Voltammetry of a Novel Antimycobacterial Agent
1-Hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide in a
Single Drop of a Solution

J 2018

Voltammetry of a Novel Antimycobacterial Agent 1-Hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide in a Single Drop of a Solution

GAJDAR, J, Tomáš GONĚC, J JAMPILEK, Marie BRÁZDOVÁ, Z BABKOVA et. al.

Basic information

Original name

Voltammetry of a Novel Antimycobacterial Agent 1-Hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide in a Single Drop of a Solution

Authors

GAJDAR, J, Tomáš GONĚC, J JAMPILEK, Marie BRÁZDOVÁ, Z BABKOVA, Miroslav FOJTA, J BAREK and J FISCHER

Edition

Electroanalysis, WEINHEIM, WILEY-VCH Verlag GmbH, 2018, 1040-0397

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.691

DOI

http://dx.doi.org/10.1002/elan.201700547

UT WoS

000419697700007

Keywords in English

Hydroxynaphthalene-2-carboxanilide; Microcell; Single drop analysis; Voltammetry

Abstract

V originále

The aim of this study is the development of a miniaturized voltammetric method for the determination of an antimycobacterial agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20L) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH7.0 and dimethyl sulfoxide (9:1, v/v). HNN gave one cathodic peak at around -0.6V and one anodic peak at around +0.2V vs. Ag|AgCl (3molL(-1) KCl) reference electrode. Determination of HNN in a 10mL volume gave the limit of quantification around 10nmolL(-1) by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20L) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.

Citovat

GAJDAR, J, Tomáš GONĚC, J JAMPILEK, Marie BRÁZDOVÁ, Z BABKOVA, Miroslav FOJTA, J BAREK and J FISCHER. Voltammetry of a Novel Antimycobacterial Agent 1-Hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide in a Single Drop of a Solution. Electroanalysis. WEINHEIM: WILEY-VCH Verlag GmbH, 2018, vol. 30, No 1, p. 38-47. ISSN 1040-0397. Available from: https://dx.doi.org/10.1002/elan.201700547.

@article{1726877,
   author = {Gajdar, J and Goněc, Tomáš and Jampilek, J and Brázdová, Marie and Babkova, Z and Fojta, Miroslav and Barek, J and Fischer, J},
   article_location = {WEINHEIM},
   article_number = {1},
   doi = {http://dx.doi.org/10.1002/elan.201700547},
   keywords = {Hydroxynaphthalene-2-carboxanilide; Microcell; Single drop analysis; Voltammetry},
   language = {eng},
   issn = {1040-0397},
   journal = {Electroanalysis},
   title = {Voltammetry of a Novel Antimycobacterial Agent 1-Hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide in a Single Drop of a Solution},
   volume = {30},
   year = {2018}
}

TY  - JOUR
ID  - 1726877
AU  - Gajdar, J - Goněc, Tomáš - Jampilek, J - Brázdová, Marie - Babkova, Z - Fojta, Miroslav - Barek, J - Fischer, J
PY  - 2018
TI  - Voltammetry of a Novel Antimycobacterial Agent 1-Hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide in a Single Drop of a Solution
JF  - Electroanalysis
VL  - 30
IS  - 1
SP  - 38-47
EP  - 38-47
PB  - WILEY-VCH Verlag GmbH
SN  - 10400397
KW  - Hydroxynaphthalene-2-carboxanilide
KW  - Microcell
KW  - Single drop analysis
KW  - Voltammetry
N2  - The aim of this study is the development of a miniaturized voltammetric method for the determination of an antimycobacterial agent 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (HNN) in a single drop (20L) of a solution by cathodic and anodic voltammetry at a glassy carbon electrode. Cyclic voltammetry was used to investigate its redox properties followed by the optimization of differential pulse voltammetric determination in a regular 10mL volume. The optimal medium for the analytical application of both cathodic and anodic voltammetry was found to be Britton-Robinson buffer pH7.0 and dimethyl sulfoxide (9:1, v/v). HNN gave one cathodic peak at around -0.6V and one anodic peak at around +0.2V vs. Ag|AgCl (3molL(-1) KCl) reference electrode. Determination of HNN in a 10mL volume gave the limit of quantification around 10nmolL(-1) by both adsorptive stripping anodic and cathodic voltammetry. Afterwards, miniaturized voltammetric methods in a single drop of solution (20L) were investigated. This approach requested some modifications of the cell design and voltammetric procedures. A novel method of removing dissolved oxygen in a single drop had to be developed and tested. Developed miniaturized voltammetric methods gave parameters comparable to the determination of HNN in 10mL. The applicability of the miniaturized method was verified by the determination of HNN in a drop of a bacterial growth medium.
ER  -

GAJDAR, J, Tomáš GONĚC, J JAMPILEK, Marie BRÁZDOVÁ, Z BABKOVA, Miroslav FOJTA, J BAREK and J FISCHER. Voltammetry of a Novel Antimycobacterial Agent 1-Hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide in a Single Drop of a Solution. \textit{Electroanalysis}. WEINHEIM: WILEY-VCH Verlag GmbH, 2018, vol.~30, No~1, p.~38-47. ISSN~1040-0397. Available from: https://dx.doi.org/10.1002/elan.201700547.

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