Correlation of survival length after pancreaticoduodenectomy
for pancreatic head adenocarcinoma depending on tumor
characteristics detected by means of computed tomography and
resection margins status

J 2020

Correlation of survival length after pancreaticoduodenectomy for pancreatic head adenocarcinoma depending on tumor characteristics detected by means of computed tomography and resection margins status

PROCHÁZKA, Vladimír, Jan HLAVSA, Lumír KUNOVSKÝ, Martina FARKAŠOVÁ, Martin POTRUSIL et. al.

Základní údaje

Originální název

Correlation of survival length after pancreaticoduodenectomy for pancreatic head adenocarcinoma depending on tumor characteristics detected by means of computed tomography and resection margins status

Autoři

PROCHÁZKA, Vladimír (203 Česká republika, domácí), Jan HLAVSA (203 Česká republika, domácí), Lumír KUNOVSKÝ (203 Česká republika, garant, domácí), Martina FARKAŠOVÁ (703 Slovensko, domácí), Martin POTRUSIL (203 Česká republika, domácí), Tomáš ANDRAŠINA (703 Slovensko, domácí), Alexandra LITAVCOVÁ (703 Slovensko, domácí), Jan MAZANEC (203 Česká republika, domácí), Jiří DOLINA (203 Česká republika, domácí), Lenka OSTŘÍŽKOVÁ (203 Česká republika, domácí), Michal EID (203 Česká republika, domácí), Petra KOVALČÍKOVÁ (203 Česká republika, domácí), Tomáš PAVLÍK (203 Česká republika, domácí) a Zdeněk KALA (203 Česká republika, domácí)

Vydání

Neoplasma, Bratislava, Slovenská akademie vied, 2020, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.575

Kód RIV

RIV/00216224:14110/20:00117597

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/neo_2020_190923N955

UT WoS

000600524900013

Klíčová slova anglicky

pancreatic cancer; pancreaticoduodenectomy; overall survival; resection margin; computed tomography; surgery

Štítky

14110212, 14110213, 14110216, 14110223, 14110230, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 1. 2021 07:37, Mgr. Tereza Miškechová

Anotace

V originále

Pancreatic carcinoma is an aggressive tumor with a grim prognosis. Accurate staging is essential for indicating surgery in patients with borderline resectable tumors. This paper examines the correlation between pre-operation characteristics of tumors found on CT, infiltration of individual resection margins as confirmed by a pathologist, and the survival of patients with resectable pancreatic head ductal adenocarcinoma. This prospective cohort study involved patients operated on for pancreatic head adenocarcinoma, which was clearly resectable based on the staging CT and intraoperative observation between 2011-2014. Only patients without postoperative complications who underwent adjuvant chemotherapy were analyzed. Seventy-nine patients were assessed, of which 16 (20.3%) had RO resection and 63 (79.7%) had R1 resection. Patients with R1 results had up to 2.7 times higher risk of death than patients with R0 resection. We found a trend towards shorter survival associated with a closer relationship of the tumor to the superior mesenteric vein/portal vein (SMV/PV) wall in the pre-operation CT examination. Patients with a tumor interface between the vein wall of up to 180 degrees circumference had up to 1.97 times higher risk of death than patients without (p=0.131). The results of our work confirmed that in our center, even surgically treated, clearly resectable pancreatic head tumors still have a high occurrence of positive surgical margins (R1 resection) and that tumors with R1 resection had statistically significantly reduced survival compared to R0 resection. A trend for shorter overall survival was found after tumor resection depending on the increasing interface between the tumor and the SMV/PV wall, but this result was not statistically significant.

Citovat

PROCHÁZKA, Vladimír, Jan HLAVSA, Lumír KUNOVSKÝ, Martina FARKAŠOVÁ, Martin POTRUSIL, Tomáš ANDRAŠINA, Alexandra LITAVCOVÁ, Jan MAZANEC, Jiří DOLINA, Lenka OSTŘÍŽKOVÁ, Michal EID, Petra KOVALČÍKOVÁ, Tomáš PAVLÍK a Zdeněk KALA. Correlation of survival length after pancreaticoduodenectomy for pancreatic head adenocarcinoma depending on tumor characteristics detected by means of computed tomography and resection margins status. Neoplasma. Bratislava: Slovenská akademie vied, 2020, roč. 67, č. 6, s. 1319-1328. ISSN 0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo_2020_190923N955.

@article{1720996,
   author = {Procházka, Vladimír and Hlavsa, Jan and Kunovský, Lumír and Farkašová, Martina and Potrusil, Martin and Andrašina, Tomáš and Litavcová, Alexandra and Mazanec, Jan and Dolina, Jiří and Ostřížková, Lenka and Eid, Michal and Kovalčíková, Petra and Pavlík, Tomáš and Kala, Zdeněk},
   article_location = {Bratislava},
   article_number = {6},
   doi = {http://dx.doi.org/10.4149/neo_2020_190923N955},
   keywords = {pancreatic cancer; pancreaticoduodenectomy; overall survival; resection margin; computed tomography; surgery},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Correlation of survival length after pancreaticoduodenectomy for pancreatic head adenocarcinoma depending on tumor characteristics detected by means of computed tomography and resection margins status},
   url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6781&category_id=85&option=com_virtuemart&vmcchk=1&Itemid=1},
   volume = {67},
   year = {2020}
}

TY  - JOUR
ID  - 1720996
AU  - Procházka, Vladimír - Hlavsa, Jan - Kunovský, Lumír - Farkašová, Martina - Potrusil, Martin - Andrašina, Tomáš - Litavcová, Alexandra - Mazanec, Jan - Dolina, Jiří - Ostřížková, Lenka - Eid, Michal - Kovalčíková, Petra - Pavlík, Tomáš - Kala, Zdeněk
PY  - 2020
TI  - Correlation of survival length after pancreaticoduodenectomy for pancreatic head adenocarcinoma depending on tumor characteristics detected by means of computed tomography and resection margins status
JF  - Neoplasma
VL  - 67
IS  - 6
SP  - 1319-1328
EP  - 1319-1328
PB  - Slovenská akademie vied
SN  - 00282685
KW  - pancreatic cancer
KW  - pancreaticoduodenectomy
KW  - overall survival
KW  - resection margin
KW  - computed tomography
KW  - surgery
UR  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6781&category_id=85&option=com_virtuemart&vmcchk=1&Itemid=1
L2  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6781&category_id=85&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - Pancreatic carcinoma is an aggressive tumor with a grim prognosis. Accurate staging is essential for indicating surgery in patients with borderline resectable tumors. This paper examines the correlation between pre-operation characteristics of tumors found on CT, infiltration of individual resection margins as confirmed by a pathologist, and the survival of patients with resectable pancreatic head ductal adenocarcinoma. This prospective cohort study involved patients operated on for pancreatic head adenocarcinoma, which was clearly resectable based on the staging CT and intraoperative observation between 2011-2014. Only patients without postoperative complications who underwent adjuvant chemotherapy were analyzed. Seventy-nine patients were assessed, of which 16 (20.3%) had RO resection and 63 (79.7%) had R1 resection. Patients with R1 results had up to 2.7 times higher risk of death than patients with R0 resection. We found a trend towards shorter survival associated with a closer relationship of the tumor to the superior mesenteric vein/portal vein (SMV/PV) wall in the pre-operation CT examination. Patients with a tumor interface between the vein wall of up to 180 degrees circumference had up to 1.97 times higher risk of death than patients without (p=0.131). The results of our work confirmed that in our center, even surgically treated, clearly resectable pancreatic head tumors still have a high occurrence of positive surgical margins (R1 resection) and that tumors with R1 resection had statistically significantly reduced survival compared to R0 resection. A trend for shorter overall survival was found after tumor resection depending on the increasing interface between the tumor and the SMV/PV wall, but this result was not statistically significant.
ER  -

PROCHÁZKA, Vladimír, Jan HLAVSA, Lumír KUNOVSKÝ, Martina FARKAŠOVÁ, Martin POTRUSIL, Tomáš ANDRAŠINA, Alexandra LITAVCOVÁ, Jan MAZANEC, Jiří DOLINA, Lenka OSTŘÍŽKOVÁ, Michal EID, Petra KOVALČÍKOVÁ, Tomáš PAVLÍK a Zdeněk KALA. Correlation of survival length after pancreaticoduodenectomy for pancreatic head adenocarcinoma depending on tumor characteristics detected by means of computed tomography and resection margins status. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2020, roč.~67, č.~6, s.~1319-1328. ISSN~0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo\_{}2020\_{}190923N955.

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