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@article{1720297,
author = {Strýček, Ondřej and Lamoš, Martin and Klimes, P. and Rektor, Ivan},
article_location = {SAN DIEGO},
article_number = {NOV},
doi = {http://dx.doi.org/10.1016/j.yebeh.2020.107409},
keywords = {Temporal lobe epilepsy; High-density EEG; Functional connectivity; Cognitive network},
language = {eng},
issn = {1525-5050},
journal = {EPILEPSY & BEHAVIOR},
title = {Cognitive task-related functional connectivity alterations in temporal lobe epilepsy},
url = {https://www.sciencedirect.com/science/article/pii/S1525505020305886?via%3Dihub},
volume = {112},
year = {2020}
}
TY - JOUR
ID - 1720297
AU - Strýček, Ondřej - Lamoš, Martin - Klimes, P. - Rektor, Ivan
PY - 2020
TI - Cognitive task-related functional connectivity alterations in temporal lobe epilepsy
JF - EPILEPSY & BEHAVIOR
VL - 112
IS - NOV
SP - 107409
EP - 107409
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 15255050
KW - Temporal lobe epilepsy
KW - High-density EEG
KW - Functional connectivity
KW - Cognitive network
UR - https://www.sciencedirect.com/science/article/pii/S1525505020305886?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1525505020305886?via%3Dihub
N2 - Objective: We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe. Methods: High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, possible compensatory mechanisms were investigated. Results: Significant changes were found in the EC of regions outside the epileptogenic network, particularly in the attentional network. These changes were more widespread in left TLE (LTLE). There were no significant differences in task performance (accuracy, time response) in comparison with HCs, implying that there must be some mechanism reducing the impact of connectivity changes on brain functions. When correlated with neuropsychological data, we found stronger compensatory mechanisms in right TLE (RILE). Significance: Our findings confirm the hypothesis that DIE is the more pervasive form of the disease. Even though the network alterations in TLE are severe, some mechanisms reduce the impact of epilepsy on cognitive functions; these mechanisms are more potent in RILE. We also suggest that there are maladaptive mechanisms in LTLE. (C) 2020 Elsevier Inc. All rights reserved.
ER -
STRÝČEK, Ondřej, Martin LAMOŠ, P. KLIMES a Ivan REKTOR. Cognitive task-related functional connectivity alterations in temporal lobe epilepsy. \textit{EPILEPSY \&{}amp; BEHAVIOR}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, roč.~112, NOV, s.~107409-107415. ISSN~1525-5050. Dostupné z: https://dx.doi.org/10.1016/j.yebeh.2020.107409.
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