| REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL a Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. Scientific reports. London: Nature Publishing Group, 2020, roč. 10, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-67827-4. |
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@article{1721656,
author = {Remšík, Ján and Pícková, Markéta and Vacek, Ondřej and Fedr, Radek and Bino, Lucia and Hampl, Aleš and Souček, Karel},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-67827-4},
keywords = {Breast cancer; Cancer stem cells},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells},
url = {https://doi.org/10.1038/s41598-020-67827-4},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1721656
AU - Remšík, Ján - Pícková, Markéta - Vacek, Ondřej - Fedr, Radek - Bino, Lucia - Hampl, Aleš - Souček, Karel
PY - 2020
TI - TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
JF - Scientific reports
VL - 10
IS - 1
SP - 1-12
EP - 1-12
PB - Nature Publishing Group
SN - 20452322
KW - Breast cancer
KW - Cancer stem cells
UR - https://doi.org/10.1038/s41598-020-67827-4
L2 - https://doi.org/10.1038/s41598-020-67827-4
N2 - The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
ER -
REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL a Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. \textit{Scientific reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-67827-4.
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