REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL a Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. Scientific reports. London: Nature Publishing Group, 2020, roč. 10, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-67827-4. |
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@article{1721656, author = {Remšík, Ján and Pícková, Markéta and Vacek, Ondřej and Fedr, Radek and Bino, Lucia and Hampl, Aleš and Souček, Karel}, article_location = {London}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s41598-020-67827-4}, keywords = {Breast cancer; Cancer stem cells}, language = {eng}, issn = {2045-2322}, journal = {Scientific reports}, title = {TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells}, url = {https://doi.org/10.1038/s41598-020-67827-4}, volume = {10}, year = {2020} }
TY - JOUR ID - 1721656 AU - Remšík, Ján - Pícková, Markéta - Vacek, Ondřej - Fedr, Radek - Bino, Lucia - Hampl, Aleš - Souček, Karel PY - 2020 TI - TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells JF - Scientific reports VL - 10 IS - 1 SP - 1-12 EP - 1-12 PB - Nature Publishing Group SN - 20452322 KW - Breast cancer KW - Cancer stem cells UR - https://doi.org/10.1038/s41598-020-67827-4 L2 - https://doi.org/10.1038/s41598-020-67827-4 N2 - The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells. ER -
REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL a Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. \textit{Scientific reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-67827-4.
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