CHALLENGES IN STRUCTURAL AND INTERACTION PROPERTIES OF INTRINSICALLY DISORDERED PROTEINS

HRITZ, Jozef. CHALLENGES IN STRUCTURAL AND INTERACTION PROPERTIES OF INTRINSICALLY DISORDERED PROTEINS. In XX. Workshop of Biophysical Chemists and Electrochemists. 2020. ISBN 978-80-210-9655-4.

Basic information

• Original name: CHALLENGES IN STRUCTURAL AND INTERACTION PROPERTIES OF INTRINSICALLY DISORDERED PROTEINS
• Authors: HRITZ, Jozef.
• Edition: XX. Workshop of Biophysical Chemists and Electrochemists, 2020.

Other information

• Original language: English
• Type of outcome: Requested lectures
• Field of Study: 10608 Biochemistry and molecular biology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• ISBN: 978-80-210-9655-4
• Keywords in English: Intrinsically disordered proteins

Abstract

Intrinsically disordered proteins (IDPs) lack a stable 3D structure. Their significance is increasingly recognized after proteomic analysis showing that about one tenth of all eukaryotic proteins are IDPs and more of one third contain considerably long intrinsically disordered protein regions (IDPRs). The missing stable 3D structure prevents using crystallographic and cryoEM methodologies.

Links

• LM2015085, research and development project: Name: CERIT Scientific Cloud (Acronym: CERIT-SC)

Investor: Ministry of Education, Youth and Sports of the CR, CERIT Scientific Cloud

• LM2018127, research and development project: Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

• LTAUSA18168, research and development project: Name: Selektivní NMR značení jako nástroj pro charakterizaci proteinových komplexů zapojených do neurodegenerativních onemocnění

Investor: Ministry of Education, Youth and Sports of the CR, Selective NMR labelling as a tool for characterization of protein complexes involved in neurodegenerative diseases., INTER-ACTION