The prospective Hemophilia Inhibitor PUP Study reveals distinct
antibody signatures prior to FVIII inhibitor development

J 2020

The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development

REIPERT, B. M., B. GANGADHARAN, C. J. HOFBAUER, V. BERG, H. SCHWEIGER et. al.

Základní údaje

Originální název

The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development

Autoři

REIPERT, B. M., B. GANGADHARAN, C. J. HOFBAUER, V. BERG, H. SCHWEIGER, J. BOWEN, Jan BLATNÝ (203 Česká republika, domácí), K. FIJNVANDRAAT, E. S. MULLINS, J. KLINTMAN, C. MALE, C. MCGUINN, S. L. MEEKS, V. C. RADULESCU, M. V. RAGNI, M. RECHT, A. D. SHAPIRO, J. M. STABER, H. M. YAISH, E. SANTAGOSTINO a D. L. BROWN

Vydání

BLOOD ADVANCES, WASHINGTON, AMER SOC HEMATOLOGY, 2020, 2473-9529

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Slovinsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.686

Kód RIV

RIV/00216224:14110/20:00117703

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1182/bloodadvances.2020002731

UT WoS

000593144300022

Klíčová slova anglicky

Hemophilia Inhibitor PUP; FVIII inhibitor development

Štítky

14110321, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 1. 2021 12:31, Mgr. Tereza Miškechová

Anotace

V originále

Preventing factor VIII (FVIII) inhibitors following replacement therapies with FVIII products in patients with hemophilia A remains an unmet medical need. Better understanding of the early events of evolving FVIII inhibitors is essential for risk identification and the design of novel strategies to prevent inhibitor development. The Hemophilia Inhibitor Previously Untreated Patients (PUPs) Study (HIPS; www. clinicaltrials.gov #NCT01652027) is the first prospective cohort study to evaluate comprehensive changes in the immune system during the first 50 exposure days ( EDs) to FVIII in patients with severe hemophilia A. HIPS participants were enrolled prior to their first exposure to FVIII or blood products ("true PUPs") and were evaluated for different immunological and clinical parameters at specified time points during their first 50 EDs to a single source of recombinant FVIII. Longitudinal antibody data resulting from this study indicate that there are 4 subgroups of patients expressing distinct signatures of FVIII- binding antibodies. Subgroup 1 did not develop any detectable FVIII-binding immunoglobulin G (IgG) antibodies. Subgroup 2 developed nonneutralizing, FVIII-binding IgG1 antibodies, but other FVIII-binding IgG subclasses were not observed. Subgroup 3 developed transient FVIII inhibitors associated with FVIII-binding IgG1 antibodies, similar to subgroup 2. Subgroup 4 developed persistent FVIII inhibitors associated with an initial development of high-affinity, FVIII-binding IgG1 antibodies, followed by IgG3 and IgG4 antibodies. Appearance of FVIII-binding IgG3 was always associated with persistent FVIII inhibitors and the subsequent development of FVIII-binding IgG4. Some of the antibody signatures identified in HIPS could serve as candidates for early biomarkers of FVIII inhibitor development.

Citovat

REIPERT, B. M., B. GANGADHARAN, C. J. HOFBAUER, V. BERG, H. SCHWEIGER, J. BOWEN, Jan BLATNÝ, K. FIJNVANDRAAT, E. S. MULLINS, J. KLINTMAN, C. MALE, C. MCGUINN, S. L. MEEKS, V. C. RADULESCU, M. V. RAGNI, M. RECHT, A. D. SHAPIRO, J. M. STABER, H. M. YAISH, E. SANTAGOSTINO a D. L. BROWN. The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development. BLOOD ADVANCES. WASHINGTON: AMER SOC HEMATOLOGY, 2020, roč. 4, č. 22, s. 5785-5796. ISSN 2473-9529. Dostupné z: https://dx.doi.org/10.1182/bloodadvances.2020002731.

@article{1726136,
   author = {Reipert, B. M. and Gangadharan, B. and Hofbauer, C. J. and Berg, V. and Schweiger, H. and Bowen, J. and Blatný, Jan and Fijnvandraat, K. and Mullins, E. S. and Klintman, J. and Male, C. and McGuinn, C. and Meeks, S. L. and Radulescu, V. C. and Ragni, M. V. and Recht, M. and Shapiro, A. D. and Staber, J. M. and Yaish, H. M. and Santagostino, E. and Brown, D. L.},
   article_location = {WASHINGTON},
   article_number = {22},
   doi = {http://dx.doi.org/10.1182/bloodadvances.2020002731},
   keywords = {Hemophilia Inhibitor PUP; FVIII inhibitor development},
   language = {eng},
   issn = {2473-9529},
   journal = {BLOOD ADVANCES},
   title = {The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development},
   url = {https://watermark.silverchair.com/advancesadv2020002731.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAABA4wggQKBgkqhkiG9w0BBwagggP7MIID9wIBADCCA_AGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM4i795NteaBYi_4jtAgEQgIIDwbi72fPiY61518P6v9IR00njkDl3nDKG},
   volume = {4},
   year = {2020}
}

TY  - JOUR
ID  - 1726136
AU  - Reipert, B. M. - Gangadharan, B. - Hofbauer, C. J. - Berg, V. - Schweiger, H. - Bowen, J. - Blatný, Jan - Fijnvandraat, K. - Mullins, E. S. - Klintman, J. - Male, C. - McGuinn, C. - Meeks, S. L. - Radulescu, V. C. - Ragni, M. V. - Recht, M. - Shapiro, A. D. - Staber, J. M. - Yaish, H. M. - Santagostino, E. - Brown, D. L.
PY  - 2020
TI  - The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development
JF  - BLOOD ADVANCES
VL  - 4
IS  - 22
SP  - 5785-5796
EP  - 5785-5796
PB  - AMER SOC HEMATOLOGY
SN  - 24739529
KW  - Hemophilia Inhibitor PUP
KW  - FVIII inhibitor development
UR  - https://watermark.silverchair.com/advancesadv2020002731.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAABA4wggQKBgkqhkiG9w0BBwagggP7MIID9wIBADCCA_AGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM4i795NteaBYi_4jtAgEQgIIDwbi72fPiY61518P6v9IR00njkDl3nDKG
L2  - https://watermark.silverchair.com/advancesadv2020002731.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAABA4wggQKBgkqhkiG9w0BBwagggP7MIID9wIBADCCA_AGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM4i795NteaBYi_4jtAgEQgIIDwbi72fPiY61518P6v9IR00njkDl3nDKG
N2  - Preventing factor VIII (FVIII) inhibitors following replacement therapies with FVIII products in patients with hemophilia A remains an unmet medical need. Better understanding of the early events of evolving FVIII inhibitors is essential for risk identification and the design of novel strategies to prevent inhibitor development. The Hemophilia Inhibitor Previously Untreated Patients (PUPs) Study (HIPS; www. clinicaltrials.gov #NCT01652027) is the first prospective cohort study to evaluate comprehensive changes in the immune system during the first 50 exposure days ( EDs) to FVIII in patients with severe hemophilia A. HIPS participants were enrolled prior to their first exposure to FVIII or blood products ("true PUPs") and were evaluated for different immunological and clinical parameters at specified time points during their first 50 EDs to a single source of recombinant FVIII. Longitudinal antibody data resulting from this study indicate that there are 4 subgroups of patients expressing distinct signatures of FVIII- binding antibodies. Subgroup 1 did not develop any detectable FVIII-binding immunoglobulin G (IgG) antibodies. Subgroup 2 developed nonneutralizing, FVIII-binding IgG1 antibodies, but other FVIII-binding IgG subclasses were not observed. Subgroup 3 developed transient FVIII inhibitors associated with FVIII-binding IgG1 antibodies, similar to subgroup 2. Subgroup 4 developed persistent FVIII inhibitors associated with an initial development of high-affinity, FVIII-binding IgG1 antibodies, followed by IgG3 and IgG4 antibodies. Appearance of FVIII-binding IgG3 was always associated with persistent FVIII inhibitors and the subsequent development of FVIII-binding IgG4. Some of the antibody signatures identified in HIPS could serve as candidates for early biomarkers of FVIII inhibitor development.
ER  -

REIPERT, B. M., B. GANGADHARAN, C. J. HOFBAUER, V. BERG, H. SCHWEIGER, J. BOWEN, Jan BLATNÝ, K. FIJNVANDRAAT, E. S. MULLINS, J. KLINTMAN, C. MALE, C. MCGUINN, S. L. MEEKS, V. C. RADULESCU, M. V. RAGNI, M. RECHT, A. D. SHAPIRO, J. M. STABER, H. M. YAISH, E. SANTAGOSTINO a D. L. BROWN. The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development. \textit{BLOOD ADVANCES}. WASHINGTON: AMER SOC HEMATOLOGY, 2020, roč.~4, č.~22, s.~5785-5796. ISSN~2473-9529. Dostupné z: https://dx.doi.org/10.1182/bloodadvances.2020002731.

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