Offspring of women with gestational diabetes: a 5 year
follow-up

a 2020

Offspring of women with gestational diabetes: a 5 year follow-up

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Katarína CHALÁSOVÁ, Petr JANKŮ, Kateřina KAŇKOVÁ et. al.

Základní údaje

Originální název

Offspring of women with gestational diabetes: a 5 year follow-up

Autoři

BARTÁKOVÁ, Vendula (203 Česká republika, garant, domácí), Beáta BARÁTOVÁ (703 Slovensko, domácí), Katarína CHALÁSOVÁ (703 Slovensko, domácí), Petr JANKŮ (203 Česká republika) a Kateřina KAŇKOVÁ (203 Česká republika, domácí)

Vydání

56th EASD Annual Meeting of the European Association for the Study of Diabetes, 2020

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30202 Endocrinology and metabolism

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/20:00118638

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00125-020-05221-5

Klíčová slova česky

gestační diabetes; děti diabetických matek; prospektivní studie; psychomotorický vývoj

Klíčová slova anglicky

gestational diabetes; offspring of diagetic mothers; prospective study; psychomotor development

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 8. 2021 12:37, Mgr. Tereza Miškechová

Anotace

V originále

Background and aims: Gestational diabetes mellitus (GDM) represents a risk factor for both mother and her offspring in short-term (perinatal morbidity) as well as long-term horizon (postpartum diabetes or foetal programming). A lot of studies focused at peri/postnatal complications and selected parameters of GDM mother´s offspring, however relatively few were designed as prospective. No such study focused on this topic in Czech Republic so far. The aim of our study was to ascertain possible anthropometric and developmental abnormalities and/or morbidity in offspring of GDM mothers compare to controls in a 5-year follow-up. Materials and Methods: The prospective study comprised 89 offspring-mother pairs, of those 26 with GDM and 63 controls. Following offspring parameters were evaluated: weight, length/high, blood pressure, resting heart rate, psychomotor development, morbidity, need for regular drug therapy, need for regular specialist doctor observation, status of vaccination, duration of breastfeeding. Following perinatal data were available: offspring weight (macrosomia), length of delivery, necessity of delivery induction, necessity of instrument usage, necessity of Caesarean section, Apgar score, Base excess, cord blood PH. Results: At the age of 12 and 18 months, offspring of GDM mothers had significantly worse speech abilities (didn´t say any word at 12 months of age and didn´t link words in 18 months of age, P=0.015 and P=0.009 resp., Chi-square test). Psychomotor development and school readiness test was borderline worse in GDM group at 5 years of age (P=0.048 for both, Chi-square test). Offspring of GDM mothers were more ill in their first 5 years of age and need hospitalisation (P=0.022, Chi-square test). Adverse perinatal outcomes had no significant influence on offspring psychomotor development or morbidity up to 5 years in both groups. Offspring of obese mothers had significantly worse speech abilities in 18months of age (P=0.034, chi-square test), a higher percentile weight-for-high as in 3 years (P=NS), as in 5 years (P=0.04, Mann-Whitney test). Conclusion: This is unique prospective study focused on psychomotor development in a cohort of offspring of GDM mothers, comprised perinatal outcomes. Pilot results indicate certain differences in selected parameters in offspring of GDM mothers, especially in speech abilities and total morbidity. Moreover, were found a significant link of mother´s obesity and offspring adverse outcomes (increased adiposity and worse verbal language), however, validity is diminished by small number of obese respondents Acknowledgement: Study was supported by Ministry of Health of the Czech Republic, grant nr. NV18-01-00046

Návaznosti

NV18-01-00046, projekt VaV

Název: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministerstvo zdravotnictví ČR, Genetické skóre v predikci rizika diabetu a jeho komplikací

Citovat

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Katarína CHALÁSOVÁ, Petr JANKŮ a Kateřina KAŇKOVÁ. Offspring of women with gestational diabetes: a 5 year follow-up. In 56th EASD Annual Meeting of the European Association for the Study of Diabetes. 2020. Dostupné z: https://dx.doi.org/10.1007/s00125-020-05221-5.

@proceedings{1722142,
   author = {Bartáková, Vendula and Barátová, Beáta and Chalásová, Katarína and Janků, Petr and Kaňková, Kateřina},
   booktitle = {56th EASD Annual Meeting of the European Association for the Study of Diabetes},
   doi = {http://dx.doi.org/10.1007/s00125-020-05221-5},
   keywords = {gestational diabetes; offspring of diagetic mothers; prospective study; psychomotor development},
   language = {eng},
   title = {Offspring of women with gestational diabetes: a 5 year follow-up},
   url = {https://doi.org/10.1007/s00125-020-05221-5},
   year = {2020}
}

TY  - CONF
ID  - 1722142
AU  - Bartáková, Vendula - Barátová, Beáta - Chalásová, Katarína - Janků, Petr - Kaňková, Kateřina
PY  - 2020
TI  - Offspring of women with gestational diabetes: a 5 year follow-up
KW  - gestational diabetes
KW  - offspring of diagetic mothers
KW  - prospective study
KW  - psychomotor development
UR  - https://doi.org/10.1007/s00125-020-05221-5
N2  - Background and aims: Gestational diabetes mellitus (GDM) represents a risk factor for both mother and her offspring in short-term (perinatal morbidity) as well as long-term horizon (postpartum diabetes or foetal programming). A lot of studies focused at peri/postnatal complications and selected parameters of GDM mother´s offspring, however relatively few were designed as prospective. No such study focused on this topic in Czech Republic so far. The aim of our study was to ascertain possible anthropometric and developmental abnormalities and/or morbidity in offspring of GDM mothers compare to controls in a 5-year follow-up. Materials and Methods: The prospective study comprised 89 offspring-mother pairs, of those 26 with GDM and 63 controls. Following offspring parameters were evaluated: weight, length/high, blood pressure, resting heart rate, psychomotor development, morbidity, need for regular drug therapy, need for regular specialist doctor observation, status of vaccination, duration of breastfeeding. Following perinatal data were available: offspring weight (macrosomia), length of delivery, necessity of delivery induction, necessity of instrument usage, necessity of Caesarean section, Apgar score, Base excess, cord blood PH. Results: At the age of 12 and 18 months, offspring of GDM mothers had significantly worse speech abilities (didn´t say any word at 12 months of age and didn´t link words in 18 months of age, P=0.015 and P=0.009 resp., Chi-square test). Psychomotor development and school readiness test was borderline worse in GDM group at 5 years of age (P=0.048 for both, Chi-square test). Offspring of GDM mothers were more ill in their first 5 years of age and need hospitalisation (P=0.022, Chi-square test). Adverse perinatal outcomes had no significant influence on offspring psychomotor development or morbidity up to 5 years in both groups. Offspring of obese mothers had significantly worse speech abilities in 18months of age (P=0.034, chi-square test), a higher percentile weight-for-high as in 3 years (P=NS), as in 5 years (P=0.04, Mann-Whitney test). Conclusion: This is unique prospective study focused on psychomotor development in a cohort of offspring of GDM mothers, comprised perinatal outcomes. Pilot results indicate certain differences in selected parameters in offspring of GDM mothers, especially in speech abilities and total morbidity. Moreover, were found a significant link of mother´s obesity and offspring adverse outcomes (increased adiposity and worse verbal language), however, validity is diminished by small number of obese respondents Acknowledgement: Study was supported by Ministry of Health of the Czech Republic, grant nr. NV18-01-00046
ER  -

BARTÁKOVÁ, Vendula, Beáta BARÁTOVÁ, Katarína CHALÁSOVÁ, Petr JANKŮ a Kateřina KAŇKOVÁ. Offspring of women with gestational diabetes: a 5 year follow-up. In \textit{56th EASD Annual Meeting of the European Association for the Study of Diabetes}. 2020. Dostupné z: https://dx.doi.org/10.1007/s00125-020-05221-5.

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