YADAV, Deepak Kumar, Dagmar ZIGÁČKOVÁ, Maria ZLOBINA, Tomáš KLUMPLER, Christelle BEAUMONT, Monika KUBÍČKOVÁ, Štěpánka VAŇÁČOVÁ a Peter LUKAVSKY. Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition. Nucleic acids research. Oxford: Oxford University Press, 2020, roč. 48, č. 4, s. 2091-2106. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkz1163. |
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@article{1720519, author = {Yadav, Deepak Kumar and Zigáčková, Dagmar and Zlobina, Maria and Klumpler, Tomáš and Beaumont, Christelle and Kubíčková, Monika and Vaňáčová, Štěpánka and Lukavsky, Peter}, article_location = {Oxford}, article_number = {4}, doi = {http://dx.doi.org/10.1093/nar/gkz1163}, keywords = {DOUBLE-STRANDED-RNA; NMR STRUCTURE DETERMINATION; LARGE-SCALE PREPARATION; BICOID MESSENGER-RNA; SECONDARY STRUCTURES; BINDING PROTEIN; DOMAIN; PURIFICATION; NOESY; LOCALIZATION}, language = {eng}, issn = {0305-1048}, journal = {Nucleic acids research}, title = {Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition}, url = {https://watermark.silverchair.com/gkz1163.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArMwggKvBgkqhkiG9w0BBwagggKgMIICnAIBADCCApUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM93m65EaHAul9lvZ3AgEQgIICZgl4kN1MOxCY84aEvwwQEi6vjxrtsNYzBuhYRTUjwbqxdd}, volume = {48}, year = {2020} }
TY - JOUR ID - 1720519 AU - Yadav, Deepak Kumar - Zigáčková, Dagmar - Zlobina, Maria - Klumpler, Tomáš - Beaumont, Christelle - Kubíčková, Monika - Vaňáčová, Štěpánka - Lukavsky, Peter PY - 2020 TI - Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition JF - Nucleic acids research VL - 48 IS - 4 SP - 2091-2106 EP - 2091-2106 PB - Oxford University Press SN - 03051048 KW - DOUBLE-STRANDED-RNA KW - NMR STRUCTURE DETERMINATION KW - LARGE-SCALE PREPARATION KW - BICOID MESSENGER-RNA KW - SECONDARY STRUCTURES KW - BINDING PROTEIN KW - DOMAIN KW - PURIFICATION KW - NOESY KW - LOCALIZATION UR - https://watermark.silverchair.com/gkz1163.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArMwggKvBgkqhkiG9w0BBwagggKgMIICnAIBADCCApUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM93m65EaHAul9lvZ3AgEQgIICZgl4kN1MOxCY84aEvwwQEi6vjxrtsNYzBuhYRTUjwbqxdd L2 - https://watermark.silverchair.com/gkz1163.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArMwggKvBgkqhkiG9w0BBwagggKgMIICnAIBADCCApUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM93m65EaHAul9lvZ3AgEQgIICZgl4kN1MOxCY84aEvwwQEi6vjxrtsNYzBuhYRTUjwbqxdd N2 - Staufen1 (STAU1) is a dsRNA binding protein mediating mRNA transport and localization, translational control and STAU1-mediated mRNA decay (SMD). The STAU1 binding site (SBS) within human ADP-ribosylation factorl (ARF1) 3'UTR binds STAU1 and this downregulates ARF1 cytoplasmic mRNA levels by SMD. However, how STAU1 recognizes specific mRNA targets is still under debate. Our structure of the ARF1 SBS-STAU1 complex uncovers target recognition by STAU1. STAU1 dsRNA binding domain (dsRBD) 4 interacts with two pyrimidines and one purine from the minor groove side via helix alpha 1, the beta 1-beta 2 loop anchors the dsRBD at the end of the dsRNA and lysines in helix alpha 2 bind to the phosphodiester backbone from the major groove side. STAU1 dsRBD3 displays the same binding mode with specific recognition of one guanine base. Mutants disrupting minor groove recognition of ARF1 SBS affect in vitro binding and reduce SMD in vivo. Our data thus reveal how STAU1 recognizes minor groove features in dsRNA relevant for target selection. ER -
YADAV, Deepak Kumar, Dagmar ZIGÁČKOVÁ, Maria ZLOBINA, Tomáš KLUMPLER, Christelle BEAUMONT, Monika KUBÍČKOVÁ, Štěpánka VAŇÁČOVÁ a Peter LUKAVSKY. Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition. \textit{Nucleic acids research}. Oxford: Oxford University Press, 2020, roč.~48, č.~4, s.~2091-2106. ISSN~0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkz1163.
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