immunity: role in physiological and pathological conditions JF - RNA Biology VL - 18 IS - 5 SP - 619-632 EP - 619-632 PB - Taylor & Francis Inc SN - 15476286 KW - LncRNAs KW - Adaptive immunity KW - T cell KW - B cell KW - Lymphocyte development KW - B KW - T cell activation KW - T cell polarization KW - Autoimmune diseases KW - Leukaemia KW - Lymphoma UR - https://doi.org/10.1080/15476286.2020.1838783 L2 - https://doi.org/10.1080/15476286.2020.1838783 N2 - The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NF kappa B, MYC, interferon and TCR/BCR signalling (NRON, NKILA, BCALM, GAS5, PVT1), and cell effector functions (IFNG-AS1, TH2-LCR). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration. ER -
ZENI, Pedro a Marek MRÁZ. LncRNAs in adaptive immunity: role in physiological and pathological conditions. \textit{RNA Biology}. Philadelphia: Taylor \&{} Francis Inc, 2021, roč.~18, č.~5, s.~619-632. ISSN~1547-6286. Dostupné z: https://dx.doi.org/10.1080/15476286.2020.1838783.
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