Coordinated labio-lingual asymmetries in dental and bone
development create a symmetrical acrodont dentition

J 2020

Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition

KAVKOVÁ, M., Marie ŠULCOVÁ, Jana DUMKOVÁ, O. ZAHRADNÍČEK, J. KAISER et. al.

Základní údaje

Originální název

Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition

Autoři

KAVKOVÁ, M., Marie ŠULCOVÁ (203 Česká republika, domácí), Jana DUMKOVÁ (203 Česká republika, domácí), O. ZAHRADNÍČEK, J. KAISER, A. S. TUCKER, T. ZIKMUND a Marcela BUCHTOVÁ (203 Česká republika, garant, domácí)

Vydání

Scientific Reports, Berlin, Nature Research, 2020, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.379

Kód RIV

RIV/00216224:14310/20:00114615

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/s41598-020-78939-2

UT WoS

000603657800006

Klíčová slova anglicky

Body patterning; Bone development

Štítky

14110517, CF CELLIM, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2023 12:19, Mgr. Marie Šípková, DiS.

Anotace

V originále

Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade.

Návaznosti

GA17-14886S, projekt VaV

Název: Molekulární a buněčná dynamika rozhraní zubu a kosti u modelových druhů s akrodontní, pleurodontní a tekodontní denticí

Investor: Grantová agentura ČR, Molekulární a buněčná dynamika rozhraní zubu a kosti u modelových druhů s akrodontní, pleurodontní a tekodontní denticí

LM2018129, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

KAVKOVÁ, M., Marie ŠULCOVÁ, Jana DUMKOVÁ, O. ZAHRADNÍČEK, J. KAISER, A. S. TUCKER, T. ZIKMUND a Marcela BUCHTOVÁ. Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition. Scientific Reports. Berlin: Nature Research, 2020, roč. 10, č. 1, s. 1-16. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-78939-2.

@article{1717837,
   author = {Kavková, M. and Šulcová, Marie and Dumková, Jana and Zahradníček, O. and Kaiser, J. and Tucker, A. S. and Zikmund, T. and Buchtová, Marcela},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-78939-2},
   keywords = {Body patterning; Bone development},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition},
   url = {https://doi.org/10.1038/s41598-020-78939-2},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1717837
AU  - Kavková, M. - Šulcová, Marie - Dumková, Jana - Zahradníček, O. - Kaiser, J. - Tucker, A. S. - Zikmund, T. - Buchtová, Marcela
PY  - 2020
TI  - Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
JF  - Scientific Reports
VL  - 10
IS  - 1
SP  - 1-16
EP  - 1-16
PB  - Nature Research
SN  - 20452322
KW  - Body patterning
KW  - Bone development
UR  - https://doi.org/10.1038/s41598-020-78939-2
L2  - https://doi.org/10.1038/s41598-020-78939-2
N2  - Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade.
ER  -

KAVKOVÁ, M., Marie ŠULCOVÁ, Jana DUMKOVÁ, O. ZAHRADNÍČEK, J. KAISER, A. S. TUCKER, T. ZIKMUND a Marcela BUCHTOVÁ. Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition. \textit{Scientific Reports}. Berlin: Nature Research, 2020, roč.~10, č.~1, s.~1-16. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-78939-2.

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