Mammary Organoids and 3D Cell Cultures: Old Dogs with New
Tricks

J 2020

Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks

SUMBAL, Jakub, Zuzana BUDKOVÁ, Gunnhildur Asta TRAUSTADOTTIR a Zuzana KOLEDOVÁ

Základní údaje

Originální název

Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks

Autoři

SUMBAL, Jakub (203 Česká republika, domácí), Zuzana BUDKOVÁ (203 Česká republika), Gunnhildur Asta TRAUSTADOTTIR (352 Island) a Zuzana KOLEDOVÁ (703 Slovensko, garant, domácí)

Vydání

Journal of Mammary Gland Biology and Neoplasia, New York (NY, USA), SPRINGER/PLENUM PUBLISHERS, 2020, 1083-3021

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.673

Kód RIV

RIV/00216224:14110/20:00117550

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s10911-020-09468-x

UT WoS

000590496200001

Klíčová slova anglicky

3D cell culture; Breast; Co-culture; Extracellular matrix; Imaging; Microenvironment; Organoid; Screening; Stromal cells

Štítky

14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2021 08:10, Mgr. Tereza Miškechová

Anotace

V originále

3D cell culture methods have been an integral part of and an essential tool for mammary gland and breast cancer research for half a century. In fact, mammary gland researchers, who discovered and deciphered the instructive role of extracellular matrix (ECM) in mammary epithelial cell functional differentiation and morphogenesis, were the pioneers of the 3D cell culture techniques, including organoid cultures. The last decade has brought a tremendous increase in the 3D cell culture techniques, including modifications and innovations of the existing techniques, novel biomaterials and matrices, new technological approaches, and increase in 3D culture complexity, accompanied by several redefinitions of the terms "3D cell culture" and "organoid". In this review, we provide an overview of the 3D cell culture and organoid techniques used in mammary gland biology and breast cancer research. We discuss their advantages, shortcomings and current challenges, highlight the recent progress in reconstructing the complex mammary gland microenvironment in vitro and ex vivo, and identify the missing 3D cell cultures, urgently needed to aid our understanding of mammary gland development, function, physiology, and disease, including breast cancer.

Návaznosti

MUNI/A/1382/2019, interní kód MU

Název: Zdroje pro tkáňové inženýrství 10 (Akronym: TissueEng 10)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 10, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/G/1446/2018, interní kód MU

Název: Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling

Investor: Masarykova univerzita, Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling, INTERDISCIPLINARY - Mezioborové výzkumné projekty

ROZV/28/LF19/2020, interní kód MU

Název: Regulace morfogeneze epitelu mléčné žlázy pomocí mechanických sil a dynamiky signalizace

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Regulace morfogeneze epitelu mléčné žlázy pomocí mechanických sil a dynamiky signalizace, Interní rozvojové projekty

Citovat

SUMBAL, Jakub, Zuzana BUDKOVÁ, Gunnhildur Asta TRAUSTADOTTIR a Zuzana KOLEDOVÁ. Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks. Journal of Mammary Gland Biology and Neoplasia. New York (NY, USA): SPRINGER/PLENUM PUBLISHERS, 2020, roč. 25, č. 4, s. 273-288. ISSN 1083-3021. Dostupné z: https://dx.doi.org/10.1007/s10911-020-09468-x.

@article{1718816,
   author = {Sumbal, Jakub and Budková, Zuzana and Traustadottir, Gunnhildur Asta and Koledová, Zuzana},
   article_location = {New York (NY, USA)},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s10911-020-09468-x},
   keywords = {3D cell culture; Breast; Co-culture; Extracellular matrix; Imaging; Microenvironment; Organoid; Screening; Stromal cells},
   language = {eng},
   issn = {1083-3021},
   journal = {Journal of Mammary Gland Biology and Neoplasia},
   title = {Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks},
   url = {https://link.springer.com/article/10.1007%2Fs10911-020-09468-x},
   volume = {25},
   year = {2020}
}

TY  - JOUR
ID  - 1718816
AU  - Sumbal, Jakub - Budková, Zuzana - Traustadottir, Gunnhildur Asta - Koledová, Zuzana
PY  - 2020
TI  - Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks
JF  - Journal of Mammary Gland Biology and Neoplasia
VL  - 25
IS  - 4
SP  - 273-288
EP  - 273-288
PB  - SPRINGER/PLENUM PUBLISHERS
SN  - 10833021
KW  - 3D cell culture
KW  - Breast
KW  - Co-culture
KW  - Extracellular matrix
KW  - Imaging
KW  - Microenvironment
KW  - Organoid
KW  - Screening
KW  - Stromal cells
UR  - https://link.springer.com/article/10.1007%2Fs10911-020-09468-x
L2  - https://link.springer.com/article/10.1007%2Fs10911-020-09468-x
N2  - 3D cell culture methods have been an integral part of and an essential tool for mammary gland and breast cancer research for half a century. In fact, mammary gland researchers, who discovered and deciphered the instructive role of extracellular matrix (ECM) in mammary epithelial cell functional differentiation and morphogenesis, were the pioneers of the 3D cell culture techniques, including organoid cultures. The last decade has brought a tremendous increase in the 3D cell culture techniques, including modifications and innovations of the existing techniques, novel biomaterials and matrices, new technological approaches, and increase in 3D culture complexity, accompanied by several redefinitions of the terms "3D cell culture" and "organoid". In this review, we provide an overview of the 3D cell culture and organoid techniques used in mammary gland biology and breast cancer research. We discuss their advantages, shortcomings and current challenges, highlight the recent progress in reconstructing the complex mammary gland microenvironment in vitro and ex vivo, and identify the missing 3D cell cultures, urgently needed to aid our understanding of mammary gland development, function, physiology, and disease, including breast cancer.
ER  -

SUMBAL, Jakub, Zuzana BUDKOVÁ, Gunnhildur Asta TRAUSTADOTTIR a Zuzana KOLEDOVÁ. Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks. \textit{Journal of Mammary Gland Biology and Neoplasia}. New York (NY, USA): SPRINGER/PLENUM PUBLISHERS, 2020, roč.~25, č.~4, s.~273-288. ISSN~1083-3021. Dostupné z: https://dx.doi.org/10.1007/s10911-020-09468-x.

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