PAZOUREK, Jiří and Klára LAMAČKOVÁ. Determination of Lactulose/Mannitol Ratio by HPLC for Assessment of Gut Permeability. In Horna, A. 18th International Nutrition & Diagnostics Conference, INDC 2018, Prague, Czech Republic. Prague: RADANAL, 2018.
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Basic information
Original name Determination of Lactulose/Mannitol Ratio by HPLC for Assessment of Gut Permeability
Authors PAZOUREK, Jiří and Klára LAMAČKOVÁ.
Edition Prague, 18th International Nutrition & Diagnostics Conference, INDC 2018, Prague, Czech Republic. 2018.
Publisher RADANAL
Other information
Original language English
Type of outcome Proceedings paper
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Pharmacy
Changed by Changed by: doc. RNDr. Bc. Jiří Pazourek, Ph.D., učo 2356. Changed: 15/5/2021 12:38.
Abstract
Lactulose-mannitol ratio (LMR) is the most commonly used test useful in diagnostics of many disorders of absorption in small intestine. An impaired intestinal epithelium can cause different, usually higher permeability for substances that would not cross the barrier under normal conditions. In the case of damaged intestinal wall the substances can be detected in blood or urine in higher concentrations. Urine sampling is a comfortable and non-invasive way to assess the gut permeability. The most reliable method of measurement of concentration of lactulose and mannitol in urine is HPLC.
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