Epigenetic clock as a correlate of anxiety

J 2020

Epigenetic clock as a correlate of anxiety

MAREČKOVÁ, Klára; Anna PAČÍNKOVÁ; Anja KLASNJA; Jean SHIN; Lenka ANDRÝSKOVÁ et al.

Základní údaje

Originální název

Epigenetic clock as a correlate of anxiety

Autoři

MAREČKOVÁ, Klára; Anna PAČÍNKOVÁ; Anja KLASNJA; Jean SHIN; Lenka ANDRÝSKOVÁ ; Kateřina STAŇO KOZUBÍK; Zdenka PAUSOVÁ; Milan BRÁZDIL a Tomáš PAUS

Vydání

NeuroImage, Oxford, Elsevier Science Ltd, 2020, 2213-1582

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20602 Medical laboratory technology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.881

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/20:00117615

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

DNA methylation age;Anxiety;Gray matter volume;Frontal lobe;Sex differences

Štítky

143180, CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 6. 2025 09:23, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder, as compared with controls. Since MDD is highly correlated with anxiety, we hypothesized that symptoms of anxiety, as well as lower volume of grey matter (GM) in depression-related cortical regions, will be associated with faster epigenetic clock in a community-based sample of young adults. Participants included 88 young adults (53% men; 23–24 years of age) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) who participated in its neuroimaging follow-up and provided saliva samples for epigenetic analysis. Epigenetic age was calculated according to Horvath (Horvath, 2013). Women had slower epigenetic clock than men (Cohen’s d = 0.48). In women (but not men), slower epigenetic clock was associated with less symptoms of anxiety. In the brain, women (but not men) with slower epigenetic clock had greater GM volume in the cerebral cortex (brain size-corrected; R2 = 0.07). Lobe-specific analyses showed that in women (but not men), slower epigenetic clock was associated with greater GM volume in frontal lobe (R2 = 0.16), and that GM volume in frontal lobe mediated the relationship between the speed of epigenetic clock and anxiety trait (ab = 0.15, SE = 0.15, 95% CI [0.007; 0.369]). These findings were not replicated, however, in a community-based sample of adolescents (n = 129; 49% men; 12–19 years of age), possibly due to the different method of tissue collection (blood vs. saliva) or additional sources of variability in the cohort of adolescents (puberty stages, socioeconomic status, prenatal exposure to maternal smoking during pregnancy).

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NU20J-04-00022, projekt VaV

Název: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministerstvo zdravotnictví ČR, Zdravé stárnutí mozku: Celoživotní perspektiva, Podprogram 2 - juniorský - výzkumníci do 35 let

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

90121, velká výzkumná infrastruktura

Název: RECETOX RI

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Přiložené soubory

1721699.pdf

Citovat

MAREČKOVÁ, Klára; Anna PAČÍNKOVÁ; Anja KLASNJA; Jean SHIN; Lenka ANDRÝSKOVÁ; Kateřina STAŇO KOZUBÍK; Zdenka PAUSOVÁ; Milan BRÁZDIL a Tomáš PAUS. Epigenetic clock as a correlate of anxiety. NeuroImage. Oxford: Elsevier Science Ltd, 2020, roč. 28, č. 2020, s. 102458-102465. ISSN 2213-1582. Dostupné z: https://doi.org/10.1016/j.nicl.2020.102458.

@article{1721699,
   author = {Marečková, Klára and Pačínková, Anna and Klasnja, Anja and Shin, Jean and Andrýsková, Lenka and Staňo Kozubík, Kateřina and Pausová, Zdenka and Brázdil, Milan and Paus, Tomáš},
   article_location = {Oxford},
   article_number = {2020},
   doi = {https://doi.org/10.1016/j.nicl.2020.102458},
   keywords = {DNA methylation age;Anxiety;Gray matter volume;Frontal lobe;Sex differences},
   language = {eng},
   issn = {2213-1582},
   journal = {NeuroImage},
   note = {CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.},
   title = {Epigenetic clock as a correlate of anxiety},
   url = {https://www.sciencedirect.com/science/article/pii/S2213158220302953},
   volume = {28},
   year = {2020}
}

TY  - JOUR
ID  - 1721699
AU  - Marečková, Klára - Pačínková, Anna - Klasnja, Anja - Shin, Jean - Andrýsková, Lenka - Staňo Kozubík, Kateřina - Pausová, Zdenka - Brázdil, Milan - Paus, Tomáš
PY  - 2020
TI  - Epigenetic clock as a correlate of anxiety
JF  - NeuroImage
VL  - 28
IS  - 2020
SP  - 102458
EP  - 102458
PB  - Elsevier Science Ltd
SN  - 22131582
N1  - CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.
KW  - DNA methylation age;Anxiety;Gray matter volume;Frontal lobe;Sex differences
UR  - https://www.sciencedirect.com/science/article/pii/S2213158220302953
L2  - https://www.sciencedirect.com/science/article/pii/S2213158220302953
N2  - DNA methylation changes consistently throughout life and age-dependent alterations in DNA methylation can be used to estimate one’s epigenetic age. Post-mortem studies revealed higher epigenetic age in brains of patients with major depressive disorder, as compared with controls. Since MDD is highly correlated with anxiety, we hypothesized that symptoms of anxiety, as well as lower volume of grey matter (GM) in depression-related cortical regions, will be associated with faster epigenetic clock in a community-based sample of young adults. Participants included 88 young adults (53% men; 23–24 years of age) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) who participated in its neuroimaging follow-up and provided saliva samples for epigenetic analysis. Epigenetic age was calculated according to Horvath (Horvath, 2013). Women had slower epigenetic clock than men (Cohen’s d = 0.48). In women (but not men), slower epigenetic clock was associated with less symptoms of anxiety. In the brain, women (but not men) with slower epigenetic clock had greater GM volume in the cerebral cortex (brain size-corrected; R2 = 0.07). Lobe-specific analyses showed that in women (but not men), slower epigenetic clock was associated with greater GM volume in frontal lobe (R2 = 0.16), and that GM volume in frontal lobe mediated the relationship between the speed of epigenetic clock and anxiety trait (ab = 0.15, SE = 0.15, 95% CI [0.007; 0.369]). These findings were not replicated, however, in a community-based sample of adolescents (n = 129; 49% men; 12–19 years of age), possibly due to the different method of tissue collection (blood vs. saliva) or additional sources of variability in the cohort of adolescents (puberty stages, socioeconomic status, prenatal exposure to maternal smoking during pregnancy).
ER  -

MAREČKOVÁ, Klára; Anna PAČÍNKOVÁ; Anja KLASNJA; Jean SHIN; Lenka ANDRÝSKOVÁ; Kateřina STAŇO KOZUBÍK; Zdenka PAUSOVÁ; Milan BRÁZDIL a Tomáš PAUS. Epigenetic clock as a correlate of anxiety. \textit{NeuroImage}. Oxford: Elsevier Science Ltd, 2020, roč.~28, č.~2020, s.~102458-102465. ISSN~2213-1582. Dostupné z: https://doi.org/10.1016/j.nicl.2020.102458.

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