LncRNAs in adaptive immunity: role in physiological and pathological conditions

ZENI, Pedro and Marek MRÁZ. LncRNAs in adaptive immunity: role in physiological and pathological conditions. RNA Biology. Philadelphia: Taylor & Francis Inc, 2021, vol. 18, No 5, p. 619-632. ISSN 1547-6286. Available from: https://dx.doi.org/10.1080/15476286.2020.1838783.

Basic information

• Original name: LncRNAs in adaptive immunity: role in physiological and pathological conditions
• Authors: ZENI, Pedro (76 Brazil, belonging to the institution) and Marek MRÁZ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: RNA Biology, Philadelphia, Taylor & Francis Inc, 2021, 1547-6286.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10601 Cell biology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.766
• RIV identification code: RIV/00216224:14740/21:00120867
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1080/15476286.2020.1838783
• UT WoS: 000587536300001
• Keywords in English: LncRNAs; Adaptive immunity; T cell; B cell; Lymphocyte development; B; T cell activation; T cell polarization; Autoimmune diseases; Leukaemia; Lymphoma
• Tags: 14110212, podil, rivok
• Tags: International impact, Reviewed

Abstract

The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NF kappa B, MYC, interferon and TCR/BCR signalling (NRON, NKILA, BCALM, GAS5, PVT1), and cell effector functions (IFNG-AS1, TH2-LCR). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration.