TGF-beta regulates Sca-1 expression and plasticity of
pre-neoplastic mammary epithelial stem cells

J 2020

TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO et. al.

Základní údaje

Originální název

TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

Autoři

REMŠÍK, Ján (703 Slovensko, domácí), Markéta PÍCKOVÁ (203 Česká republika, domácí), Ondřej VACEK (203 Česká republika, domácí), Radek FEDR, Lucia BINO, Aleš HAMPL (203 Česká republika, domácí) a Karel SOUČEK (203 Česká republika, garant, domácí)

Vydání

Scientific reports, London, Nature Publishing Group, 2020, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.379

Kód RIV

RIV/00216224:14310/20:00117612

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/s41598-020-67827-4

UT WoS

000548564900110

Klíčová slova anglicky

Breast cancer; Cancer stem cells

Štítky

14110517, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 4. 2021 10:50, Mgr. Marie Šípková, DiS.

Anotace

V originále

The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.

Návaznosti

EF16_025/0007381, projekt VaV

Název: Preklinická progrese nových organických sloučenin s cílenou biologickou aktivitou

Citovat

REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL a Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. Scientific reports. London: Nature Publishing Group, 2020, roč. 10, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-67827-4.

@article{1721656,
   author = {Remšík, Ján and Pícková, Markéta and Vacek, Ondřej and Fedr, Radek and Bino, Lucia and Hampl, Aleš and Souček, Karel},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-67827-4},
   keywords = {Breast cancer; Cancer stem cells},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells},
   url = {https://doi.org/10.1038/s41598-020-67827-4},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1721656
AU  - Remšík, Ján - Pícková, Markéta - Vacek, Ondřej - Fedr, Radek - Bino, Lucia - Hampl, Aleš - Souček, Karel
PY  - 2020
TI  - TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
JF  - Scientific reports
VL  - 10
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Nature Publishing Group
SN  - 20452322
KW  - Breast cancer
KW  - Cancer stem cells
UR  - https://doi.org/10.1038/s41598-020-67827-4
L2  - https://doi.org/10.1038/s41598-020-67827-4
N2  - The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
ER  -

REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL a Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. \textit{Scientific reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-67827-4.

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