Needles in a haystack: Extremely rare invasive fungal
infections reported in FungiScope (R)-Global Registry for
Emerging Fungal Infections

J 2020

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ et. al.

Základní údaje

Originální název

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections

Autoři

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ, Zdeněk RÁČIL (203 Česká republika, domácí), Sharon C. A. CHEN, Nikolai KLIMKO, Guillaume DESOUBEAUX, George R. THOMPSON, Miguel-Angel BENITEZ-PENUELA, Jose-Yesid RODRIGUEZ, Donald C. SHEPPARD, Martin HOENIGL, Yohann LE GOVIC, Hamid BADALI, John W. BADDLEY, Jagdish CHANDER, Paul R. INGRAM, Diana L. PAKSTIS, Sibylle C. MELLINGHOFF, Serkan ATICI, Simone CESARO, Arunaloke CHAKRABARTI, Damien DUPONT, Gloria M. GONZALEZ, Lorant HATVANI, Raoul HERBRECHT, Galina KLYASOVA, Cornelia LASS-FLORL, Mihai MARES, Kathleen MULLANE, Donald C. VINH, Hilmar WISPLINGHOFF, Michaela LACKNER, Oliver A. CORNELY a Danila SEIDEL

Vydání

The Journal of infection, London, Academic Press, 2020, 0163-4453

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.072

Kód RIV

RIV/00216224:14110/20:00117464

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jinf.2020.08.015

UT WoS

000586323400017

Klíčová slova anglicky

Rare; Invasive fungal infections; Registry; Mold; Yeast

Štítky

14110212, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 12. 2020 09:26, Mgr. Tereza Miškechová

Anotace

V originále

Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Citovat

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ, Zdeněk RÁČIL, Sharon C. A. CHEN, Nikolai KLIMKO, Guillaume DESOUBEAUX, George R. THOMPSON, Miguel-Angel BENITEZ-PENUELA, Jose-Yesid RODRIGUEZ, Donald C. SHEPPARD, Martin HOENIGL, Yohann LE GOVIC, Hamid BADALI, John W. BADDLEY, Jagdish CHANDER, Paul R. INGRAM, Diana L. PAKSTIS, Sibylle C. MELLINGHOFF, Serkan ATICI, Simone CESARO, Arunaloke CHAKRABARTI, Damien DUPONT, Gloria M. GONZALEZ, Lorant HATVANI, Raoul HERBRECHT, Galina KLYASOVA, Cornelia LASS-FLORL, Mihai MARES, Kathleen MULLANE, Donald C. VINH, Hilmar WISPLINGHOFF, Michaela LACKNER, Oliver A. CORNELY a Danila SEIDEL. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections. The Journal of infection. London: Academic Press, 2020, roč. 81, č. 5, s. 802-815. ISSN 0163-4453. Dostupné z: https://dx.doi.org/10.1016/j.jinf.2020.08.015.

@article{1713497,
   author = {SalmantonandGarcia, Jon and Koehler, Philipp and Kindo, Anupma and FalcesandRomero, Iker and GarciaandRodriguez, Julio and Ráčil, Zdeněk and Chen, Sharon C. A. and Klimko, Nikolai and Desoubeaux, Guillaume and Thompson, George R. and BenitezandPenuela, MiguelandAngel and Rodriguez, JoseandYesid and Sheppard, Donald C. and Hoenigl, Martin and Le Govic, Yohann and Badali, Hamid and Baddley, John W. and Chander, Jagdish and Ingram, Paul R. and Pakstis, Diana L. and Mellinghoff, Sibylle C. and Atici, Serkan and Cesaro, Simone and Chakrabarti, Arunaloke and Dupont, Damien and Gonzalez, Gloria M. and Hatvani, Lorant and Herbrecht, Raoul and Klyasova, Galina and LassandFlorl, Cornelia and Mares, Mihai and Mullane, Kathleen and Vinh, Donald C. and Wisplinghoff, Hilmar and Lackner, Michaela and Cornely, Oliver A. and Seidel, Danila},
   article_location = {London},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.jinf.2020.08.015},
   keywords = {Rare; Invasive fungal infections; Registry; Mold; Yeast},
   language = {eng},
   issn = {0163-4453},
   journal = {The Journal of infection},
   title = {Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections},
   url = {https://www.journalofinfection.com/article/S0163-4453(20)30549-1/fulltext},
   volume = {81},
   year = {2020}
}

TY  - JOUR
ID  - 1713497
AU  - Salmanton-Garcia, Jon - Koehler, Philipp - Kindo, Anupma - Falces-Romero, Iker - Garcia-Rodriguez, Julio - Ráčil, Zdeněk - Chen, Sharon C. A. - Klimko, Nikolai - Desoubeaux, Guillaume - Thompson, George R. - Benitez-Penuela, Miguel-Angel - Rodriguez, Jose-Yesid - Sheppard, Donald C. - Hoenigl, Martin - Le Govic, Yohann - Badali, Hamid - Baddley, John W. - Chander, Jagdish - Ingram, Paul R. - Pakstis, Diana L. - Mellinghoff, Sibylle C. - Atici, Serkan - Cesaro, Simone - Chakrabarti, Arunaloke - Dupont, Damien - Gonzalez, Gloria M. - Hatvani, Lorant - Herbrecht, Raoul - Klyasova, Galina - Lass-Florl, Cornelia - Mares, Mihai - Mullane, Kathleen - Vinh, Donald C. - Wisplinghoff, Hilmar - Lackner, Michaela - Cornely, Oliver A. - Seidel, Danila
PY  - 2020
TI  - Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections
JF  - The Journal of infection
VL  - 81
IS  - 5
SP  - 802-815
EP  - 802-815
PB  - Academic Press
SN  - 01634453
KW  - Rare
KW  - Invasive fungal infections
KW  - Registry
KW  - Mold
KW  - Yeast
UR  - https://www.journalofinfection.com/article/S0163-4453(20)30549-1/fulltext
L2  - https://www.journalofinfection.com/article/S0163-4453(20)30549-1/fulltext
N2  - Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
ER  -

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ, Zdeněk RÁČIL, Sharon C. A. CHEN, Nikolai KLIMKO, Guillaume DESOUBEAUX, George R. THOMPSON, Miguel-Angel BENITEZ-PENUELA, Jose-Yesid RODRIGUEZ, Donald C. SHEPPARD, Martin HOENIGL, Yohann LE GOVIC, Hamid BADALI, John W. BADDLEY, Jagdish CHANDER, Paul R. INGRAM, Diana L. PAKSTIS, Sibylle C. MELLINGHOFF, Serkan ATICI, Simone CESARO, Arunaloke CHAKRABARTI, Damien DUPONT, Gloria M. GONZALEZ, Lorant HATVANI, Raoul HERBRECHT, Galina KLYASOVA, Cornelia LASS-FLORL, Mihai MARES, Kathleen MULLANE, Donald C. VINH, Hilmar WISPLINGHOFF, Michaela LACKNER, Oliver A. CORNELY a Danila SEIDEL. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections. \textit{The Journal of infection}. London: Academic Press, 2020, roč.~81, č.~5, s.~802-815. ISSN~0163-4453. Dostupné z: https://dx.doi.org/10.1016/j.jinf.2020.08.015.

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