| BALCAR, Vladimír Josef, Tomáš ZEMAN, Vladimír JANOUT, Jana JANOUTOVÁ, Jan LOCHMAN a Omar ŠERÝ. Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer's Disease in a Central European Population. Neurochemical Research. New Yorku: Springer Science+Business Media, Inc., 2021, roč. 46, č. 2, s. 411-422. ISSN 0364-3190. Dostupné z: https://dx.doi.org/10.1007/s11064-020-03176-y. |
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@article{1726356,
author = {Balcar, Vladimír Josef and Zeman, Tomáš and Janout, Vladimír and Janoutová, Jana and Lochman, Jan and Šerý, Omar},
article_location = {New Yorku},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s11064-020-03176-y},
keywords = {Clusterin; Late-onset Alzheimer’ s disease; Mild cognitive impairment; Single nucleotide polymorphism; Neurodegeneration; Neuroprotection; Genetic risk},
language = {eng},
issn = {0364-3190},
journal = {Neurochemical Research},
title = {Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer's Disease in a Central European Population},
url = {https://doi.org/10.1007/s11064-020-03176-y},
volume = {46},
year = {2021}
}
TY - JOUR
ID - 1726356
AU - Balcar, Vladimír Josef - Zeman, Tomáš - Janout, Vladimír - Janoutová, Jana - Lochman, Jan - Šerý, Omar
PY - 2021
TI - Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer's Disease in a Central European Population
JF - Neurochemical Research
VL - 46
IS - 2
SP - 411-422
EP - 411-422
PB - Springer Science+Business Media, Inc.
SN - 03643190
KW - Clusterin
KW - Late-onset Alzheimer’ s disease
KW - Mild cognitive impairment
KW - Single nucleotide polymorphism
KW - Neurodegeneration
KW - Neuroprotection
KW - Genetic risk
UR - https://doi.org/10.1007/s11064-020-03176-y
L2 - https://doi.org/10.1007/s11064-020-03176-y
N2 - Clusterin (CLU; also known as apolipoprotein J, ApoJ) is a protein of inconstant structure known to be involved in diverse processes inside and outside of brain cells. CLU can act as a protein chaperon or protein solubilizer, lipid transporter as well as redox sensor and be anti- or proapoptotic, depending on context. Primary structure of CLU is encoded by CLU gene which contains single nucleotide polymorphisms (SNP's) associated with the risk of late-onset Alzheimer's disease (LOAD). Studying a sample of Czech population and using the case-control association approach we identified C allele of the SNP rs11136000 as conferring a reduced risk of LOAD, more so in females than in males. Additionally, data from two smaller subsets of the population sample suggested a possible association of rs11136000 with diabetes mellitus. In a parallel study, we found no association between rs11136000 and mild cognitive impairment (MCI). Our findings on rs11136000 and LOAD contradict those of some previous studies done elsewhere. We discuss the multiple roles of CLU in a broad range of molecular mechanisms that may contribute to the variability of genetic studies of CLU in various ethnic groups. The above discordance notwithstanding, our conclusions support the association of rs1113600 with the risk of LOAD.
ER -
BALCAR, Vladimír Josef, Tomáš ZEMAN, Vladimír JANOUT, Jana JANOUTOVÁ, Jan LOCHMAN a Omar ŠERÝ. Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer's Disease in a Central European Population. \textit{Neurochemical Research}. New Yorku: Springer Science+Business Media, Inc., 2021, roč.~46, č.~2, s.~411-422. ISSN~0364-3190. Dostupné z: https://dx.doi.org/10.1007/s11064-020-03176-y.
|
